Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| Index | Caspase | CARD/DED/BIR | Bcl-2 | DD | TNF/TNFR | Kinases | ILs | Viral | Lipid | Engulf | TF | RING | Toll | Other Apop | Other NFkB | Alphabet |
| family | name | KO | gene | Locus | NF-kB | Apoptosis | JNK, AP-1, Erk, p38 |
Binding Receptors/ Ligands | Binding partner | consensus | Structure | 3D | tramscriptional regulators | upstream regulators | expression |
memo |
| TRAF | TRAF1, EBI6(human, mouse) | 1 | 1 | 9q33-q34 | inhibit/activate |
|
induce | TNFR2, CD30, 4-1BB, OX40, LMP-1, ATAR /HVEM, p75NTR | TRADD, RIP, RICK, cIAPs, CASPER, A20, CLARP, TRAF1,2, FADD, I-TRAF/TANK, TRIP, NIK, KRC | PVQET HI S |
TRAF-N(cc)/MATH | NF-kB, AP-1 | IL1R, CD40, TNFa, IL1, RANKL, dsRNA, LPS, LTA, Bm, Hp, Ld, Lm, LLO, Mt, Tg, MDP, PMA, YopP, IL10, EBV, NO, AmB | casp,
Ub |
||
| TRAF2, TRAP (human, mouse) | L | 1 | 9q34 | activate |
|
induce | TNFR2, CD30, 4-1BB, OX40, CD27, CD40,
LMP-1, p75NTR, Siah2 |
A20, CLARP, TRADD, RIP, cIAPs, TRAF1, 2, 5, FADD,
I-TRAF/TANK, TRIP,
NIK, MEKK1, MEKK1,
caveolin-1, NS5A,
sphingosine kinase, Ask1,
T2BP,
TRIP6,
PKR |
PVQET HI S t |
RING/coil-coil/MATH | 1,2,3, 4, TRADD-N/TRAF2 | NF-kB | CD40, M-CSF, LPS, ribavirin, TCDD | Ub | ||
| TRAF3, LAP1, CRAF1, TRAFamn, CAP1 (human, mouse) | 1 | 1 | 14q32 | activate |
|
induce | CD27, CD30, CD40, 4-1BB, OX40, LTbR, HEV/ATAR, LMP-1, p75NTR | TRAF3, I-TRAF/TANK, Act1, NIK, MIP-T3 | PVQET HI S G xVQXT |
RING/coil-coil/MATH | 1, /w TANK | E2F1 | LPS, Hp, IL1, GCSF, TNFa, Fas, HCV, UVB, Epo, camptothecin, cantharidin | casp | ||
| TRAF4, MLN64, CART1(human, mouse) | L | 1 | 17q11-q12 | activate/inhibit |
|
induce | p47phox | RING/Zn/coil-coil/MATH | HNF4a,
p53 |
PTEN, BMPs, EV71 | ||||||
| TRAF5 (human,mouse) | L | 1 | 1q32 | activate | induce | CD27, CD30, CD40, OX40, LTbR, HEV/ATAR, LMP-1, p75NTR | TRAF5, RICK, NIK, Ask1,
PKR |
RING/Zn/coil-coil/MATH | Rb2, LPS, Camptothecin, Fas | |||||||
| TRAF6 (human,mouse) | L | 1 | 11p11.2 | activate | regulate | induce | CD40,IL1R, p75NTR | Ubc13/Uev1A,
IRAK,IRAK2, IRAK-M,
RICK,
NIK, T6BP, KCNQ1,Tab2,
TTRAP, Act1,
Ask1,
Pellino,
MAST205 |
QxPxExxF N A W R Y |
RING/Zn/coil-coil/MATH | AIRE | IFNa, IFNb, IFNg, Fas, LPS, Hi, Lm, UV, camptothecin | Ub | |||
| TRAF7, see RFWD1 in RING |
activate | activate | ||||||||||||||
