Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Further impact factors for apoptosis and NF-kB.

(NOTE: This is NOT a main index home page. ).

Wnt pathway and related
 
Family Name specices apoptosis NF-kB KO structure 3D locus upstream regulators binding  factors memos
WNT Wnt1 human inhibit induce
Wnt
12q12-q13 PEA3, NF-kB, CD9
targets

Wnt2 human


Wnt
7q31



Wnt2b, Wnt13 human


Wnt
1p13 Nef, CD9



Wnt3 human


Wnt
17q21



Wnt3a, Wnt14 human related?
L Wnt
1q42 RA
targets

Wnt4 human


Wnt
1p36.23-p35.1 A2aR, Pg



Wnt5a human


Wnt
3p21-p14 estrogen, LPS, UVB, CD9, IL13



Wnt5b human


Wnt
12p13.3 Subst.P


Wnt6 human


Wnt
2q35



Wnt7a human


Wnt
3p25 TNFa, TTF-1, GATA6, Foxa2, Subst.P, estrogen


Wnt7b human


Wnt
22q13 TNFa, ARNT2



Wnt8a human




5q31



Wnt8b human


Wnt
10q24



Wnt10a human


Wnt
2q35 Subst.P


Wnt10b human


Wnt
12q13



Wnt11 human


Wnt
11q13.5



Wnt15, Wnt9b human


Wnt
17q21  



Wnt16 human


Wnt
7q31


Dickkopf DKK-1(Dickkopf-1) human enhance

DKK
10q11.2 Bmp4, EWS/FLI-1, p53, UV, c-Jun, Ye
LRP5, LRP6, Kremen1, Kremen2 anti-Wnt

DKK-2 human


DKK
4q25 CREB LRP5, LRP6

DKK-3 human


DKK
11p15.3 EWS/FLI-1


DKK-4 human


DKK
8p11.2-11.1


LRP LRP5 human

1 (LDLRbx5/EGF)x4/LDLRax3/TM
11q13.4



LRP6 human

1 (LDLRbx5/EGF)x4/LDLRax3/TM
12p11-p13
DKK1,DKK2
Kremen Kremen1 human


kringle/WSC/CUB/TM
22q12.1
DKK

Kremen2 human


kringle/WSC/CUB/TM
16p13.3
DKK
Frizzled Fzd1 human
induce


Fz/7TM
7q21 estrogen
anti-Wnt

Fzd2 human
induce


Fz/7TM
17q21.1 Hoxc8, Wnt-1, RA


Fzd3 human


Fz/7TM 1 8p21



Fzd4 human


Fz/7TM
11q14-q21 PTH


Fzd5 human


Fz/7TM
2q33-q34



Fzd6 human


Fz/7TM
8q22.3-q23.1



Fzd7 human


Fz/7TM
2q33 IL10, Stat4b, b-catenin



Fzd8 human


Fz/7TM 1 10p11.21 AdV


Fzd9 human


Fz/7TM
7q11.23 Subst.P, LPS


Fzdz10 human


Fz/7TM
12q24.33



SARP1, SFRP2 human, mouse protect

Fz/NTR
4q31.3 estrogen


SARP2, FRP, SFRP1 human sensitize

Fz/NTR
8p12-p11.1 DAC/TSA, PRX2



SFRP3, FRP3, FRZB human, mouse related?

Fz/NTR
2qter PRX2


SARP3/SFRP5 human related?

Fz/NTR
10q24.1



SFRP4/frpHE human


Fz/NTR
7p14.1



MFRP human


TM/CUB/LDLa/CUB/LDLa/Fz
11q23



carboxypepdase Z, CPZ human


Fz/carboxypeptidase
4p16.1


armadillo APC human, mouse, rat, Xenopus, D.m., Urechis, C.e.(K04G2.8)
inhibit

L cc/cc/Ser-rich/DE-rich 
armadillox8/SAMP rpt
L 5q21-q22 c-Myc, p53, USF1, USF2
casp

APC2, APCL human, Dm




19p13.3



beta-catenin human, mouse, rat, Xenopus, sea urchin,
inhibit?

1 armadillox12 L 3p21 NF-IL6, TGFb, FSH
APC, a-cat., Tcf, Lef casp,in bcl-2 KO, targets

gamma-catenin, junction plakoglobin, JUP human


armadillox11 1 17q21



delta2-catenin human


cc/armadillox9
5p15.2
Erbin

ARVCF human


cc/armadillox7
22q11
Erbin

plakophilin human




2q23-q31



armadillo D.m., house fly, spoonworm








RGS axin 1 human, mouse, rat, chicken
induce


RGS/cc/GSKBD-bBD/dishevelled L 16p13.3 E2F1 PIASs SUMO

axin 2/axil,/conductin human, mouse, rat


RGS/cc/DAX/dishevelled
17q23-q24 TNFa, TCF, b-cat, estrogen


RGS1, IER1
human, mouse


RGS
1q31 IL2, PMA


RGS2 human, mouse


RGS L 1q31 AIRE, TNFa, PTH, CRF, LPS, Lm, YopP, A2aR, Blimp1 Galpha accelerate GTPase/inhibit signaling

RGS3 human, mouse induce(T)

PDZ/PH/RGS
9q31-q33 IL1, TNFa, IL13



RGS4 human, mouse, rat inhibit
1
RGS L 1q23.1 AP1, Brn3a, HCV
inhibit MAPKs

RGS5 human, mouse


RGS
1q23.1 PDGF, VEGF, IL1



RGS6 human, mouse


DEP/GGL/RGS
14q24.3



RGS7 human, mouse


DEP/GGL/RGS
1q43



RGS8 human, mouse, rat


RGS
1q25



RGS9 human, mouse

1 GGL/RGS L 17q23-q24



RGS10 human, mouse


GGL
10q25 Brn3a, ARNT2


RGS11 human


DEP/GGL/RGS
16p13.3



RGS12 human


PDZ/PTB/RGS/RBDx2/GoLoco
4p16.3 Cdx2



RGS13 human, mouse


RGS
1q25.3



RGS14
human





5q35.3
TNFa


RGS16 human


RGS
1q25-q31 NF-kB, TNFa, IKKs, LPS, IL10



RGS17 human


RGS
6q25-q26



RGS18 human


RGS
1q31.2



RGS19, GAIP human


RGS
20q13.3



RGS20, RGSZ1 human


RGS
8q12.1



other RGS F16H9.1(C.e.) etc






Dishevelled
NKD naked cuticle, NKD1  human, Dm


EF
16q12 Wingless

Dishevelled Dishevelled 1, DVL1 human, rat,Dm., Xl, Ce (yk10b11.5, yk35a4.5, yk134c11.5, T05C12.6)
induce


