Regulators

Index

Caspase

CARD/DED/BIR

Bcl-2

TNF/TNFR

Kinases

ILs

Viral

Lipid

Engulf

RING

Toll

Other Apop

Other NFkB

Alphabet

Further impact factors for apoptosis and NF-kB.

(NOTE: This is NOT a main index home page. ).

Wnt pathway and related

Family	Name	specices	apoptosis	NF-kB	KO	structure	3D	locus	upstream regulators	binding factors	memos
WNT	Wnt1	human	inhibit	induce		Wnt		12q12-q13	PEA3, NF-kB, CD9		targets
	Wnt2	human				Wnt		7q31
	Wnt2b, Wnt13	human				Wnt		1p13	Nef, CD9
	Wnt3	human				Wnt		17q21
	Wnt3a, Wnt14	human	related?		L	Wnt		1q42	RA		targets
	Wnt4	human				Wnt		1p36.23-p35.1	A2aR, Pg
	Wnt5a	human				Wnt		3p21-p14	estrogen, LPS, UVB, CD9, IL13
	Wnt5b	human				Wnt		12p13.3	Subst.P
	Wnt6	human				Wnt		2q35
	Wnt7a	human				Wnt		3p25	TNFa, TTF-1, GATA6, Foxa2, Subst.P, estrogen
	Wnt7b	human				Wnt		22q13	TNFa, ARNT2
	Wnt8a	human						5q31
	Wnt8b	human				Wnt		10q24
	Wnt10a	human				Wnt		2q35	Subst.P
	Wnt10b	human				Wnt		12q13
	Wnt11	human				Wnt		11q13.5
	Wnt15, Wnt9b	human				Wnt		17q21
	Wnt16	human				Wnt		7q31
Dickkopf	DKK-1(Dickkopf-1)	human	enhance			DKK		10q11.2	Bmp4, EWS/FLI-1, p53, UV, c-Jun, Ye	LRP5, LRP6, Kremen1, Kremen2	anti-Wnt
	DKK-2	human				DKK		4q25	CREB	LRP5, LRP6,
	DKK-3	human				DKK		11p15.3	EWS/FLI-1
	DKK-4	human				DKK		8p11.2-11.1
LRP	LRP5	human			1	(LDLRbx5/EGF)x4/LDLRax3/TM		11q13.4
	LRP6	human			1	(LDLRbx5/EGF)x4/LDLRax3/TM		12p11-p13		DKK1,DKK2
Kremen	Kremen1	human				kringle/WSC/CUB/TM		22q12.1		DKK
	Kremen2	human				kringle/WSC/CUB/TM		16p13.3		DKK
Frizzled	Fzd1	human	induce			Fz/7TM		7q21	estrogen		anti-Wnt
	Fzd2	human	induce			Fz/7TM		17q21.1	Hoxc8, Wnt-1, RA
	Fzd3	human				Fz/7TM	1	8p21
	Fzd4	human				Fz/7TM		11q14-q21	PTH
	Fzd5	human				Fz/7TM		2q33-q34
	Fzd6	human				Fz/7TM		8q22.3-q23.1
	Fzd7	human				Fz/7TM		2q33	IL10, Stat4b, b-catenin
	Fzd8	human				Fz/7TM	1	10p11.21	AdV
	Fzd9	human				Fz/7TM		7q11.23	Subst.P, LPS
	Fzdz10	human				Fz/7TM		12q24.33
	SARP1, SFRP2	human, mouse	protect			Fz/NTR		4q31.3	estrogen
	SARP2, FRP, SFRP1	human	sensitize			Fz/NTR		8p12-p11.1	DAC/TSA, PRX2
	SFRP3, FRP3, FRZB	human, mouse	related?			Fz/NTR		2qter	PRX2
	SARP3/SFRP5	human	related?			Fz/NTR		10q24.1
	SFRP4/frpHE	human				Fz/NTR		7p14.1
	MFRP	human				TM/CUB/LDLa/CUB/LDLa/Fz		11q23
	carboxypepdase Z, CPZ	human				Fz/carboxypeptidase		4p16.1
armadillo	APC	human, mouse, rat, Xenopus, D.m., Urechis, C.e.(K04G2.8)	inhibit		L	cc/cc/Ser-rich/DE-rich armadillox8/SAMP rpt	L	5q21-q22	c-Myc, p53, USF1, USF2		casp