| CeTRAF/TRF-1(C.elegans) | 1 | 1 | RING/Zn/coil-coil/MATH | |||||||||||||
| TRAF1(D.m.) | 1 | 1 | 2 24E5-24F1 |
|
|
Misshapen, Pelle | Zn/coil-coil/MATH | DIAP1 | ||||||||
| TRAF2(D.m.), TRAF6(D.m.) | 1 | 1 | 1 7D12-7D15 |
|
Pelle, KRC, Wengen | RING/Zn/coil-coil/MATH | ||||||||||
| TRAF related (MATH) |
Meprin[human(a, al1, al2, al3, al4), mouse] | 1 | 6p21.2-p21.1(a) | ZnMc/MAM/MATH/EGF/TM | kidney, intestine |
metallopeptidase |
||||||||||
| DG17(D.d.) | RING/ZnF/cc/MATH | |||||||||||||||
| USP7 see USPs | 1 | MATH/UCH1/UCH2 | ||||||||||||||
| MUL, TRIM37 (human) | d | 1 | 17q22-q23 | RING/B box/MATH | brain |
|||||||||||
| SPOP(human), A.t.,(T5I7.6, At3g03740, At3g06190, At3g43700,) | 1 | 17q21.31 | MATH/BTB | ubiquitous |
||||||||||||
| CC only |
ELKS, ERC1, CAST2, RAB6IP2 (human,
mouse,
rat) |
12p13.3 |
mediate |
Rab6,
IKKs, liprin-a1,
|
coiled-coil | ubiquitous |
||||||||||
| CAST, ERC2 (human,
mouse,
rat) |
3p21.31 |
RIM1,
liprin-a1,
Munc13-1 |
brain |
|||||||||||||
| ABIN1,
NAF1,
VAN, TNIP1 (human,
mouse
L,S) |
1 | 5q32-q33.1 |
|
A20, Nef | coiled-coil | LPS,
MDP,
TNFa |
ubiquitous |
CD4 downreg. | ||||||||
| ABIN2, TNIP2 (human, mouse) | 4p16.3 |
|
A20,
IKKg, COT,
p105 |
coiled-coil | Ye | ubiquitous | ||||||||||
| taxilin, DKFZp451J0118 (human) | 1p34.3 | IKKg, syntaxins | coiled-coil | ubiquitous | ||||||||||||
| PAR-4, PAWR (human, mouse, rat) | 1 | 1 | 12q21 |
|
|
|
DLK, WT1, AATF, PKCzeta, lambda | coiled-coil | AP1, E2F1 | Ras, Ca | ubiquitous | |||||
| Nemo | Nemo (mouse), IKKgamma, IKKAP1, FIP3(human), fly | L | 1 | Xq28 |
|
|
IKKa, IKKb, IKKg, RICK, RIP, NIK, CYLD, E3 14.7K, Tax, Act1, CARP1, APG16L, taxilin, hsp70, CDC37/Hsp90, A20, ABIN2, ZNF216, E10, Asc, TBK1, TANK | coiled-coil/ZnF | EDA | ubiquitous |
targets(B), Ub | |||||
| FIP2/HYPL /NRP/ optineurin / OPTN(human) | POAG | 1,2 | 10p13 |
|
|
E3 14.7K, huntingtin, Rab8, p85, p180 kinases | coiled-coil/ZnF | TNF, Fas | ||||||||
| I-TRAF(human, mouse), TANK (human, mouse) | 1,2 | 2q22-23 | activate/inhibit | TRAFs, TBK1, IKKi, IKKg | coiled-coil/ZnF | /w TRAF3 | AIRE | camptothecin, LPS, Hf, hsp65 | ubiquitous |
|||||||
| AZ2 (mouse) | 1 | 1 | 3 |
|
|
TBK1 | coiled-coil/ZnF | ubiquitous |
||||||||
| Tab2(human, mouse, rat, Dm) | L | 1,2 | 6q25.1-q25.3 |
|
|
induce | TAK1,
TRAF6,
citrate
synthase, polyUb |