N domain/DHR L 1p36 Ld MusK, Nkd, mtSOD1, NEDL1 Ub

Dishevelled 2, DVL2 human, mouse, Xl,



1 17p13.2



Dishevelled 3, DVL3 human, mouse, zebrafish,




3q27


DAAM1 DAAM1 human


cc/FH2
14q22.3 FKHR


DAAM2 human


cc/FH2
6p21.1



diaphanous 1, DIAPH1 human


M/cc/FH2
5q31


GSK GSKbeta3 see kinases








LEF-TCF LEF-TCF see TFs








CCN WISP1 human
protect


IB/VWC/TSP1/CT
8q24.1-q24.3 CREB, Wnt1, b-catenin, CD9

binds to decorin, biglycan

WISP2 human


IB/VWC/TSP1
20q12-q13.1 Wnt1


WISP3 human


IB/VWC/TSP1/CT
6q22-q23 CD9


CTGF human


IB/VWC/TSP1/CT
6q23.1 SCF, TGFb, TNFaCSBG, IL1, BMPs, FKHR, AktDIM, WT1, Egr1, Lm, Pg Ye
,
MVA



NOV human


IB/VWC/TSP1/CT
8q24.1


Review of Wnt signaling by Polakis (Genes Dev. 2000), Peifer & Polakis (Science 2000), van de Wetering et al. (Cell 2002)

Microarray of  APC by Lin et al. (Cancer Res. 2001)
Microarray of  RA & Wnt-1 by Tice et al. (J. Biol. Chem. 2002)



 
 

SMAD
 
Protein Species apoptosis NF-kB JNK locus binding partner KO upstream regulators 3D memo
SMAD1(MADR1,Xmad), MAD(Dm),Sma, MADH1 human,mouse, rat, X.laevis, MAD(D.m.,), C.e. (Sma2 in ZK370/pAR2, Sma3 in R13F6)


4q28 SMAD4, Tob, ERa, Smurf2
ALK1, ribavirin, TNFa
1 BMP.
SMAD2 (MADR2, MAD2, JV18-1) human,mouse,rat,X.laevis stimulate

18q21.1 SMAD4, Hgs, p53, Ski L estrogen 1 TGFb/Activin
SMAD3 (MAD3, jv15-2) human, mouse, rat enhance

15q21-q22 SMAD4, Ski, GATA3, YB1Akt, PIASy L ARNT2, hypoxia, UV, Ye L TGFb/Activin
SMAD4 (Dpc4, Medea) human,mouse,rat, Medea (D.m.), Sma4 in R12B2, DAF-3 (C.e.) in F25E2 induce

18q21.1 Ski,SMIF, Dok1, PIASy L FKHR, Smad2; DAXX

Sumo, Ub
SMAD5 human, mouse, rat (inhibit)/mediate

5q31 Tob L IL1, TEL, phencyclidine, Hp(cagPAI)
angiogenesis, BMP
SMAD6 human, mouse,X.laevis(truncated) inhibit

15q21-q22

ALK1, Egr1, BMPs, TGFb, Pg

antagonize 
TGFb/Activin/BMP
SMAD7 human,mouse,X.laevis induce/inhibit inhibit induce 18q21.1 p38, PIASy, WWP1

p53, Smad3/4, Ski,TGFb, Sp1, AP1, endostatin, Sp, HHV8, ALK1, Gab2

antagonize 
TGFb/Activin/BMP
SMAD8 X.laevis







BMP
SMAD9 human


13q12-q14




DAD D.m.








F01G10.8,F37D6.7,R05D11,, C.elegans








SKI (human)




1q22-q24
SMAD3/4, HIPK2
L
; Cdc34
1

Sno (human)




3q26




TGFb
Review (non-online) by Heldin et al. (Nature 1997)
Review (non-online) by Derynck et al. (Cell 1998)
Review of Ski/Sno by Luo K (Curr Opin Genet Dev. 2004)

TGF beta family
 
Protein Species apoptosis NF-kB JNK KO Locus Upstream regulators Memo
TGFb1 human, mouse, Ce(Dbl1) induce/(inhibit) inhibit/(induce) induce L 19q13.2 EGR1, AP1, WT1, c-Myc, N-Myc, Sp1, RARa, RXRa, RA, VDR, EWS/FLI-1, TNFa, Fas, TRAIL, CD28/PMA, LPS, MDPb-glucan, Pg, Py, Sm, ECM, PTH, NGF, insulin, GM-CSF, UVB, EP4, D3, Ha-Ras,E1A,HBx, IE2, E6(HPV16), LMP1, tat, Nef, apoptotic cells, PTEN, PMA, AgII, EP4, DIM, I3C targets, inflammation. fibronectin,PDGF-B, IL2
TGFb2 human, mouse induce/inhibit


1q41 Rb, c-Myc, USFsAP1/ATF2, CREB, ATF1, PRX2, LPS, Hf, Ma, Sp, St, TSH, CSV-B3, LMP1, PAX3-FKHR, ER, GR, genistein, DIM, I3C
TGFb3 human,mouse induce/inhibit
induce L 14q24 Sp1, c-Myc, methylation, SCF, Stat4, Nur77, D3
2nd palate fusion, lung
GDF1 human, mouse


1 19p12

GDF2, BMP9 human



10q11.21

GDF3 human, mouse



12p13.1

GDF5/LAP4/CDMP1 human, mouse

(-) L 20q11.2
LPS binding
GDF6 mouse






GDF7 mouse






GDF8, myostatin human, mouse


L 2q32.2 Nef, CD28, VDR, Brn3b
GDF9 human, mouse
need?