	APC2, APCL	human, Dm						19p13.3
	beta-catenin	human, mouse, rat, Xenopus, sea urchin,	inhibit?		1	armadillox12	L	3p21	NF-IL6, TGFb, FSH	APC, a-cat., Tcf, Lef	casp,in bcl-2 KO, targets
	gamma-catenin, junction plakoglobin, JUP	human				armadillox11	1	17q21
	delta2-catenin	human				cc/armadillox9		5p15.2		Erbin
	ARVCF	human				cc/armadillox7		22q11		Erbin
	plakophilin	human						2q23-q31
	armadillo	D.m., house fly, spoonworm
RGS	axin 1	human, mouse, rat, chicken	induce			RGS/cc/GSKBD-bBD/dishevelled	L	16p13.3	E2F1	PIASs	SUMO
	axin 2/axil,/conductin	human, mouse, rat				RGS/cc/DAX/dishevelled		17q23-q24	TNFa, TCF, b-cat, estrogen
	RGS1, IER1	human, mouse				RGS		1q31	IL2, PMA
	RGS2	human, mouse				RGS	L	1q31	AIRE, TNFa, PTH, CRF, LPS, Lm, YopP, A2aR, Blimp1	Galpha	accelerate GTPase/inhibit signaling
	RGS3	human, mouse	induce(T)			PDZ/PH/RGS		9q31-q33	IL1, TNFa, IL13
	RGS4	human, mouse, rat	inhibit		1	RGS	L	1q23.1	AP1, Brn3a, HCV		inhibit MAPKs
	RGS5	human, mouse				RGS		1q23.1	PDGF, VEGF, IL1
	RGS6	human, mouse				DEP/GGL/RGS		14q24.3
	RGS7	human, mouse				DEP/GGL/RGS		1q43
	RGS8	human, mouse, rat				RGS		1q25
	RGS9	human, mouse			1	GGL/RGS	L	17q23-q24
	RGS10	human, mouse				GGL		10q25	Brn3a, ARNT2
	RGS11	human				DEP/GGL/RGS		16p13.3
	RGS12	human				PDZ/PTB/RGS/RBDx2/GoLoco		4p16.3	Cdx2
	RGS13	human, mouse				RGS		1q25.3
	RGS14	human						5q35.3	TNFa
	RGS16	human				RGS		1q25-q31	NF-kB, TNFa, IKKs, LPS, IL10
	RGS17	human				RGS		6q25-q26
	RGS18	human				RGS		1q31.2
	RGS19, GAIP	human				RGS		20q13.3
	RGS20, RGSZ1	human				RGS		8q12.1
	other RGS	F16H9.1(C.e.) etc								Dishevelled
NKD	naked cuticle, NKD1	human, Dm				EF		16q12	Wingless
Dishevelled	Dishevelled 1, DVL1	human, rat,Dm., Xl, Ce (yk10b11.5, yk35a4.5, yk134c11.5, T05C12.6)	induce			N domain/DHR	L	1p36	Ld	MusK, Nkd, mtSOD1, NEDL1	Ub
	Dishevelled 2, DVL2	human, mouse, Xl,					1	17p13.2
	Dishevelled 3, DVL3	human, mouse, zebrafish,						3q27
DAAM1	DAAM1	human				cc/FH2		14q22.3	FKHR
	DAAM2	human				cc/FH2		6p21.1
	diaphanous 1, DIAPH1	human				M/cc/FH2		5q31
GSK	GSKbeta3	see kinases
LEF-TCF	LEF-TCF	see TFs
CCN	WISP1	human	protect			IB/VWC/TSP1/CT		8q24.1-q24.3	CREB, Wnt1, b-catenin, CD9		binds to decorin, biglycan
	WISP2	human				IB/VWC/TSP1		20q12-q13.1	Wnt1
	WISP3	human				IB/VWC/TSP1/CT		6q22-q23	CD9
	CTGF	human				IB/VWC/TSP1/CT		6q23.1	SCF, TGFb, TNFa, CSBG, IL1, BMPs, FKHR, Akt, DIM, WT1, Egr1, Lm, Pg Ye , MVA
	NOV	human				IB/VWC/TSP1/CT		8q24.1