CUE/coiled-coil/ZnF | IL2 | ubiquitous | ||||||
| Tab3, NAP1 (human, mouse, rat, Xl, ) | Xp21.3 |
|
TAK1,
TRAF2,
TRAF6,
polyUb |
CUE/coiled-coil/ZnF | ubiquitous | Ub | ||||||||||
| TXBP151, TAX1BP1, T6BP(human L), MDP62(chicken) | 1 | 7p15 |
|
|
|
tax, TRAF6, A20, T6BP | coiled-coil/ZnF | Fas, IL3, camptothecin | ubiquitous | casp, neurite | ||||||
| Act1 | Act1/CIKS(human) | 1 | 6q21-22.1 |
|
induce | IKKs, TRAF3, TRAF6 | IRF1 | TNFa, IL1, TGFb | ubiquitous | |||||||
| TRUSS | TRRP4AP, TRUSS (human, mouse, zebrafish) | 20q11.23 |
|
TNFR1, RIN2, TRP4 | ubiquitous | |||||||||||
| NKAP | NKAP, FLJ22626 (human, mouse, Dm, Ce, At) | Xq25 |
|
RIP | ubiquitous | |||||||||||
| C6orf194 (human) | 6p21.33 | |||||||||||||||
| SANT | FLASH, RIP25, CASP8AP2 (human, mouse) | 1 | 1,2 | 6pter-q16.2 |
|
|
Caspase-8, FADD, E1B 19K, p160 | SANT, no homo. to Ced4/DED | ubiquitous | |||||||
| KIAA1606 (human) | 1q23.1 | SANT | ubiquitous | |||||||||||||
| TRF1, TERF1, Pin2 (human) | 8q13 |
|
TTAGGG | SANT | ubiquitous | |||||||||||
| TRF2 (human) | 16q22.1 |
|
SANT | 1 | testis |
|||||||||||
| also EZH1 see in TFs | ||||||||||||||||
| SIMPL | SIMPL, AIP70(mouse) | 1 | 6q14 |
|
IRAK, IKKs, ActA | ubiquitous | ||||||||||
| MIP-T3 | MIP-T3, TRAF3IP1(human), CG3259(fly), C02H7.1(C.e.) | 1 | 2q37.3 | TRAF3, tubulin | ?/coiled-coil | ubiquitous | CD40 | |||||||||
| LMP-1 | LMP-1(EBV) |
|
|
TRAFs, A20 | targets | |||||||||||
| IKAP | human, S.c.[IKI3], S.p.[SPBC36.07], A.t.[] | 9q34 | activate/inhibit | NIK, IKKs?(see memo) | WD-like x5 | ubiquitous | transcription elongation factor subunit? | |||||||||
| TNAP |
TNAP
(human) |
inhibit |
NIK,
TRAF2,
TRAF3 |
encoded by repetitive sequences |
||||||||||||
| WD40R | beta-TrCP and other F-box proteins, see E3 | F box/WD40 | ||||||||||||||
| RACK1(human) | 5q35.3 |
|
PKCs, IFN-R2, E1A, p120GAP, Nef, Src, BZLF1, M1, PDE4D5, integrin b, | WD40x7 | PKCe, | B, T |
||||||||||
| hAn11 (human, yeast) | 17q24.2 | MEKK1 | WD40x5 | B, T |
||||||||||||
| APG16L (human) | 2q37.1 | IKKg | cc/WD40x7 | ubiquitous | ||||||||||||
| Ub-BP | p62/p60/Zip/Osi, SQSTM1 (human, mouse) | 5q35 |
|
Ubiquitin,
Lck,
RIP,
EBI3,
TrkA,
TRAF6 |
OPA/ZnF/UbA | c-Myc | PMA, PDGF, serum | |||||||||
| signalosome/ proteasome component & related | COPS3/CSN3(human, fly, A.t.) | 17p11.2 |
|
IKKgamma | /PCI(PINT) | bm |
||||||||||