L 5q31.1 GCNF ovarian folliculogenesis
GDF9B, BMP15 human



Xp11.2 GCNF
GDF10, BMP3B human, mouse



10q11.21 IFNs, IL1, H-Ras
GDF11, BMP11 human


1 12q13.13

Inhibin alpha human


L 2q33-q36 hypoxia, b-glucan
Activin/Inhibin beta A human, mouse
induce


1 7p15-p13 LPS, BLP, N-Myc, IGF1, TNFa, Sd, TPA, hypoxia, OX-CA
Activin/Inhibin beta B human, mouse


L 2cen-q13

Activin/Inhibin beta C human, mouse


1 12q13.1 BMP2
BMP1, TLD human


1 8p21 PMA, SCF, phenytoin
BMP2 human, mouse induce, inhibit

1 20p12 NF-kB, Egr1, TNFa, MDP, IKKs, RA, PMA, CBFA1, TGFb, VDR, estrogen, EV71 amnion/chorion, heart, targets
BMP3 human, mouse


1 4p14-q21 PTH
BMP4 human, mouse
induce


L 14q22-q23 COUP-TFI, USFs, CBFA1, AP1, c-Myc, Xiro1, p53, GATA6, Egr1, Pg, St. LPS, IL1, IGF1, RANTES, PTH, T3, VEGF, shear stress, H-Ras, RA induce Msx1,2
BMP5 human, mouse
induce


1 6p12.1 HOXD3
BMP6 human, mouse


1 6p24-p23 Fas, VEGF, camptothecin
BMP7 human, mouse
induce


L 20q13 RA, IL1a, PTH kidney & eye, targets
BMP8 human, mouse (8A, 8B)


A 1p35-p32 Pg
BMP10 human



2p13.2

EBAF, LEFTY/Stra3/TGFb4 human, mouse



1q42.1 Nef, CsA,
MIC1, PLAB, GDF15, NAG1, PDF,PTGFb human, mouse
inhibit



19p13.2-p13.1 YopP, HPV16, p53, p73, ALK1, PMA, AP1
MIS, MIF, AMH human, mouse
induce
induce
1 19p13.3-p13.2 SF-1, GATA4, Myc, SOX9, Ptx1, IGF1
, VLP

Ventroptin/Neuralin1/chordin-like human, mouse





antagonize BMP4
DVR-1, VG-1 Xenopus






Xnr-4 Xenopus






DPP-C D.m.






screw D.m.






60A D.m.,






Microarray & Proteomics analyses of

TGFbeta (by Verrecchia 2001)
On-line review of
TGFb by Derynck & Zhang (Nature 2003), by  Gorelik & Flavell (Nat Rev Immunol 2002)


TGFR family and TGF-associated proteins
 
group Protein Species KO locus 3D upstream regulators memo

ActR-I, SKR1, ALK2 human
2q23-q24
Ld, Subst.P

ActR-IB, SKR2, ALK4 human 1 12q13



ActR-IC, ALK7, ACVR1C
human

2q24.2


induce apoptosis

ActR-II human 1 2q22.2-q23.3



ActR-IIB human
3p22-p21.3
MTF1, HPV31, Ct, HHT

ALK1, SKR3 human 1 12q11-q14
ALK1 targets

TGFR-1, SKR4, ALK5 human 1 9q33-q34 1 Ma, insulin, cantharidin targets

TGFR-2 human L 3p22
Sp1, FLI1, c-Myc, TNFa, CD3/28, WT1, IGFBP2, PPARa, TIMP1

BMPR-IA, SKR5, ALK3 human 1
10q22.3
RA

BMPR-IB, ALK6 human L 4q23-q24

cumulus expansion

BMPR-II human
2q33
ALK1

AMHR human 1 12q13
Hp

TGFRbR III human 1 1p33-p32

This is TGFR family but ZP
CD105 endoglin, ENG, CD105 human L 9q33-q34.1
HCV TGFbR accessory 
LTBP LTBP1 human
2p12-q22

assembly/secretion of TGFb1

LTBP2 human
14q24
TNFa


LTBP3 human L 11q12
(EGF/TB)x2/EGFx14/TB/EGFx2/TB/EGFx2 Stat4

LTBP4 human
19q13.1-q13.2


STAT
 
protein Species apoptosis
upstream regulators KO 3D casp memo
STAT1 human, rat, mouse, Xl, zebrafish inhibit/mediate TRADD, Runx2 TRAIL, Fas, IFNa, IFNg, IFNb, IL1b/IFNg, IFNk, CIITA, PMA, CD3&IL2, ZBP89, LPS, PGN, Mt, Pg, Sp, CpG, HCV, IGFBP3, ALK1, ischaemia, PIAS1, Cbl, Bcl6, ER, Ets1, A2aR, TIMP1, ribavirin L
1  for IFNa,b,g, IL2,6,11,9,21,22,27,NNT
STAT2 human, mouse
IFNaR1 IFNa/b, UVA, LTA, Lm, TIMP1
1

for IFNa,b, IL28A, 28B, 29
STAT3 human, mouse, rat, zebrafish
inhibit
ILRs, PKCd, NF-kB, caveolin-1, GRIM19, Hsp90 IGF1, IL6, LPS, Bm, Ld, Lm, Mt, Tgirrad, Tyk2, MEKK1, TIMP1
L 1
IL2,6,7,9,10,11,21,22,27, IL28A, 28B,29,NNT, OSM,LIF, targets
STAT4 human, mouse, zebrafish

IL1, IL2, AgII, PMA, PGN, Ld, Mt, Tg, phenytoin, UVA L

IL12, 23,27, targets
STAT5 human (A, B), mouse (A, B), rat (A, B), pig(A, B), bovine(A,B), sheep(A), chicken, Xl, trout, zebrafish
inhibit
CBP, NMI, HDAC1, SMRT LPS, PMA,CsA/FK506TNFa, IL1b/TNFa, IL5, DEX,Cbl, ER, camptothecin, methotrexate, SCF; adenosine
L

IFNg, IL2,9,7,15,21,22,27, Epo, OSM,LIF
STAT6 human, mouse
NCoA-1, p100 SCF, c-Myc L

IL4,13
Other D.disc., C.e, ,D.m..






Review by Darnell  (Science 1997 )
Modulation of STAT signaling by STAT-interacting proteins. by Shuai K(Oncogene 2000)

Sara family
 
Protein Species binding partner apoptosis locus memo
Sara human, mouse, Xl, Dm Smad2
1p32.3 Sara-N/FYVE/SBD/Sara-C
Endofin, ZFYVE16 human, mouse

5p15.2-q14.3 KI-N/FYVE/Sara-C
Kap-1 C.elegans,AC004564.4(D.m.). A-kinase RI

Kap-N/FYVE/Sara-C

 

Microarray analysis of IFNa, b and g targets
Interferon Stimulated Gene Database

JAK
 
Protein Species KO apoptosis locus structure upstream regulators
JAK1 human, mouse,D.m. (HOPSCOTCH) 1
1p32.3-p31.3 ERMSH2/kinasex2 FKHRL1, IFNa, FSH, Pa, Yp, Mt, TCPTP, BRCA1, methamphetamine
JAK2 human, mouse L
inhibit/ mediate
9p24 ERM/SH2/kinasex2 CD3&IL2, ARNT2
JAK3/L-JAK human, mouse L
19p13.1 ERM/SH2/kinasex2 Tprim, LPSCSBG, Nef, TCPTP, PTH, androgen
Tyk2 human, mouse L
19p13.2 ERM/SH2/kinasex2 PTP1B, PAF
Review of JAK by Mathey-Prevot & Perrimon

For interferon, interferon receptor, see ILs.
 

