Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet
  •  NF-kB, Apoptosis & JNK Regulators

    •  
    family name KO gene Locus NF-kB Apoptosis JNK, AP-1, Erk, p38
    		 Binding Receptors/ Ligands Binding partner consensus Structure 3D tramscriptional regulators upstream regulators expression
    		 memo
    TRAF TRAF1,  EBI6(human, mouse) 1 1 9q33-q34 inhibit/activate
    inhibit
    		 induce TNFR2, CD30,  4-1BB, OX40, LMP-1, ATAR /HVEM, p75NTR TRADD, RIP, RICK, cIAPs, CASPER, A20, CLARP, TRAF1,2, FADD, I-TRAF/TANK, TRIP, NIK, KRC PVQET
    HI  S    		 TRAF-N(cc)/MATH
    		NF-kB, AP-1 IL1R, CD40, TNFa, IL1, RANKL, dsRNA, LPS, LTA, Bm, Hp, Ld, Lm, LLO,  Mt, Tg, MDP, PMA, YopP, IL10, EBV, NO, AmB
    		casp, Ub
    TRAF2, TRAP (human, mouse) L 1 9q34 activate
    inhibit
    		 induce TNFR2, CD30,  4-1BB, OX40, CD27, CD40, LMP-1, p75NTR, Siah2
    		 A20, CLARP, TRADD, RIP, cIAPs, TRAF1, 2, 5, FADD, I-TRAF/TANK, TRIP, NIK, MEKK1, MEKK1, caveolin-1, NS5A, sphingosine kinase, Ask1, T2BP,  TRIP6, PKR
    		 PVQET
    HI  S
     t    		 RING/coil-coil/MATH 1,2,3, 4, TRADD-N/TRAF2 NF-kB CD40, M-CSF, LPS, ribavirin, TCDD
    		Ub
    TRAF3, LAP1, CRAF1,  TRAFamn,  CAP1  (human, mouse) 1 1 14q32 activate
    (promote)
    		 induce CD27, CD30, CD40, 4-1BB, OX40, LTbR, HEV/ATAR, LMP-1, p75NTR TRAF3, I-TRAF/TANK, Act1, NIK, MIP-T3 PVQET
    HI  S
    G

    xVQXT
     IF S
     MW
     F

    		 RING/coil-coil/MATH 1, /w TANK E2F1 LPS, Hp, IL1, GCSF, TNFa, Fas, HCV, UVB, Epo, camptothecin, cantharidin
    		casp
    TRAF4, MLN64, CART1(human, mouse) L 1 17q11-q12 activate/inhibit
    modulate
    		 induce
    		p47phox
    		RING/Zn/coil-coil/MATH
    		HNF4a, p53
    		 PTEN, BMPs, EV71

    TRAF5 (human,mouse) L 1 1q32 activate
    		induce CD27, CD30, CD40, OX40, LTbR, HEV/ATAR, LMP-1, p75NTR TRAF5, RICK, NIK, Ask1,  PKR
    		RING/Zn/coil-coil/MATH

    		Rb2, LPS, Camptothecin, Fas

    TRAF6 (human,mouse) L 1 11p11.2 activate regulate induce CD40,IL1R, p75NTR Ubc13/Uev1A, IRAK,IRAK2, IRAK-M, RICK, NIK, T6BP, KCNQ1,Tab2, TTRAP, Act1, Ask1, Pellino, MAST205
    		 QxPxExxF
    N A    W
    R      Y    		 RING/Zn/coil-coil/MATH
    		AIRE IFNa, IFNb, IFNg, Fas, LPS, Hi, Lm, UV, camptothecin
    		Ub
    TRAF7, see RFWD1 in RING
    		 activate
    		activate








    CeTRAF/TRF-1(C.elegans) 1 1






    		RING/Zn/coil-coil/MATH




    TRAF1(D.m.)  1 1 2 24E5-24F1
    induce
    mediate
    		Misshapen, Pelle
    		Zn/coil-coil/MATH

    		DIAP1

    TRAF2(D.m.), TRAF6(D.m.) 1 1 1 7D12-7D15
    induce


    		Pelle, KRC, Wengen
    		RING/Zn/coil-coil/MATH




    TRAF related (MATH)
    		 Meprin[human(a, al1, al2, al3, al4), mouse]
    		1 6p21.2-p21.1(a)





    		ZnMc/MAM/MATH/EGF/TM


    		kidney, intestine
    		 metallopeptidase

    		DG17(D.d.)