| GPS1(human), FUS6/COP11(A.t.) | 17q25.3 | /PCI | ubiquitous | |||||||||||||
| TRIP15(human) | 15q21.2 | TRs, RXRa, ICSBP | /PCI | ubiquitous | ||||||||||||
| RPN3(human) | 17pter-p13.1 | /PCI | preB |
|||||||||||||
| COPS7A(human) | 12pter-p13.31 | /PCI | ubiquitous | |||||||||||||
| COPS7B/FLJ12612(human) | 2p24.3-p24.1 | /PCI | B, T, NK |
|||||||||||||
| S9, PSMD11(human) | 17q11.2 |
|
NFkB2 | /PCI | estrogen | ubiquitous | ||||||||||
| PSMD12(human) | 17q24.2 | /PCI | ubiquitous | |||||||||||||
| PSMD13/HSPC027/p40.5(human) | 11p15.5 | /PCI | ||||||||||||||
| COPS4(human) | 4q21.21-q21.23 | /PCI | ||||||||||||||
| p44S10/KIAA0107(human) | 3p23-cen | /PCI | ||||||||||||||
| PNAS125/GA17(human) | 11p13 | /PCI | ||||||||||||||
| eIF3-p48/Int6(human) | 8q22-q23 | /PCI | ||||||||||||||
| eIF3-p110(human) | 16p11.2 | /PCI | ||||||||||||||
| PMSA4 (human) |
estrogen | |||||||||||||||
| PMSB3 (human) |
estrogen | |||||||||||||||
| PMSB6 (human) |
estrogen | |||||||||||||||
| PMSD8 (human) | estrogen | |||||||||||||||
| PMSC4 (human) |
estrogen | |||||||||||||||
| Jab1/SGN5/COPS5(human) | 8q12.3 | activate | Bcl3, MIF, PR, SRC-1, Integrin LFA-1, LHR | Mov34 | ubiquitous | IkBa, AP1, p27Kip1, ICSBP | ||||||||||
| LMPX, PSMB5 (human) | 14q11.2 | IFNg, LPS,
SCF,
hsp65 |
||||||||||||||
| LMP7, RING10, PSMB8 (human) | 6p21.3 | IFNg, IFNa,
LPS,
HCV,
hsp65 |
||||||||||||||
| LMP2, RING12, PSMB9 (human) | 1 | 6p21.3 | IFNa, IFNg, HCV | |||||||||||||
| Zn Finger proteins | XAF1, HSXIAPAF1 (human) | 17p13.2 |
|
XIAP1 | /ZnF/ | HCV, Nef, CD28, CsA, IFNa, IFNb | hemato. |
|||||||||
| TIZ (human) | 19p11 |
|
TRAF6 | ZnFx14 | ubiquitous | |||||||||||
| Fln29(human) | 12q | TRAFs | /ZnF/ | IFNb, IL2 | ubiquitous |
|||||||||||
| TLS/FUS(human) | 16p11.2 |
|
|
RelA | RRM/ZnF | ubiquitous |
||||||||||
| F45G2.j(C.elegans) | ||||||||||||||||
| LIM (ZnF) | zyxin (human) | 1 |
7q32 | LATS1, | P-rich/LIMx3 | |||||||||||
| TRIP6, OIP1, ZRP-1 (human) |
7q22 |
enhance |
enhance |
TR,
RXR,
Endoglin,
LPA2,
PTP1E,
RICK,
TRAF2,
Nod1, IL1R1,
TLR2, Opa |
P-rich/LIMx3 |
|||||||||||
| LPP (human) |
3q28 |
P-rich//LIMx3 | ||||||||||||||
| BRE |
BRE (human, mouse, rat, Xl, At, rice) | 2p23.2 | inhibit |
inhibit |
RA,
DNA
damage |
|||||||||||
| FHA | T2BP, TIFA (human, mouse) | 4q25 |
|
(induce) | TRAF2, TRAF6, IRAK1 | FHA | ubiquitous | |||||||||