SOCS moved to E3.
 
 
name Species apoptosis NF-kB memo
CGRP human, mouse enhance inhibit

CTGF family, ECM-associated
 
na,eas Species locus KO apoptosis NF-kB structure regulator memo
CTGF, Fisp12, Hcs24 human 6q23.1 1 induce/inhibit
IB/VWC/TSP1/CT WT1, TGFb, TNFa, TGFb1, TGFb2, bFGF, EGF, VEGF(-), Lm, Thrombin, Src, PKC, Akt, PI3K, Flt1, KDR
Nov human 8q24.1


IB/VWC/TSP1/CT

CyR61, IGFBP10 human 1p22.3
(inhibit)
IB/VWC/TSP1/CT PDGF, serum, TGFb, PMA, v-src angiogenesis
WISP1 human 8q24.1-q24.3


IB/VWC/TSP1/CT Wnt1, CREB
WISP2 human 20q12-q13


IB/VWC/TSP1/CT estrogen, serum
WISP3 human 6q22-q23


IB/VWC/TSP1/CT Wnt1



midkine/pleiotrophin
 
family name species KO
structure apoptosis locus regulator memo
Pleiotrophin midkine/NEGF2 human, mouse, X. laevis
Pro/R1/R2
inhibit
11p11.2 RARb2, androgen, TTF1, phenytoin nucleolin

pleiotrophin/NEGF1/HBGF8 human, mouse, zebrafish(1,2) L
Pro/R1/R2
regulate




miple1 fly (1)
Pro/R1/R2




miple2 fly (2)
Pro/proDDPCD/R1/R2
3L; 61A1



Plant
family name species memo
NEP1 NEP1 Fusarium oxysporum, Pythium aphanidermatum






Ligands of membrane-located receptor kinase
 
family name species structure apoptosis NF-kB locus KO TFs regulator memo
PDGF PDGFA human PDGF inhibit/ induce induce 7p22
WT1, Sp1, Egr1,Stat3, GCF2EGR1 NRF2KLF5, TGFb, IL1, RANKL, PMA, PKR, Erks, Nef, IL10/LPS, Hi, Ma, SCF, RA, ErbB4, D3 targets

PDGFB/SIS human PDGF  
22q12.3-q13.1
NF-kB, Elk-1, Smads, Sp1
AII, RA, TGFb, TRH, TNFa, IL1, Pg, Ma, PKCzeta, hypoxia p202, targets

PAP1, HASPP28, PDAP1 human PDGF

7q22.1-7q31.33

IGF1

VEGF human PDGF
inhibit
activate 6p12
Sp1 NF-kB, IL-1, IL6, bFGF, HGF, ET-1, CD3, LPS, CSBG, Ct, MtNc, HHV8, LMP1, TNFa, Fas, M-CSF, IFNa, Subst.P, IGF1, FSH, D3,Egr1, UVirrad, HIF1, hypoxia, NO, Nef, sIL6R, Rac2, hypoxia, camptothecin, genistein, CD9 targets

VEGF B human PDGF
inhibit

11q13 L Sp1 PDGF, PKC, PKCa, PKCzeta, PGE2, IL-1, GM-CSF, AII, IL-5PTH, hypoxia, Hp, E2F1, phenytoin, Blimp1

VRP, VEGF C human PDGF

4q34.1-q34.3

NF-kB, Stat4a, EWS/FLI-1, TNFa, IFNa, g, C5a, irrad, b-glucan, Ct, HHV8, HPV16, heregulin-beta1, TNFa, IL1b, p38, ribavirin

FIGF/VEGF D human PDGF

Xp22.31
c-fos


PGF human PDGF

14q24-q31
MTF-1 hypoxia, A2aR

SCDGF-B human CUB/PDGF

11q22




PDGF C, SCDGF, fallotein human CUB/PDGF

4q32

c-Myb, B-Myb, LPS, IL13


C11orf15
human


induce
11p15.3





FLT3L human
inhibit

19q13.3

IL2, IL6, IL7, IL15, b-glucan, LMP1

MSP, HGFL, MST1 human


3p21 1

RON
Ephrin
EFNA1, B61, EFL1, ECKLG, EPLG1, LERK1
human


1q21-q22


TNFa, PDX1

EFNA2, ELF-1, EPLG6, LERK6, HEK7-L
human



19p13.3





EFNA3, EFL2, EPLG3, LERK3
human



1q21-q22


 


EFNA4, EFL4, EPLG4, LERK4
human


1q21-q22





EFNA5, AF1, EFL5, RAGS, EPLG7, LERK7 human
(-)

5q21
1



EFNB1, EFL3, EPLG2, LERK2 human


Xq12





EFNB2, HTKL, EPLG5, Htk-L, LERK5
human


13q33
1




EFNB3, EFL6, EPLG8, LERK8
human


17p13.1-p11.2




SCF SCF, KITLG, MGF, Steel human, mouse, Xl
inhibit

12q22 Sl(d)
IFNg, IL1b, IL6, cAMP, glucocorticoids, b-catenin

EGF epiregulin , EREG
human



4q21.2


EWS/FLI-1

NGF BDNF human
inhibit

11p13

Brn3a/(-), VEGF, CREB, BMPs

NGFB human





TNFa


neurotrophin-3, NTF3 human


12p13 1



neurotrophin 4/5, NTF5 human


19q13.3 1


ANP ANP, atriopeptin, ANF, PND, NPPA human
induce
inhibit
1p36.2 L
dHAND, MEF2C, endothelins, vasopressin, NO, adrenomedullin, PGs, hypoxia, CRF, CGRP, PAF, relaxin, cAMP, quabain, Tc
corin

