Research Interests/Projects

	Knowledge-based drug design
	Peptide synthesis
	HPLC

Finger information

1. Mosberg H.I., Omnaas J.R., Lomize A.L., Heyl D.L., Nordan I., Mousigian C., Davis P. and Porreca F. Development of a model for the d-opioid receptor pharmacophore. 2. Conformationally restricted Phe³ replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry.37(25):4384-4391, 1994 Dec 9. Abstract.
2. Mosberg H.I., Omnaas J.R., Sobczyk-Kojiro K., Ho J.C., Ma W., Bush P., Mousigian C., and Lomize A.L. Pharmacophore elements of the TIPP (Tyr-Tic-Phe-Phe) class of d-opioid receptor antagonists, Letters in Peptide Science, 1:69-72, 1994. Abstract.
3. Mosberg H.I., Kroona H.B., Omnaas J.R., Sobczyk-Kojiro K., Bush P., and Mousigian C. Cyclic deltorphin analogues with high d opioid receptor affinity and selectivity. in Peptides: Chemistry, Structure and Biology, Proceedings of the 13^th American Peptide Symposium, R.S. Hodges and J.A. Smith, Eds., ESCOM. Leiden, pp 514-516.1994. Abstract.
4. Heyl D.L., Omnaas J.R., Sobczyk-Kojiro K., Medzihradsky F., Smith C.B. and Mosberg HI. Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide.International Journal of Peptide and Protein Research. 37(3):224-229, 1991 Mar. Abstract.
5. Mosberg H.I., Heyl D.L., Haaseth R.C., Omnaas J.R., Medzihradsky F. and Smith C.B. Cyclic dermorphin-like tetrapeptides with d-opioid receptor selectivity. 3. Effect of residue 3 modification on in vitro opioid activity.Molecular Pharmacology. 38(6):924-928, 1990 Dec. Abstract.
6. Mosberg H.I., Omnaas J.R., Medzihradsky F. and Smith C.B. I Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high d opioid receptor selectivity and affinity. Life Sciences. 43(12):1013-20, 1988. Abstract.
7. Mosberg H.I., Omnaas J.R. and Goldstein A. Structural requirements for d opioid receptor binding. Molecular Pharmacology. 31(6):599-602, 1987 Jun. Abstract.