| TIFAB (human,
mouse) |
inhibit |
|
||||||||||||||
| IEX-1 |
IEX-1L(human) | activate |
|
NF-kB | not physiological | |||||||||||
| IEX-1S, DIF2, PRG1, IER3, (human, mouse) | 6p21.3 |
|
ERKs | NF-kB, Nef, p53, PLZF, AP4, Sp1, c-Myb, Stat4 | MIS, KiSS1, TNF, Fas, PMA, LPS, MDP, LTA, Ct, Ec, Lm, Ma, Ye, HHV8, UV, Sox, p300, BMP2, estrogen, D3 | ubiquitous (highest in lung) |
||||||||||
| family | name | KO | gene | Locus | NF-kB | Apoptosis | JNK/AP-1 | Binding partner | Structure | 3D | tramscriptional regulators | upstream regulators | expression |
memo |
| Dok1 | Dok1, p62Dok (human) | 2p13 |
|
|
Ras-GAP, Csk, and Nck, Crk-L, Smad3 | IKKb |
ubiquitous | |||||||
| SH2D1A | SH2D1A (human) | Xq25 |
|
Dok1 | T, NK |
|||||||||
| SH2 | BLNK, SLP65 (human, mouse) | L | 10q23.2 |
|
mediate | mediate | BCR, PLCgamma,Vav, Nck, Grb2, CD72, SHP1, HPK1, | SH2 | P-Tyr | BCR, Syk | B, DC |
IP3, NF-AT, Rac1-JNK | ||
| MIST, CLNK (human, mouse) | 4q16.1 | induce | IL2 | TCR | ubiquitous | |||||||||
| CISH (human) | 3p21.3 | SH2 | IL2, IL4, IL6, IL13 | ubiquitous | ||||||||||
| SHB (human) | 9p12-p11 | SLP76, GADS, VAV1 | c-Myb | ubiquitous | ||||||||||
| Shc, SHC1 (human) |
L |
1q21 |
PTB/SH2 |
Brn3a | EV71 | |||||||||
| SLP76, LCP2(human) | L | 5q33.1-qter |
|
|
Grb2, Vav, p85, GRAP, Nck, SHP1, GADS, Lck, Hpk1, Fyb, Shb, PLCg1, PLCg2, ZAP70 | SAM/SH2 | IL2, IL5, TCR, PMA, LPS, St, LiCl | T, NK, APCs |
NF-AT,T, myeloid | |||||
| GRB2 (human), Drk (Dm), cem-5 (Ce) | 1 | 17q24-q25 |
|
EGFRs, PDGFRs, Shc, Sos, SLP76, Gab1, IRS1, | SH3/SH2/SH3 | hemato. |
||||||||
| GADS, GRID, GrpL, Grf40, Grap2 (human) | 1 | 22q12-qter | Gab1, CD28, SOS2, SLP76, Shb, DOK1, HPK1, RACK1, | SH3/SH2/SH3 | T, NK |
|||||||||
| DAPP1, Bam32 (human) | 1 | 4q25-q27 |
|
|
|
LPS | SH2/PH | IRF4, Hoxd10 | ubiquitous (highest in B) |
|||||
| NCKalpha, NCK1 (human) | 3q21 | HGK, SLP76 | SH3x3/SH2 | TNFa | hemato. (highest in NK) |
|||||||||
| NCKbeta, NCK2, GRB4 (human) | 2q12 | B-ephrins, | SH3x3/SH2 | ubiquitous (highest in B) | ||||||||||
| SLAP, SLA (human) | 8q24.2-q24.3 | SH3/SH2 | c-Myc | 5FU,
IL13 |
NK, T, B, APCs |
|||||||||
| SH3 | CIN85, SETA, Ruk, SH3KBP1 (human) | Xp22.1-p21.3 |
|
p85alpha,
CAPZ,
CBL,
Alix,
ALG2, Src>TNFR1 |
SH3x3/cc | Pro-rich | LPS | hhemato. (highest in B) |
mediator for Ub, Ub | |||||
