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Publications

Recent publications

  1. A. Mansour, L.P. Taylor, J.L. Fine, R.C. Thompson, M.T. Hoversten, H.I. Mosberg, S.J. Watson,  and H. Akil. Key residues defining the opioid receptor binding pocket: a site-directed mutagenesis study J. Neurochem., 68:344-353, 1997. Abstract.
  2. Lomize A.L. and Mosberg H.I. Thermodynamic model of secondary structure for a-helical peptides and proteins. Biopolymers. 42(2):239-269, 1997. Abstract.
  3. Pogozheva I.D., Lomize A.L. and Mosberg H.I. The transmembrane 7-a-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints. Biophysical Journal. 72(5):1963-1985, 1997. Abstract.
  4. Mosberg H.I., Dua R.K., Pogozheva I.D. and Lomize A.L. Development of a model for the d-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain. Biopolymers. 39(3):287-296, 1996. Abstract.
  5. Lomize A.L., Pogozheva I.D. and Mosberg H.I. Development of a model for the d-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH with other conformationally constrained delta-receptor selective ligands.Biopolymers. 38(2):221-234, 1996. Abstract.
  6. Lomize A.L. and Mosberg H.I. Thermodynamic model of a-helix in aqueous solution and micelle-bound state. in Peptides: Chemistry, Structure, and Biology, Proceedings of the 14th American Peptide Symposium, P. Kaumaya and R.S. Hodges, Eds., Mayflower Scientific, England, pp. 474-476, 1996. Abstract.
  7. Pogozheva I.D., Lomize A.L., and Mosberg H. I. Modeling of the d-opioid receptor transmembrane a-bundle, in Peptides: Chemistry, Structure, and Biology, Proceedings of the 14th American Peptide Symposium, P. Kaumaya and R.S. Hodges, Eds., Mayflower Scientific, England, pp.350-351.1996. Abstract.
  8. Wang C. and Mosberg H.I. Synthesis of a novel series of topographically constrained amino acids: benzo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids.Tetrahedron Lett., 36:3623-3626, 1995. Abstract.
  9. Mosberg H.I., Omnaas J.R., Lomize A.L., Heyl D.L., Nordan I., Mousigian C., Davis P. and Porreca F. Development of a model for the d-opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry. 37(25): 4384-4391, 1994. Abstract.
  10. Mosberg H.I., Lomize A.L., Wang C., Kroona H., Heyl D.L., Sobczyk-Kojiro K., Ma W., Mousigian C. and Porreca F. Development of a model for the d-opioid receptor pharmacophore. 1. Conformationally restricted Tyr1replacements in the cyclic d receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry. 37(25):4371-4383, 1994. Abstract.
  11. Lomize A.L., Flippen-Anderson J.L, George C., and Mosberg H.I. Conformational analysis of the d receptor-selective, cyclic opioid peptide, Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Comparison of X-ray crystallographic structures, molecular mechanics simulations and 1H NMR data. J. Amer. Chem. Soc., 116:429-436, 1994. Abstract.
  12. Mosberg H.I., Omnaas J.R., Sobczyk-Kojiro K., Ho J.C., Ma W., Bush P., Mousigian C., and Lomize A.L. Pharmacophore elements of the TIPP (Tyr-Tic-Phe-Phe) class of d-opioid receptor antagonists, Letters in Peptide Science, 1:69-72, 1994. Abstract.
  13. Lomize A.L. and Mosberg H.I. A conformational modelling of the d-receptor bound conformation that is similar for the cyclic opioid tetrapeptides and d selective alkaloids, in Peptides: Chemistry, Structure and Biology, Proceedings of the 13th American Peptide Symposium, R.S. Hodges and J.A. Smith, Eds., ESCOM. Leiden, pp 905-907.1994.Abstract.
  14. Mosberg H.I., Kroona H.B., Omnaas J.R., Sobczyk-Kojiro K., Bush P., and Mousigian C. Cyclic deltorphin analogues with high d opioid receptor affinity and selectivity. in Peptides: Chemistry, Structure and Biology, Proceedings of the 13th American Peptide Symposium, R.S. Hodges and J.A. Smith, Eds., ESCOM. Leiden, pp 514-516.1994. Abstract.

In press or submitted.