Review of Wnt signaling by Polakis (Genes Dev. 2000), Peifer & Polakis (Science 2000), van de Wetering et al. (Cell 2002)

Microarray of APC by Lin et al. (Cancer Res. 2001)
Microarray of RA & Wnt-1 by Tice et al. (J. Biol. Chem. 2002)

SMAD

Protein Species apoptosis NF-kB JNK locus binding partner KO upstream regulators 3D memo

SMAD1(MADR1,Xmad), MAD(Dm),Sma, MADH1 human,mouse, rat, X.laevis, MAD(D.m.,), C.e. (Sma2 in ZK370/pAR2, Sma3 in R13F6)

4q28 SMAD4, Tob, ERa, Smurf2
ALK1, ribavirin, TNFa
1 BMP .

SMAD2 (MADR2, MAD2, JV18-1) human,mouse,rat,X.laevis stimulate

18q21.1 SMAD4, Hgs, p53, Ski L estrogen 1 TGFb/Activin

SMAD3 (MAD3, jv15-2) human, mouse, rat enhance

15q21-q22 SMAD4, Ski, GATA3, YB1, Akt, PIASy L ARNT2, hypoxia, UV, Ye L TGFb/Activin

SMAD4 (Dpc4, Medea) human,mouse,rat, Medea (D.m.), Sma4 in R12B2, DAF-3 (C.e.) in F25E2 induce

18q21.1 Ski,SMIF, Dok1, PIASy L FKHR, Smad2; DAXX

Sumo, Ub

SMAD5 human, mouse, rat (inhibit)/mediate

5q31 Tob L IL1, TEL, phencyclidine, Hp(cagPAI)
angiogenesis, BMP

SMAD6 human, mouse,X.laevis(truncated) inhibit

15q21-q22

ALK1, Egr1, BMPs, TGFb, Pg

antagonize
TGFb/Activin/BMP

SMAD7 human,mouse,X.laevis induce/inhibit inhibit induce 18q21.1 p38, PIASy, WWP1

p53, Smad3/4 , Ski,TGFb, Sp1, AP1, endostatin, Sp, HHV8, ALK1, Gab2

antagonize
TGFb/Activin/BMP

SMAD8 X.laevis

BMP

SMAD9 human

13q12-q14

DAD D.m.

F01G10.8,F37D6.7,R05D11,, C.elegans

SKI (human)

1q22-q24
SMAD3/4, HIPK2
L
; Cdc34
1

Sno (human)

3q26

TGFb

Review (non-online) by Heldin et al. (Nature 1997)
Review (non-online) by Derynck et al. (Cell 1998)
Review of Ski/Sno by Luo K (Curr Opin Genet Dev. 2004)

TGF beta family

Protein Species apoptosis NF-kB JNK KO Locus Upstream regulators Memo

TGFb1 human, mouse, Ce(Dbl1) induce/(inhibit) inhibit/(induce) induce L 19q13.2 EGR1, AP1, WT1, c-Myc, N-Myc, Sp1, RARa, RXRa, RA, VDR, EWS/FLI-1, TNFa, Fas, TRAIL, CD28/PMA, LPS, MDP, b-glucan, Pg, Py, Sm, ECM, PTH, NGF, insulin, GM-CSF, UVB, EP4, D3, Ha-Ras,E1A,HBx, IE2, E6(HPV16), LMP1, tat, Nef, apoptotic cells, PTEN, PMA, AgII, EP4, DIM, I3C targets, inflammation. fibronectin,PDGF-B, IL2