| SLAP130, Fyb (human) | L | 5p13.1 | Fyn, SLP76 | SH3 | TCR/CD3, IL15 | T, NK, APCs |
||||||||
| Bif-1, Endophilin B1, SH3GLB1 (human, mouse) | 1p22 |
|
Bax | cc/SH3 | ubiquitous | |||||||||
| HEF1, CAS-L,NEDD9 (human) | 6p25-p24 |
|
PTK2 | SH3 | ubiquitous (highest in hemato.) |
|||||||||
| STAC (human) | 3p22.3 | C1/SH3 | A-Myb | ubiquitous | ||||||||||
| CMS, CD2AP (human) | L | 6p12 | inhibit |
CD2, CAPZ, nephrin, cortactin, CBL, Rab4, p130CAS | SH3x3/cc | hemato. (highest in preB, DC) |
||||||||
| SHANK1 (human) | 19q13.3 | somatostatin receptor 2 | Ankx6/SH3/PDZ/SAM | ubiquitous | ||||||||||
| HS1,HCLS1 (human) | 3q13 | Lyn, HPK1 | HS1Rx3/SH3 | B, T, NK, APCs |
||||||||||
| EPS8 (human) | 12q23-q24 | SOS1 | PTB/SH3 | E2F | ubiquitous | |||||||||
| PSTPIP1, CD2BP1 (human) | PAPA | 15q24-q25.1 | PTP-PEST, CD2, Pyrin | FCH/cc/SH3 | NK, T, B, APCs |
|||||||||
| ABI2, ABI2B, AIP-1, AblBP3,
SSH3BP2 (human) |
2q33 |
SH3 |
||||||||||||
| GAP | GRAF (human) | 5q31 |
|
FAK |
PH/RhoGAP/SH3 | preB |
||||||||
| AIP1, DAB2IP (human) |
9q33.1-q33.3 |
inhibit |
mediate |
DAB2,
TRAF2 |
C2/RasGAP |
|||||||||
| GEF | Vav1 (human) | L | 19p13.3-p13.2 |
|
|
induce, (-) | SLP76, Shb, Syk, Tyk2, Grb2, ZAP70, , Tec, zyxin, GDI, Siah2, CBL, IKKa | CH/GEF/PH/C1/SH3/SH2/S3 | L | PU.1 | Fyn, CD19, CD22, HHT, LPS, hsp65, androgen | NK, T, B, APCs | casp, Ub | |
| Vav2(human) | 1 | 9q34 |
|
induce | CH/GEF/PH/C1/SH3/SH2/S3 | Ct, LPS | B, bm, preB |
|||||||
| Vav3(human) | 1pter-p21.3 | induce | RhoA, G, PLCg, Shc, PI3Kp85, Grb2 | CH/GEF/PH/C1/SH3/SH2/S3 | ubiquitous (highest in B, NK) |
|||||||||
| NSP3, SH2D3C (human) | 9q34.13 | SH3/GEF | ||||||||||||
| obscurin, OBSCN (human) | 1q42 | titin | IGx53/IQ/IGx4/SH3/GEF/PH/IGx2 | ubiquitous |
||||||||||
| TIAM2 (human) | 6q25 | RBD/PDZ/GEF/PH | LPS | ubiquitous |
||||||||||
| RasGRP1 (human) | 15q15 |
|
RasGEF_N/RasGEF/EF/C1 | hemato, brain |
||||||||||
| Gab | Gab1 (human) | 1 | 4q31.1 | Grb2, SHP2 | PH | ubiquitous |
||||||||
| Gab2 (human) | 11q13.3 | PH | LPS | hemato, brain | ||||||||||
| POSH | POSH, RNF142, SH3RF1, SH3MD2 (human, mouse, D.m.) | 1 | 4q32.3 |
|
|
Rac, MLKs, | SH3/SH3/P-rich/SH3/SH3 | brown fat |
||||||
| ECSIT | ECSIT , SITPEC (human, mouse, D.m.) | 1 | 1,2 | 19pter-19p13.11 |
|
ubiquitous | BMPs | |||||||
| small G |