  1. Fowler C.B., LeVine H., and Mosberg H.I. Examination of the role of TMH VII in subtype-selective ligand binding using semi-synthetic muscarinic receptors in Peptides: Chemistry, Structure, and Biology, Proceedings of the 15th American Peptide Symposium, in press 1998. Abstract.
  2. Ho J.C., Mousigian C.A., Mosberg H.I. Elucidation of the conformational features within a series of tetrapeptides which determine the selective recognition of m versus d opioid receptors. in Peptides: Chemistry, Structure, and Biology, Proceedings of the 15th American Peptide Symposium, in press 1998. Abstract.
  3. Gregson K.S., Marletta M.A. and Mosberg H.I. Inhibition of nitric oxide synthase with calmodulin binding peptides. in Peptides: Chemistry, Structure, and Biology, Proceedings of the 15th American Peptide Symposium, in press, 1998. Abstract.
  4. Pogozheva I.D., Lomize A.L. and Mosberg H.I. The origin of specificity in the opioid receptor family. Peptides: Chemistry, Structure, and Biology, Proceedings of the 15th American Peptide Symposium, in press 1998. Abstract.
  5. Pogozheva I.D., Lomize A.L. and Mosberg H.I. Opioid receptor 3D structures from distance geometry calculations with hydrogen bonding constraints.Biophysical Journal submitted 1998. Abstract.
  6. Lomize A.L, Pogozheva I.D. and Mosberg H.I. Structural organization of G protein-coupled receptors.Perspectives in Drug Discovery and Design, in press, 1998. Abstract.

Other publications.

  1. Mosberg H.I. and Kroona H.B. Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity. Journal of Medicinal Chemistry. 35(23):4498-4500, 1992 Nov 13. Abstract.
  2. Heyl D.L. and Mosberg H.I. Modification of the Phe3 aromatic moiety in d -receptor-selective dermorphin/deltorphin-related tetrapeptides. Effects on opioid receptor binding. International Journal of Peptide and Protein Research.39(5):450-457, 1992 May. Abstract.
  3. Heyl D.L.and Mosberg H.I. Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity. Journal of Medicinal Chemistry. 35(9):1535-1541, 1992 May 1. Abstract.
  4. Heyl D.L., Omnaas J.R., Sobczyk-Kojiro K., Medzihradsky F., Smith C.B. and Mosberg HI. Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide.International Journal of Peptide and Protein Research. 37(3):224-229, 1991 Mar. Abstract.
  5. Mosberg H.I., Heyl D.L., Haaseth R.C., Omnaas J.R., Medzihradsky F. and Smith C.B. Cyclic dermorphin-like tetrapeptides with d-opioid receptor selectivity. 3. Effect of residue 3 modification on in vitro opioid activity.Molecular Pharmacology. 38(6):924-928, 1990 Dec. Abstract.
  6. Haaseth R.C., Sobczyk-Kojiro K., Medzihradsky F., Smith C.B. and Mosberg H.I. Single residue modifications of the d opioid receptor selective peptide, [D-Pen2,D-Pen5]-enkephalin (DPDPE). Correlation of pharmacological effects with structural and conformational features. International Journal of Peptide and Protein Research. 36(2):139-146, 1990 Aug. Abstract.
  7. Mosberg H.I., Omnaas J.R., Medzihradsky F. and Smith C.B. I Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high d opioid receptor selectivity and affinity. Life Sciences. 43(12):1013-20, 1988. Abstract.
  8. Mosberg H.I., Haaseth R.C., Ramalingam K., Mansour A., Akil H. and Woodard R.W. Role of steric interactions in the d-opioid receptor selectivity of [D-Pen2, D-Pen5]enkephalin. International Journal of Peptide and Protein Research. 32(1):1-8, 1988 Jul. Abstract.
  9. Mosberg H.I., Omnaas J.R. and Goldstein A. Structural requirements for d opioid receptor binding. Molecular Pharmacology. 31(6):599-602, 1987 Jun. Abstract.
  10. Mosberg H.I. 1H-n.m.r. investigation of conformational features of cyclic, penicillamine-containing enkephalin analogs. International Journal of Peptide and Protein Research. 29(2):282-288, 1987. Abstract.

This page was last updated 05/01/98  by I. D. Pogozheva.