Home Address: 993 Fountain St.
                               Ann Arbor, MI 48103
                               Telephone: (313) 996-4068

Work Addresses: Parke-Davis Pharmaceutical Research
                                Ann Arbor, MI 48105
                                Telephone: (734) 422-5614

                                Department of Medicinal Chemistry
                               College of Pharmacy, University of Michigan
                               Ann Arbor, MI 48109
                               Telephone: (734) 764-7338

E-mail: cbfowler@umich.edu

Marital Status: Married to David Evers, no children.

Date of Birth: May 16, 1972

To examine the structure and function of the human Muscarinic receptors subtypes 1 and 2 (hm1 and hm2) by reconstituting a cloned and expressed truncated receptor (containing transmembrane helices I-VI) with a synthetically prepared transmembrane helix VII. Incorporation of unnatural amino acids and extrinsic fluorophores into the synthetic peptide will provide probes not available with molecular biological techniques.

    1994 - Present Graduate Student, Department of Medicinal Chemistry
University of Michigan
Ann Arbor, MI 48109
    Thesis Advisors:
Dr. Henry I. Mosberg, Professor, Dept. of Medicinal Chemistry
Dr. Harry LeVine, Associate Research Fellow, Parke-Davis Pharmaceutical Research
    1990-1994 B. S., Chemistry  Erskine College  Due West, SC 29639
                        Senior Thesis Research: "Synthesis of Sinefungin"
                        Advisor: Dr. Warren Beach, University of Georgia

 RESEARCH EXPERIENCE:

1992-1994    Undergraduate Research Project: "Synthesis of Cyclic Imines"
                    Erskine College, Due West, SC
                    Advisor: Dr. Douglas F. Fry

1993   Summer Undergraduate Research Program: "Synthesis of Sinefungin"
                   Department of Medicinal Chemistry, University of Georgia, Athens, GA
                   Advisor: Dr. Warren Beach

1990   Summer Research Program "Characterization of Volatiles in Fescue"
                   Richard B. Russell Agricultural Research Center, Athens, GA

 PUBLICATIONS:

Journal Articles :

Douglas F. Fry, Carol B. Fowler, R. Karl Dieter. Synthesis of Cyclic Imines by Addition of Grignard Reagents to w-Bromonitriles. Synlett, 10: 836-838 (1994).

Proceedings Volumes:

Carol B. Fowler, Harry LeVine, Henry I. Mosberg. Examination of the Role of TMH-VII in Subtype-Selective Ligand Binding Using Semi-Synthetic Muscarinic Receptors. Peptides: Chemistry, Structure and Biology, Proceedings of the 15th American Peptide Symposium (in press).

Presentations:

1. Carol B. Fowler, Douglas F. Fry, R. Karl Dieter. Synthesis of Cyclic Imines by Addition of Grignard Reagents to w-Bromonitriles. 1993 South-East Regional Student ACS Meeting.

2. Carol B. Fowler, Harry, LeVine, Henry I. Mosberg. Examination of the Role of TMH-VII in Subtype-selective Ligand Binding Using Semi-synthetic Receptors. 15th American Peptide Symposium. June 14-19, 1997.