BNP, NPPB human


1p36.2 1
AIRE

CNP, NPPC human


2q24-qter

D3
insulin insulin, INS human
inhibit
induce 11p15.5

Glc, PTHrP, AIRE,


INS2
mouse, rat






AIRE

IGF2, somatomedin A human



11p15.5 L

AP1, AP2, C/EBPs, Egr1, HNF3b, p53, Sp1, WT1, GH, HBV-X, HCV, glucose, DEX, AIRE

IGF1 human
inhibit
induce 12q22-q24.1 L
AP1, Brn3aC/EBPs, E2F, FOXA2, HNF1a, NRF2, p53, Sp1, STAT5s, STAT6VDR, WT1, IL4, IL13, EGF, GH, PDGF, LPS, MtPTH, TGFb, serum, A2aR, IFNgestrogen/ER, DEX, PGE2, PGA2, cAMP/PKA, ATM, targets
PDGFR see kinases










7TM receptors, their ligands and ligand synthases
 
subgroup name species structure apoptosis NF-kB JNK/p38/AP1/Erks locus KO regulators expression
memo
Ligand Angiotensinogen, AGT (AgI, AgII) human signal peptide/AgI/AgII/Serpin
induce
induce
induce
1q42-q43 L angiotensin, TNFa, NF-kB, TTF1, PRX2, RA, NPR1 liver
targets

calcitonin, CALCA human
inhibit/enhance


11p15.2-p15.1

dorsal root ganglion

CALCA, CT, KC, CGRP, CALC1, CGRP1, CGRP-I human

enhance
inhibit
(-)?


thyroid


CGRP2, CALC2, CALCB human



11p15.2-p15.1

dorsal root ganglion


corticotropin releasing hormone, CRH human
induce
inhibit
induce
8q13 L
placenta


Endothelin-1, EDN1, ET1 human endothelinx2 inhibit/ induce
induce
induce
6p24.1 1 NF-kB, AP1, GATA2, HIF1, PPARa, CREB, p300/CBP, TNF, IL1, thrombin, TRH, Resistin, Bm, Cp, Ld, Lm, Mt, Tc, Tg, NO, leptin, shear stress, hypoxia, LPA, estrogen, D3, glucose,GATA2, PIASy lung, cardiac


Endothelin-2, EDN2 human
inhibit


1p34
LMP1


Endothelin-3, EDN3 human



20q13.2-q13.3 1 Subst.P, LPS


enkephalin, Penk human




8q23-q24

D3



GIP human



17q21.3-q22

small intestine


glucagon, GCG, GLP1, GLP2 human
inhibit

inhibit/ induce
2q36-q37 L
panceratic islets


gonadotropin-releasing hormone, LHRH, GNRH1, PIF human
inhibit/ induce

induce
8p21-p11.2 hpg IGF1



bombesin, gastrin-releasing polypeptide, GRP human
inhibit

induce/(-)
18q21
Ret
brain, lung


oxytocin, OXT human
induce


20p13 L
hypothalamus
social memory

vasopressin, neurophysin II, AVP human
inhibit

induce
20p13 DI c-Myc hypothalamus


galanin, GAL human
enhance


11q13.1 L c-Myc


gastrin, GAS human
induce
induce
induce
17q21 L TNFa, IL1


kininogen, KNG1
human Cystatinx3/bradykinin
inhibit
induce

3q27

liver, kidney


cholecystokinin, CCK human
induce
induce
induce
3p22-p21.3
bFGF, CREB, TNFa brain


MSH, POMC human



2p23.3

pituitary


neuropeptide Y, NPY human


induce
7p15.1 L AP1, AP2, NF-kB, Sp1, Stat3/JAKs, leptin, NGF, RA, ER, vaccinia virus, CaMK



pancreatic polypeptide, PP, PPY human



17q12-q21

pacreatic islets


Peptide YY, PYY
human




17q21.1
1




VIP human GLUCAx2
inhibit
inhibit

6q26-q27
Smad3, Smad4, AP1, STATs, CNTF, leptin, TGFb, MVA



PACAP, ADCYAP1 human GLUCAx2
inhibit


18p11 1 Brn3a hypothalamus


parathyroid hormone, PTH human
inhibit/induce


11p15.3-p15.1 1 Sp1, Sp3, VDR, D3, DEX thyroid


PTHrP, PTHLH human
inhibit


12p12.1-p11.2 1 Ets1, Ets2, Sp1, Smad3, TGFb, EGF, androgen, D3, E1A, PKCe epithelial


relaxin H1, RLN1 human IGF
inhibit
induce
induce
9p24.1 1



relaxin H2, RLN2 human IGF


9p24.1




relaxin H3, RLN3 human IGF


19p13.2




secretin, SCT human GLUCA


11p15.5

placenta, B, epithelial


tachykinin, TAC1 (Substance K, P, neurokinin 1,2, L) human
inhibit(P)
induce(P)
induce
7q21-q22 L
brain
Subst.P targets

thyrotropin-releasing hormone, TRH human



3q13.3-q21
ErbB4 hypothalamus


somatostatin, SST human
induce
inhibit

3q28

panceatic isletes


adrenomedullin, ADM human
inhibit

inhibit
11p15.4 1 TNFa, hypoxia, D3
placenta, lung, adipocytes


adrenomedullin 2, ADM2 human










subgroup name species structure apoptosis NF-kB JNK/p38/AP1 locus KO regulators expression
memo
adrenergic alpha R




ADRA1A, alpha 1 A human 7TM


8p21-p11.2



ADRA1B, alpha 1 B human 7TM


5q23-q32 1


ADRA1D, alpha 1 D human 7TM


20p13



ADRA2A, alpha 2 A human 7TM


10q24-q26 L progesterone

ADRA2B, alpha 2 B human 7TM


2p13-q136 1


ADRA2C, alpha 2 C human 7TM


4p16 1


angiotensin II R AT2R1, AGTR1 human 7TM


3q21-q25 L
placenta, liver, adrenal, adipocyte

AT2R2, AGTR2 human 7TM
induce


Xq22-q23 L IRF1,


APJ, AGTRL1 human 7TM


11q12 1

spinal cord


ATR2L1, AGTRL2 human 7TM


22q12.2




PAF-R, PTAFR human 7TM
inhibit
induce
1p35-p34.3
GM-CSF preB, APCs

adenosine R
ADORA2A







MVA


ADORA2B human 7TM


17p12-p11.2
VEGF, IFNg


bradykinin R BDKRB1 human 7TM


14q32.1-q32.2
FSH, IL1, TNFa, LPS


BDKRB2 human 7TM


14q32.1-q32.2 L p53, IGFBP2
targets
bombesin R bombesin-like receptor 3, BRS3 human 7TM


