Department of Statistics
439 West Hall, 1085 South University Ave., Ann Arbor, MI 48109-1107
Phone: 734.763.3519Fax: 734.763.4676
Title: A statistical decision procedure for personalizing treatment
In personalized treatment the recommended treatment is based on patient characteristics. Given pre-specified subgroups, we define the subgroup indicator as useful in personalized decision making if for particular subgroups there is sufficient evidence to recommend one treatment, while for other subgroups, either there is sufficient evidence to recommend a different treatment, or there is insufficient evidence to recommend a particular treatment. We propose a two-stage statistical decision procedure to evaluate if a subgroup indicator is useful in personalized decision making. In the first stage of the procedure, we utilize the test statistic for testing treatment-subgroup interaction. If the first stage test statistic exceeds the critical value, we proceed to the second stage of the procedure and utilize test statistics for testing subgroup treatment effects. We control a generalized Type I error rate. We illustrate the proposed procedure using data from Child/Adolescent Anxiety Multimodal Study (CAMS).
For questions regarding the Statistics Student Seminar or if you are interested in presenting, please contact Joonha Park (joonhap@umich.edu) or Jun Guo (guojun@umich.edu).