RESULTS: A total of 436 patients underwent the Wada procedure between April 1991 and June 2013, and 431 patients were included in the final analysis. Twenty-five (5.8%) patients had notable clinical events and eight (1.9%) had clinical events meeting criteria for complication, which included seizures, status epilepticus, internal carotid artery vasospasm, inadvertent injection of anesthetic in the external carotid artery, and transient encephalopathy. No complications were associated with significant morbidity or mortality.
CONCLUSION: This retrospective review of patients undergoing the Wada test found significantly fewer associated complications in comparison to previously published studies, with no patients experiencing long-term morbidity. The Wada test should be considered a safe diagnostic tool for lateralizing language and memory.