    		RING/ZnF/cc/MATH





    		USP7 see USPs
    		1






    		MATH/UCH1/UCH2





    		MUL, TRIM37 (human) d 1 17q22-q23





    		RING/B box/MATH


    		brain

    		SPOP(human), A.t.,(T5I7.6, At3g03740, At3g06190, At3g43700,)
    		1 17q21.31





    		MATH/BTB


    		ubiquitous
    CC only
    		 ELKS, ERC1, CAST2, RAB6IP2 (human, mouse, rat)

    		12p13.3
    		 mediate


    		Rab6, IKKs, liprin-a1,

    		coiled-coil


    		ubiquitous
    CAST, ERC2 (human, mouse, rat)

    		3p21.31



    		RIM1, liprin-a1, Munc13-1




    		brain
    ABIN1, NAF1, VAN, TNIP1 (human, mouse L,S)
    		1 5q32-q33.1
    inhibit


    		A20, Nef
    		coiled-coil

    		LPS, MDP, TNFa
    		 ubiquitous
    		 CD4 downreg.
    ABIN2, TNIP2 (human, mouse)

    		4p16.3
    inhibit


    		A20, IKKg, COT, p105
    		coiled-coil

    		Ye ubiquitous
    taxilin, DKFZp451J0118 (human)

    		1p34.3



    		IKKg, syntaxins
    		coiled-coil


    		ubiquitous
    PAR-4, PAWR (human, mouse, rat) 1 1 12q21
    inhibit
    promote
    mediate
    		DLK, WT1, AATF, PKCzeta, lambda
    		coiled-coil
    		AP1, E2F1 Ras, Ca ubiquitous
    Nemo Nemo (mouse), IKKgamma, IKKAP1, FIP3(human), fly L 1 Xq28
    mediate/inhibit
    induce

    		IKKa, IKKb, IKKg, RICK, RIP, NIK, CYLD, E3 14.7K, Tax, Act1, CARP1, APG16L, taxilin, hsp70, CDC37/Hsp90, A20, ABIN2, ZNF216, E10, Asc, TBK1, TANK
    		coiled-coil/ZnF

    		EDA ubiquitous
    		 targets(B), Ub
    FIP2/HYPL /NRP/ optineurin / OPTN(human) POAG 1,2 10p13
    (-)
    promote

    		E3 14.7K, huntingtin, Rab8, p85, p180 kinases
    		coiled-coil/ZnF
    		  TNF, Fas

    I-TRAF(human, mouse), TANK (human, mouse)
    		1,2 2q22-23 activate/inhibit


    		TRAFs, TBK1, IKKi, IKKg
    		coiled-coil/ZnF /w TRAF3 AIRE camptothecin, LPS, Hf, hsp65 ubiquitous
    AZ2 (mouse) 1 1 3
    inhibit/activate
    inhibit

    		TBK1
    		coiled-coil/ZnF


    		ubiquitous
    Tab2(human, mouse, rat, Dm) L 1,2 6q25.1-q25.3
    induce
    inhibit
    		 induce
    		TAK1, TRAF6, citrate synthase, polyUb
    		CUE/coiled-coil/ZnF

    		IL2 ubiquitous
    Tab3, NAP1 (human, mouse, rat, Xl, )

    		Xp21.3
    induce


    		TAK1, TRAF2, TRAF6, polyUb
    		CUE/coiled-coil/ZnF


    		ubiquitous Ub
    TXBP151, TAX1BP1, T6BP(human L), MDP62(chicken)
    		1 7p15
    (-)
    (promote)
    (-)
    		tax, TRAF6, A20, T6BP
    		coiled-coil/ZnF

    		Fas, IL3, camptothecin ubiquitous casp, neurite
    Act1 Act1/CIKS(human)
    		1 6q21-22.1
    induce
    		induce
    		IKKs, TRAF3, TRAF6


    		IRF1 TNFa, IL1, TGFb ubiquitous
    TRUSS TRRP4AP, TRUSS (human, mouse, zebrafish)

    		20q11.23
    activate


    		TNFR1, RIN2, TRP4




    		ubiquitous
    NKAP NKAP, FLJ22626 (human, mouse, Dm, Ce, At)

    		Xq25
    induce


    		RIP




    		ubiquitous

    		C6orf194 (human)

    		6p21.33











    SANT FLASH, RIP25, CASP8AP2 (human, mouse) 1 1,2 6pter-q16.2
    activate
    mediate

    		Caspase-8, FADD, E1B 19K, p160
    		SANT, no homo. to Ced4/DED


    		ubiquitous
    KIAA1606 (human)

    		1q23.1





    		SANT


    		ubiquitous
    TRF1, TERF1, Pin2 (human)

    		8q13
    induce

    		TTAGGG
    		SANT


    		ubiquitous
    TRF2 (human)

    		16q22.1
    inhibit



    		SANT 1

    		testis
    also EZH1 see in TFs














    SIMPL SIMPL, AIP70(mouse)
    		1 6q14
    induce


    		IRAK, IKKs, ActA




    		ubiquitous
    MIP-T3 MIP-T3, TRAF3IP1(human),  CG3259(fly), C02H7.1(C.e.)
    		1 2q37.3



    		TRAF3, tubulin
    		?/coiled-coil


    		ubiquitous CD40
    LMP-1 LMP-1(EBV)


    induce
    inhibit

    		TRAFs, A20





    		targets
    IKAP human, S.c.[IKI3], S.p.[SPBC36.07], A.t.[]