Xq26-q28 1


calcitonin R calcitonin receptor, CALCR human Hrm/7TM


7q21.3




CGRP R, CALCRL human Hrm/7TM


2q32.2

lung

cannabinoid R CB1, CNR1 human 7TM
induce
6q14-q15 1



CB2, CNR2 human 7TM


1p36.11



endothelin R-like EBI2 human 7TM


13q32.2
LPS, Ld, Lm,Mt, Tg, MDP, LTA, PMA, IL4, TGFb APCs, B, T, NK


ETRB, ETB, endothelin receptor  B, EDNRB human 7TM
inhibit
induce
induce
13q22 1 SCF, PDTC, relaxin, AP1, C/EBP, TNFa



ETA, EDNRa, endothelin receptor a human 7TM
inhibit
induce
induce
4q31.21
AgII


PAELR, GPR37 human 7TM


7q31 1

brain, spinal cord

 lysophosphatidic acid R GPR23 human 7TM


Xq13-q21.1


cysteinyl leukotriene

PAELR, GPR37 human 7TM


7q31

brain, spinal cord

EDG2, LPA1, LPAR1, edg-2, vzg-1, Gpcr26
human
7TM
induce

9q32


brain, spinal cord
cholecystokinin R CCK-A R, CCKAR human 7TM
inhibit


4p15.1-p15.2




gastrin R, CCKBR human 7TM


11p15.4 L c-Myc brain

GRP R GRPR human 7TM


Xp22.2-p22.13
Rb2

dopamine R D1, DRD1 human 7TM
inhibit?
inhibit
5q35.1 1   brain


D2, DRD2 human 7TM
mediate
induce
11q23 L Ye

FY FY, DARC, GPD human 7TM


1q21-q2

erythroid

glucagon R GCGR human Hrm/7TM

inhibit 17q25 1
liver, kidney


GLP1R human Hrm/7TM inhibit
induce 6p21




GLP2R human Hrm/7TM inhibit

17p13.3



glutamate R, metabolic GRM7 human 7TM


3p26.1-p25.2
HCV brain

thrombin R F2R human 7TM
induce
5q13 1 ALA



GPR7 human 7TM


10q11.2-q21.1




GPR8 human 7TM


20q13.3




GPR11, F2RL1, PAR2 human 7TM


5q13




GPR17 human 7TM


2q21

brain, spinal cord


GPR32 human 7TM


19q13.3




TG1019, OXER1, oxoeicosanoid  R
human 7TM


2p21

liver, lung


GPR81 human 7TM


12q




GPR20 human 7TM


8q24.2-q24.3




GPR31 human 7TM


6q27




GPR34 human 7TM


Xp11.4




GPR35 human 7TM


2q37.3




GPR64, HE6
human
7TM


Xp22.22

Brn3a, androgen



GPR74 human 7TM


4q21




GPR87 human 7TM


3q24

epithelial


GPR89
human
7TM



1p36.13-q31.3

ALA



GPR92 human 7TM


12p13




H963 human 7TM


3q25

T, NK


GPR65, TDAG8
human
7TM
promote


14q31-q32.1
 IL8

KiSS-1 receptor
GPR54, AXOR12; HOT7T175
human
7TM


19p13.3
(puberty)


targets
sphingosylphosphorylcholine R OGR1, GPR68 human 7TM


14q31


SPC R

GPR4 human 7TM


10q11.2-q21.1
c-Myc
SPC & LPC R
tachykinin R
TACR1, NK1R
human
7TM



2p12
1
TNFa


TACR2, NK2R, NKNAR
human
7TM



10q11-q21




TACR3, NK3R human
7TM


4q25




histamine R


H1, HRH1 human 7TM
induce
3p25 L IL4, IL12

H2, HRH2 human 7TM


3p25 L


H3, HRH3 human 7TM
regulate?


20q13.33 L androgen


H4, HRH4 human 7TM


18q11.2



melanocortin R MC2R, ACTH R, adrenocorticotropic hormone  R human 7TM


18p11.2

pituitary


MC5R human 7TM


18p11.2 1



MC1R, MSH R human 7TM


16q24.3 1



MC3R human 7TM


20q13.2-q13.3 1



MC4R, MCR R human 7TM


18q22 1


muscarinic acetylcholine R CHRM1 human 7TM


11q13 1



CHRM2 human 7TM


7`q31-q35




CHRM3 human 7TM


1q41-q44 1



CHRM4 human 7TM


11p12-p11.2 1



CHRM5 human 7TM


15q26 1


nicotinic acid  R HM74, PUMA-G, GPR109A
human 7TM


12q24.31 1 LPS,CpG, dsRNA, OX-CATNFa, IFNg myeloid

chemokine-like receptor 1
CMKLR1, DEZ, ChemR23
human
7TM


12q24.1

ARNT2

adenosine R adenosine A1 receptor, ADORA1, RDC7 human 7TM


1q32.1 L RANKL, IFNa brain, spinal cord


ADORA2A, A2a R human 7TM


22q11.23 L

targets

ADORA2B, A2b human 7TM


17p12-p11.2

sm. muscle, cardiac, epithelial


ADORA3, A3 human 7TM


1p21-p13 1


P2Y (&P2X) P2Y1, P2RY1 human 7TM
induce

induce
3q25 L

ATP, ADP

P2RY12 human 7TM


3q24-q25

brain, spinal crd
ADP

P2X1, P2RX1 human P2X
mediate


17p13.3 1 DEX APCs


P2X3 human P2X


11q12 L



P2X7, P2Z, P2RX7 human P2X
induce
induce
induce
12q24 L EMP1,2,3, PMP22


P2RX5, P2X5R human P2X


17p13.3
AdV B


P2Y2, P2RY2 human 7TM
induce


11q13.5 1 TCR, estrogen
epithlial APCs
ATP, targets

P2Y6 human 7TM


11q13.5
HIV Vpr


P2RY4 human 7TM


Xq13


UTP, UDP

FKSG79 human 7TM


Xq13.2




P2RY5 human 7TM


13q14

APCs, T, NK


P2RY10, P2Y10 human 7TM


Xq21.1
PU.1, Spi-B, MIP3
B


P2RY11 human 7TM


19p13.2




P2Y14, GPR105 human 7TM


3q21-q25

uterus, ovary
UDP-Glc, targets
humanh
subgroup name species structure apoptosis NF-kB JNK/p38/AP1 locus KO regulators expression
memo
oxytocin  R oxytocin receptor, OXTR human 7TM


3p25
VEGF, LPS

corticotropin releasing hormone R CRHR1 human Hrm/7TM


17q12-q22 1

Targets

CRFR2 human Hrm/7TM


7p15.1 L


gonadotropin-releasing hormone R GNRHR human 7TM


4q21.2

pituitary


GNRHR2 human 7TM


1q12



growth hormone releasing hormone R GHRHR human Hrm/7TM


7p14

pituitary


somatostatin R Somatostatin receptor 1, SSTR1 human 7TM


14q13




SSTR2 human 7TM


17q24
CREB


SS4R, SSTR4 human 7TM


20p11.2
P2Y2


SSTR5 human 7TM

induce 16p13.3

erythroid


SSTR2 human 7TM
induce


17q24 1



SSTR3 human 7TM
induce


22q13.1




MCHR1, SLC1, GPR24 human 7TM


22q13.2 1

MCH
galanin R galanin receptor 1, GALR1 human 7TM


18q23 L Subst.P, NF-kB, LPS, Ec


galanin receptor 2, GALR2 human 7TM
mediate?


