Intracellular Small Molecule Transport 

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 Efficacy and toxicity are the two key parameters that measure how a drug 'works'.  These two parameters characterize a drugs therapeutic index: the dose range in which a drug is active without exerting side effects.   While many small molecules and drugs are sequestered in intracellular compartments, little is known about how such sequestration influences drug absorption, distribution, metabolism, elimination and toxicology, with their consequent effects on efficacy and toxicity. 

 To increase efficacy and reduce toxicity, one aim of our research is to develop means to control the subcellular distribution of small molecules. For this purpose, we have developed combinatorial libraries of fluorescent molecules to study how chemical structure influences subcellular localization. We have also pioneered the application of statistical techniques for quantitative structure-localization relationship (QSLR) studies. Pictures such as the ones shown below are microscopic images of cells labeled with fluorescent small molecule trackers of subcellular transport.

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  © 2003 Gustavo R. Rosania.