TGFb2 human, mouse induce/inhibit

1q41 Rb, c-Myc, USFs, AP1/ATF2, CREB, ATF1, PRX2, LPS, Hf, Ma, Sp, St, TSH, CSV-B3, LMP1, PAX3-FKHR, ER, GR, genistein, DIM, I3C

TGFb3 human,mouse induce/inhibit
induce L 14q24 Sp1, c-Myc, methylation, SCF, Stat4, Nur77, D3
2nd palate fusion, lung

GDF1 human, mouse

1 19p12

GDF2, BMP9 human

10q11.21

GDF3 human, mouse

12p13.1

GDF5/LAP4/CDMP1 human, mouse

(-) L 20q11.2
LPS binding

GDF6 mouse

GDF7 mouse

GDF8, myostatin human, mouse

L 2q32.2 Nef, CD28, VDR, Brn3b

GDF9 human, mouse need?

L 5q31.1 GCNF ovarian folliculogenesis

GDF9B, BMP15 human

Xp11.2 GCNF

GDF10, BMP3B human, mouse

10q11.21 IFNs, IL1, H-Ras

GDF11, BMP11 human

1 12q13.13

Inhibin alpha human

L 2q33-q36 hypoxia, b-glucan

Activin/Inhibin beta A human, mouse induce

1 7p15-p13 LPS, BLP, N-Myc, IGF1, TNFa, Sd, TPA, hypoxia, OX-CA

Activin/Inhibin beta B human, mouse

L 2cen-q13

Activin/Inhibin beta C human, mouse

1

Protein	Species	apoptosis	NF-kB	JNK	locus	binding partner	KO	upstream regulators	3D	memo
SMAD1(MADR1,Xmad), MAD(Dm),Sma, MADH1	human,mouse, rat, X.laevis, MAD(D.m.,), C.e. (Sma2 in ZK370/pAR2, Sma3 in R13F6)				4q28	SMAD4, Tob, ERa, Smurf2		ALK1, ribavirin, TNFa	1	BMP .
SMAD2 (MADR2, MAD2, JV18-1)	human,mouse,rat,X.laevis	stimulate			18q21.1	SMAD4, Hgs, p53, Ski	L	estrogen	1	TGFb/Activin
SMAD3 (MAD3, jv15-2)	human, mouse, rat	enhance			15q21-q22	SMAD4, Ski, GATA3, YB1, Akt, PIASy	L	ARNT2, hypoxia, UV, Ye	L	TGFb/Activin
SMAD4 (Dpc4, Medea)	human,mouse,rat, Medea (D.m.), Sma4 in R12B2, DAF-3 (C.e.) in F25E2	induce			18q21.1	Ski,SMIF, Dok1, PIASy	L	FKHR, Smad2; DAXX		Sumo, Ub
SMAD5	human, mouse, rat	(inhibit)/mediate			5q31	Tob	L	IL1, TEL, phencyclidine, Hp(cagPAI)		angiogenesis, BMP
SMAD6	human, mouse,X.laevis(truncated)	inhibit			15q21-q22			ALK1, Egr1, BMPs, TGFb, Pg		antagonize TGFb/Activin/BMP
SMAD7	human,mouse,X.laevis	induce/inhibit	inhibit	induce	18q21.1	p38, PIASy, WWP1		p53, Smad3/4 , Ski,TGFb, Sp1, AP1, endostatin, Sp, HHV8, ALK1, Gab2		antagonize TGFb/Activin/BMP
SMAD8	X.laevis									BMP
SMAD9	human				13q12-q14
DAD	D.m.
F01G10.8,F37D6.7,R05D11,,	C.elegans
SKI (human)					1q22-q24	SMAD3/4, HIPK2	L	; Cdc34	1
Sno (human)					3q26					TGFb