17q25.3




galanin receptor 3, GALR3 human 7TM


22q13.1




GIPR human Hrm/7TM


19q13.3 1


leukotriene  R leukotriene B4 R, LTB4 R, P2RY7, BLTR, GPR16, BLT1
human 7TM


14q11.2-q12 L Sp1, IL13, DEX APCs, T, NK
 T cell recruitment

LTB4 R2, BLTR2 human 7TM


14q11.2-q12




LTC4 R1, CYSLTR1 human 7TM
induce induce Xq13.2-21.1 1



LTC4 R2, CYSLTR2 human 7TM


13q14.12-q21.1



GABA B R GABBR1 human 7TM


6p21.31 1
brain

metabotropic glutamate R GRM1, mGluR1 human 7TM


6q24 L
brain


GRM2, mGluR2 human 7TM


3p21.31 1
heart


GRM3, mGluR3 human 7TM


7q21.1-q21.2

brain


GRM4, mGluR4 human 7TM


6p21.3 1
cerebellum


GRM5, mGluR5 human 7TM


11q14.1 1
brain


GRM6, mGluR6 human 7TM


5q35 1



GRM7 human 7TM


3p26.1-p25.1

brain


GRM8 human 7TM


7q31.3-q32.1



neurokinin  R TACR1, NK1R (substance P receptor) human 7TM
inhibit
induce

2p12 1 NF-kB, IL1b, IL4, IL18, IL12, SCF


TACR2, NK2R human 7TM
inhibit
induce

10q11-q21




TACR3, NK3R human 7TM
inhibit
induce

4q25



neuropeptide Y R Y1, NPYR, NPY1R human 7TM


4q31.3-q32 L Brn3a, FSH fetal brain


Y2, NPY2R human 7TM


4q31 L



Y5, NPY5R human 7TM


4q31-q32




Y2B, Y6, PP2, NPY6R human 7TM


5q31



neurotenin receptor 2 NTSR2 human 7TM


2p25.1
CLOCK hypothalamus

Serotonin R HTR1A  human 7TM
inhibit?


5q11.2-q13 1
liver


HTR2B human Hrm/7TM
mediate?
induce

2q36.3-q37.1

uterus

PACAP R PACAP R (type I), ADCYAP1R1 human 7TM
inhibit


7p14
p53, Zac

opioid opioid receptor kappa 1, OPRK1 human 7TM


8q11.2 1



OPRL1, LC132 R, nociceptin R, NOCIR human 7TM


20q13.33


nociceptin

OPRD1, delta 1 human 7TM


1p36.1-p34.3




OPRM1, mu 1 human 7TM


6q24-q25



pancreatic polypeptide R Y4, PP1, NPY4R, PPYR1 human 7TM


10q11.2-q21.2 1 D3

prostaglandin R EP1, prostaglandin E receptor 1, PTGER1 human 7TM


19p13.1 L



EP2, prostaglandin E receptor 2, PTGER2 human 7TM


14q22 L ribavirin, c-Myc NK


EP3, prostaglandin E receptor 3 , PTGER3 human 7TM


1p31.2 L PDX1, AIRE


EP4, prostaglandin E receptor 4, PTGER4 human 7TM


5p13.1 L HSV1
NK, myeloid
targets

FP, PTGFR human 7TM


1p31.1 1 calcineurin uterus

formyl peptide R FPR1 human 7TM


19q13.4
LPS, hsp65, IL8
myeloid

lipotoxin A4 R
HM63, FPRH1, LXA4R, FPRL1 human 7TM


19q13.3-q13.4

neutrophil


FPRL2, FPRH2 human 7TM


19q13.3-q13.4
LPS, IL4

melatonin R melatonin receptor 1A, MTNR1A human 7TM
inhibit?


4q35.1
VEGF, GnRH, VDR, IGFBP2

RDC1 RDC1, GPR159
human 7TM


2q37.3
PRX2

HIV coR
vasopressin R AVPR1A human 7TM
inhibit?


12q14-q15




AVPR1B, AVPR3 human 7TM


1q32




AVPR2, V2R, ADHR human 7TM

induce Xq28



adrenomedullin R ADMR human 7TM


12q13.13



TRH R TRHR human 7TM


8q23
CREB hemato.

orphan TPRA40 human 7TM


3q21.2
Ye


RAIG2, GPRC5B

7TM


16p12

RA, TNFa
brain

RAMP RAMP3 human RAMP


7p13-p12
PDGF
bind to ADMR
subgroup name species structure apoptosis NF-kB JNK/p38/AP1 locus KO regulators expression
memo
brain-specific angiogenesis inhibitor BAI1 human TSP1s/GPS/7TM


8q24




BAI2 human TSP1s/GPS/7TM


1p35

brain


BAI3 human TSP1s/GPS/7TM


6q12

brain

other GPS GPR56 human ?/GPS/7TM


16q13
HCV NK


GPR126, VIGR
human
CUB/GPS/7TM



6q24.1

TNFa placenta


GPR133 human GPS/7TM


12q24.33



TSH R TSHR human LRRs/7TM


14q31 1
thyroid


LGR5, GPR49
human
LRRs/7TM



12q22-q23

HNF4a orfactory bulb

relaxin R LGR7 human LRRs/7TM


4q32 1 LPS


CD97 CD97 human EGFx5/GPS/7TM


19p13.2-p13.12
Yp, BMP2, TGFb
NK, leukocytes CD55 receptor

EMR1 human EGFx6/GPS/7TM


19p13.3
G-CSF NK, leukocytes

EMR2 human EGFx6/GPS/7TM


19p13.1

NK, leukocytes
Other Hrm parathyroid hormone (PTH)/ PTHrP R, PTHR1 human HRM/7TM mediate