    		9q34 activate/inhibit


    		NIK, IKKs?(see memo)
    		WD-like x5


    		ubiquitous transcription elongation factor subunit?
    TNAP
    		 TNAP (human)


    		inhibit


    		NIK, TRAF2, TRAF3





    		encoded by repetitive sequences
    WD40R beta-TrCP and other F-box proteins, see E3

    		     



    		F box/WD40




    RACK1(human)

    		5q35.3
    inhibit

    		PKCs, IFN-R2, E1A, p120GAP, Nef, Src, BZLF1, M1, PDE4D5, integrin b,
    		WD40x7

    		PKCe,  B, T
    hAn11 (human, yeast)

    		17q24.2



    		MEKK1
    		WD40x5


    		B, T
    APG16L (human)

    		2q37.1



    		IKKg
    		cc/WD40x7


    		ubiquitous
    Ub-BP p62/p60/Zip/Osi, SQSTM1 (human, mouse)

    		5q35
    induce


    		Ubiquitin, Lck, RIP, EBI3, TrkA, TRAF6
    		OPA/ZnF/UbA
    		c-Myc PMA, PDGF, serum

    signalosome/ proteasome component & related COPS3/CSN3(human, fly, A.t.)

    		17p11.2
    inhibit


    		IKKgamma
    		/PCI(PINT)


    		bm

    		GPS1(human), FUS6/COP11(A.t.)

    		17q25.3





    		/PCI


    		ubiquitous

    		TRIP15(human)

    		15q21.2



    		TRs, RXRa, ICSBP
    		/PCI


    		ubiquitous

    		RPN3(human)

    		17pter-p13.1





    		/PCI


    		preB

    		COPS7A(human)

    		12pter-p13.31





    		/PCI


    		ubiquitous

    		COPS7B/FLJ12612(human)

    		2p24.3-p24.1





    		/PCI


    		B, T, NK

    		S9, PSMD11(human)

    		17q11.2
    mediate


    		NFkB2
    		/PCI

    		estrogen ubiquitous

    		PSMD12(human)

    		17q24.2





    		/PCI


    		ubiquitous

    		PSMD13/HSPC027/p40.5(human)

    		11p15.5





    		/PCI





    		COPS4(human)

    		4q21.21-q21.23





    		/PCI





    		p44S10/KIAA0107(human)

    		3p23-cen





    		/PCI





    		PNAS125/GA17(human)

    		11p13





    		/PCI





    		eIF3-p48/Int6(human)

    		8q22-q23





    		/PCI





    		eIF3-p110(human)

    		16p11.2





    		/PCI





    		PMSA4 (human)











    		estrogen


    		PMSB3 (human)











    		estrogen


    		PMSB6 (human)











    		estrogen


    		PMSD8 (human)











    		estrogen


    		PMSC4 (human)











    		estrogen


    		Jab1/SGN5/COPS5(human)

    		8q12.3

    		activate
    		Bcl3, MIF, PR, SRC-1, Integrin LFA-1, LHR
    		Mov34


    		ubiquitous IkBa, AP1, p27Kip1, ICSBP

    		LMPX, PSMB5 (human)

    		14q11.2








    		IFNg, LPS, SCF, hsp65


    		LMP7, RING10, PSMB8 (human)

    		6p21.3








    		IFNg, IFNa, LPS, HCV, hsp65


    		LMP2, RING12, PSMB9 (human) 1
    		6p21.3








    		IFNa, IFNg, HCV

    Zn Finger proteins XAF1, HSXIAPAF1 (human)

    		17p13.2  
    inhibit

    		XIAP1
    		/ZnF/

    		HCV, Nef, CD28, CsA, IFNa, IFNb hemato.

    		TIZ (human)

    		19p11
    inhibit


    		TRAF6
    		ZnFx14


    		ubiquitous

    		Fln29(human)

    		12q



    		TRAFs
    		/ZnF/

    		IFNb, IL2 ubiquitous


    		TLS/FUS(human)

    		16p11.2
    enhance
    (inhibit)

    		RelA
    		RRM/ZnF


    		ubiquitous

    		F45G2.j(C.elegans)














    LIM (ZnF) zyxin (human) 1
    		7q32



    		LATS1,
    		P-rich/LIMx3





    		TRIP6, OIP1, ZRP-1 (human)

    		7q22
    		 enhance
    		enhance
    		TR, RXR, Endoglin, LPA2, PTP1E, RICK, TRAF2, Nod1, IL1R1, TLR2, Opa
    		P-rich/LIMx3





    		LPP (human)

    		3q28





    		P-rich//LIMx3




    BRE
    		 BRE (human, mouse, rat, Xl, At, rice)

    		2p23.2 inhibit
    		 inhibit






    		RA, DNA damage

    FHA T2BP, TIFA (human, mouse)

    		4q25
    induce
    		(induce)
    		TRAF2, TRAF6, IRAK1
    		FHA


    		ubiquitous

    		TIFAB (human, mouse)


    		inhibit










    IEX-1
    		 IEX-1L(human)