Rac1(human,), chicken 1B, frog, fly | Xq26.2-27.2 |
|
|
MEKK2-4, POR1, PAKs, PKR2, POSH | G | IRF4 | TGFb, CD3/CD28, HCV, RA, cisplatin, UVA | ubiquitous | |||||
| RhoA(human) | 3p21.3 |
|
|
induce | PKN, PKR2, rhophilin, Rhotekin | G | +PknPRK1 | IRF4, TGFb, HCV, RA | ubiquitous | |||||
| RhoB(human) | 2pter-p12 |
|
|
G | IRF4, HOXD10 | TGFb, LPS, Pa, Ye, c-Myc, TGFR1, AgII, shear stress, IL10 | ubiquitous | |||||||
| RhoC(human) |
|
G | HOXD10 | TGFb, CD3/CD28, LPS, cantharidin | ubiquitous | |||||||||
| CDC42/G25K(human, mouse), S.c. | 1p36.1 |
|
induce | MEKK2-4, CEPs | G | +Wasp, Gdp, Rhogap, etc | estrogen | ubiquitous | ||||||
| RalB (human) | 7p22-p15 | G | TGFR1, ALK1 | ubiquitous | ||||||||||
| GAS6 | GAS6/Axl ligand/AXSF(human) | 13q34 |
|
GLA/EGFx4/(Lamin G) x2 | ubiquitous | Axl substrate, P13K activator | ||||||||
| Protein S, PROS1 (human) | 3p11-q11.2 | CD4BP | GLA/EGFx4/(Lamin G) x2 | ubiquitous | protein C coactivator | |||||||||
| ALG4/ RRP5 | ALG4, RRP5 , Pdcd11 (human , mouse, Ce, Sc, Sp) | 10q23.33 | induce a little | induce | S1 RBD/TPR | TCR | ubiquitous | yeast rRNA synthesis regulator homologue | ||||||
| TTRAP | TTRAP, AD022 (human), mouse, C.e. | 6p22.1-22.3 |
|
TRAFs, CD40, CD30, TNFR2 | CCR4 like TF | hemato. |
||||||||
| SPP1 | SPP1, osteopontin/bone sialoprotein (human, mouse) | 4q21-q25 |
|
|
Osteopontin family | NF-kB | integrin | brain, spinal cord |
||||||
| RING | TRIP(human,mouse, F. rubripes, D.m.) | 3p14.3 |
|
|
TRAF1-2(by cc&LZ), CYLD |
RING/coil-coil/LeuZip | RANKL, UVB, Epo, insulin | ubiquitous | ||||||
| SIVA, CD27BP (human, mouse, -2, -3) | 14q32.33 |
|
CD27, ARG, CVB3 VP2, Bcl2, Bcl-xL | no DD, ZF? | Egr1,
p53,
E2F1 |
TIP30, LPS, Akt., cisplatin, irrad | ubiquitous | |||||||
| OTU |
A20, TNFAIP3 (human, mouse) | L | 1 | 6q21-22 |
|
|
14-3-3, TRAF1, TRAF2, ABINl, ABIN2, LBP1, NEMO, TXBP151 | OTU/ZnF | NF-kB, AP1 | TNFa,
IL1,
TRAIL,
Fas,
CD40,
PMA,
LMP1,
LPS,
MDP,
LTA,
Bm,
Ec,
Hp,
Ld,
Lm,
Mt,
Nc, Pa,
Sa, St,
Tg,
Ye,
flagellin,
MeDNA,
dsRNA,
AdV,
HHV8,
MVA,
BRCA1,
UV,
Cannabinoid,
HHT,
YopP,
EBV,
AmB,
ALA |
hemato. |
deUb | ||
| TRABID, ZRANB1 (human, D.m.) | 1,2 | 10q26.2 |
|
TRAF6 | ZnF/OTU | TNFa | ubiquitous | |||||||
| Cezanne, ZA20D1 (human) | 1 | 1q21.2 |
|
TRAF6 | OTU/ZnF | ErbB4 | ubiquitous | deUb |
||||||
| BCAP | BCAP, PIK3AP1 (human, mouse, rat, chicken ), Dof (Dm) | L | 10q24.2 | Ank/CC | B |