3p22-p21.1 1 Sp1, MAZ, PTH, D3 kidney


PTHR2 human HRM/7TM


2q33




secretin R human HRM/7TM


2q14.1




VIP R, VIPR1, RDC1, PACAP R human HRM/7TM


3p22
progesterone


VIPR2 human HRM/7TM


7q36.3
LPS

flamingo CELSR1, FMI2 human, mouse CAx9/EGFx3/LaminG/EGF/LaminG/EGFx3/HRM/GPS/7TM


22q13.3 fmi



CELSR2, EGFL2, MEGF3 human, mouse



1p21

brain


CELSR3, FMI1, MEGF2 human, mouse, rat Cadx9/EGFx3/LamineG/EGF/LaminG/EGFx3/HRM/GPS/7TM


3p24.1-p21.2

brain

MASS1 MASS1, VLGR1 human Calx-betax22/GPS/7TM


5q13 m


calcium-sensing R CASR, PCAR1 human ANFR/7TM


3q21-q24 1


renin renin, REN human Asp protease


1q32
CREB, Pit1, AP1, NF-Y, Sp1, Sp3, Ear2, T3, D3, TNFa, AgII, cAMP, PKA, Ref1, P2Y11

ACE ACE1, ACE, DCP1, kininase II, CD143 human ACE or M2x2/TM inhibit?

17q23 L c-Myc, pleiotrophin, Ma

cleave angiotensin I, bradykinin

ACE2 human ACE


Xp22



RAMP
RAMP1
human
RAMP





D3



RAMP3
human
RAMP









See lists of chemokine receptor for chemokine receptors, C3aR & C5R1, lipid metabolism, prostaglandin, leukotriene synthesis
review of
Endothelin by Kedzierski & Yanagisawa (Annu Rev Pharmacol Toxicol 2001)
GPCRDB: Information system for G protein-coupled receptors (GPCRs)


NOTCH
 

Protein species apoptosis NF-kB KO locus
structure upstream regulators 3D casp memo
Notch Notch1, TAN1 human, mouse, rat, Xl, zebrafish, sea urchin
inhibit
inhibit L 9q34.3 Delta1 EGFx36/NLx2/TM/Ank6 Mad1, Notch, LMP1, cortisol, HHV8

targets

Notch2 human, mouse, rat, chicken, fugu, fly
inhibit

L 1p13-p11 Delta1, Jagged1, Jagged2 EGFx36/NLx2/TM/Ank6 cortisol, RA



Notch3 human, mouse, rat
inhibit
activate 1 19p13.2-p13.1
EGFx34//NLx3/TM/Ank6 BMP2, Egr1, Cdx2TNFa, Pg




Notch4 human, mouse,
inhibit


6p21.3

UVB, c-Myc


Delta-1 Delta1, DLL1 human, mouse, rat, zebrafish

L 6q27
EGFx10/TM ARNT2



DLK1, PREF1, FA1, pG2 human, mouse, rat, bovine


14q32






DLL3 human, mouse


19q13






DLL4 human, mouse


15q14






Jagged-1, JAG1 human


20p12
EGFx18/VWC/TM TNFa, IL1, IL13, LPS,MDP, AgII, PTH, IGFBP2



Jagged-2, JAG2 human


14q32

LMP1, Stat4


Deltex
Deltex 1 , DTX1
human



12q24.21
Grb2

Cdx2, Notch



Deltex 2, DTX2
human


7q11.23


AIRE



Deltex 3, DTX3
human


12q13.2







Deltex 4, DTX4
human


11q12.2






CBF1 CBF1, RBPJK, IGKJRB1,LAG2, RBPSUH human


9p13-p12 Notch TIG




RBP-L, RBPSUHL human


20q12-q13.1





nicastrin nicastrin human, mouse, Dm, Ce


1q22-q23 PSs, BACE1 aminopeptidase/TM



presenilin see other apoptosis regulators










BACE
human

L 11q23.2-q23.3

Hp


HEY
for hairy enhancer-of-split, see TFs
Regulation of T cell fate by Notch. (Robey E 1999)


Review by Darnell  (Science 1997 )
Other factors

EGF
family name species apoptosis locus upstream regulators memo
EGF amphiregulin human
4q13-q21 PTH, Hp

 
family name species apoptosis locus upstream regulators memo
FGF see ILs



anti-BMP4 function
SHIP SHIP human induce


SPARC
human
5q31.3-q32 EDA

 
family name species apoptosis upstream regulators memo
FSH FSH human inhibit
targets
FSHR FSHR human
USFs, SF1, PKA

GDNF targets

Reelin/Disabled
 
Group Protein Species KO apoptosis locus structure bound upstream regulators
Disabled Disabled-1, DAB1 human 1
1p32-p31 PTB Pcdh18

Disabled-2, DAB2 human

5p13 PTB
ICSBP, TGFb
Reelin Reelin, RELN human 1
7q22 Reelin/[BNR/EGF/BNR]x7
BDNF, AIRE
ApoE R ApoE R2 ,  LRP8 human

1p34 LDLx7/EGFx2/LYx6/EGF/TM/(pY) Disabled

 

Group Protein Species KO apoptosis locus structure bound upstream regulators
LECT2
LECT2, leukocyte cell-derived chemotaxin 2, chondromodulin-II, mim-1
human, mouse, rat, bovine, chicken, fugu, Ce,
1
5q31.1-q32 LECT2




Review of JAK by Mathey-Prevot & Perrimon
 
 



Online References
Review
[General]
Dimerization as a regulatory mechanism by Klemm et al. (Annu. Rev. Immunol. 1998)




Vector Sequences
 
Lafmid BA
pBluescript II SK(-), Stratagene original homepage of Bluescript series
pBK-CMV
pCMV-SPORT
pCMVSPORT6
pECFP-C1
pEYFP-C1 (strong F)
pET30a(+)  (Map)
pME18S-FL3
pOT2 (Chloramphenicol 12.5 mg/l)
pOTB7
pSPORT1
pT7T3D-PAC
Other from IMAGE
pMSCV-puro
pMSV-neo
pMSV-hygro
Other Clontech (BD) vectors

Promega plasmids

 


 
Cytokines Online Pathfinder Encyclopaedia
Cell Signaling Networks Database
The Promoter Database of Saccharomyces cerevisiae
List of E. coli Transcription Factors



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