|||||||||
| BANK (human) | 4q24 | Lyn, IP3R | Ank/CC | B |
||||||||||
| GILZ | DIP, GILZ, TSC-22R, DSIPI(human) | Xp21.1-q25 |
|
|
|
Raf-1 | TSC22 | IL2, IL4, DEX, GR, aldosterone, shear stress, ER stress, LiCl, ARNT2 | B, T, NK, APCs |
|||||
| TSC-22,TGFB1I4 (human) | 13q14 |
|
THG-1 | TSC22 | NF-kB, FoxO3 | CD40, Tprim, TGFb, shear stress, FSH, PG, Hp, PMA, GLI1, H-Ras, Rac2, IL15, vesnarinone, La(NO3)3 | ubiquitous (highest in brain) |
|||||||
| THG-1(human) | 7p21-p15 | TSC-22 | TSC22 | brain, spinal cord |
||||||||||
| KIAA0669(human) | 3p13-q26.1 | TSC22 | ubiquitous | |||||||||||
| BST2 |
BST2, DAMP1, GREG (human,
mouse,
rat) |
19p13.2 | induce |
TM/cc | TNFa, IFNa/b | B, NK, T, APCs |
||||||||
| MSP | VAPA (human) |
18p11.22 |
induce |
MSP/cc/TM |
ubiquitous | |||||||||
| VAPB (human) |
20q13 |
ubiquitous | ||||||||||||
| MOSPD2 (human) |
Xp22.31 |
SEC14/MSP/TM |
ubiquitous | |||||||||||
| MOSPD3 (human) |
7q22 |
ubiquitous | ||||||||||||
| TM |
FLJ23091 (human,
mouse,
zebrafish,
Dm,
Ce) |
1p31.2 |
induce |
TMx8 |
ubiquitous (highest in brain, spinal cord) | |||||||||
| NDFIP1 (human) |
5q31.3 |
induce | Nedd4 |
ubiquitous (highest in brain, spinal cord) | ||||||||||
| NDFIP2 (human) |
13q22.2 | brain, spinal cord | ||||||||||||
| HIP14L, HIP3RP, FLJ10852,
ZDHHC13 (human) |
induce | huntingtin |
ANKx6/TMx4/ZnF | ubiquitous | ||||||||||
| filamin |
filamin, FLNA (human) |
Xq28 |
induce | CHx2/filamin x24 |
ubiquitous | |||||||||
| Hsp | Hsp27, HSPB1 (human) | 7q11.23 |
|
ubiquitous | ||||||||||
| HSPB2 (human) | 11q22-q23 | heart, sk. muscle |
-On-line Reviews-
Review of
Adaptor proteins for T cell activation by Koretzky & Myung (Nat Rev Immunol 2001)An Essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 1996 Nov 1;274(5288):782-784
TRAFs by Arch, Gedrich, Thompson (Genes Dev. 1998)
NF-kB activation by Baeuerle & Baltimore (Cell 1996)
IKK by Verma and Jennifer Stevenson (PNAS 1997), by Maniatis (Science 1997), by Stancovski & Baltimore (Cell 1997)
NFkB and Apoptosis Regulators (2) >>See also Caspase Regulator family, Kinases
Review of apoptosis/NFkB by Barinaga (Science 1996)
Links
"A physical map
of the human TNFa/NF-kB signal trunsduction pathway"
Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| HOME | All-in-One Seq Analyzer |
