Mohammad Fallahi Sichani, Ph.D.

Postdoctoral Fellow
Systems Biology
Harvard Medical School

Harvard Medical School
Department of Systems Biology
Sorger Lab
200 Longwood Ave., Boston, MA 02115
Tel: (617) 432-6907
Email:
fallahi [AT] umich.edu
mohammad_fallahisichani [AT] hms.harvard.edu



Research Interests:


Multi-Scale Analysis of Biological Systems (Modeling and Experiments)
Receptor Dynamics, Cell Signaling Systems Biology, Systems Immunology and Pharmacology
Mathematical Modeling of Biological Processes
Systems Biology of Infectious, Inflammatory Disease and Cancer
Cellular and Tissue Engineering, Regenerative Medicine

Education:

(2012-Present): Postdoctoral Research Fellow in Systems Biology (Harvard Medical School)
- Advisor : Prof. Peter Sorger

(2011): Ph.D. in Chemical Engineering (University of Michigan)
University of Michigan College of Engineering 2011 Outstanding Ph.D. Research Award
- Advisor : Prof. Jennifer J. Linderman
- Co-Mentor : Prof. Denise E. Kirschner

(2009): M.Sc. in Chemical Engineering (University of Michigan)

(2007): Integrated B.Sc. and M.Sc. in Biotechnology (Bioprocess Engineering) (University of Tehran)

Curriculum Vitae:


Research Group:


Previous Research Groups:



Previous Collaborations:



Honors and Awards:


(2011): Richard and Eleanor Towner Prize for Outstanding PhD Research Award, College of Engineering, University of Michigan
(2011): Graduate Teaching Fellow of Chemical Engineering, University of Michigan
(2011): Travel Fellowship, 5th Annual q-Bio Conference in Cellular Information Processing
(2011): Rackham Predoctoral Fellowship, University of Michigan
(2010): PhD student department seminar speaker, Department of Chemical Engineering, University of Michigan
(2010): Best Poster Award in the 2010 Donald L. Katz Lectureship Poster Competition, Department of Chemical Engineering, University of Michigan
(2010): University of Michigan Chapter of Phi Kappa Phi 2010 Graduate Award
(2009): Best Poster Award in the Systems Biology Symposium 2009, University of Michigan
(2009): Rackham International Student Fellowship
(2009-Present): member of the Honor Society of Phi Kappa Phi
(2003-07): Iranian Ministry of Science, Research and Technology Fellowship
(2001): Ranked 1st in the nation-wide entrance exam for Iranian universities among 450,000 participants:
Received awards for distinction from:
- The Presidential Office, Tehran, Iran
- The Ministry of Science, Research and Technology, Tehran, Iran
- The President of the University of Tehran, Tehran, Iran

Journal Papers:

Fallahi-Sichani M, Kirschner DE, Linderman JJ. The dynamics of TNF-mediated NF-kappaB signaling control tuberculosis granuloma formation and function, (submitted).


Kirschner DE, Fallahi-Sichani M, Marino S, Linderman JJ. Tunable resolution as a tool to study multi-scale, multi-organ models in systems biology: Applications to infection with Mycobacterium tuberculosis and HIV-1, (in preparation).


Fallahi-Sichani M, Flynn JL, Linderman JJ, Kirschner DE. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability. J Immunol. (in press)

Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multiscale computational modeling reveals a critical role for TNF-alpha receptor 1 dynamics in tuberculosis granuloma formation. J Immunol. 2011;186(6):3472-83.


Fallahi-Sichani M, Schaller MA, Kirschner DE, Kunkel SL, Linderman JJ. Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma. PLoS Comput Biol. 2010;6(5):e1000778.

Fallahi-Sichani M, Linderman JJ. Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: A computational study. PLoS One. 2009;4(8):e6604.

Fallahi-Sichani M, Soleimani M, Najafi SM, Kiani J, Arefian E, Atashi A. In vitro differentiation of cord blood unrestricted somatic stem cells expressing dopamine-associated genes into neuron-like cells. Cell Biol Int. 2007;31(3):299-303.

Mohammadi Y, Soleimani M, Fallahi-Sichani M, Gazme A, Haddadi-Asl V, Arefian E, Kiani J, Moradi R, Atashi A, Ahmadbeigi N. Nanofibrous poly(epsilon-caprolactone)/poly(vinyl alcohol)/chitosan hybrid scaffolds for bone tissue engineering using mesenchymal stem cells. Int J Artif Organs. 2007;30(3):204-11.

Book Chapters:

Fallahi-Sichani M, Marino S, Flynn JL, Linderman JJ, Kirschner DE. A systems biology approach for understanding granuloma formation and function in tuberculosis, In McFadden J, Beste D, Kierzek A (Ed.), Systems biology of tuberculosis. Springer, (in press)

Marino S, Fallahi-Sichani M, Linderman JJ, Kirschner DE. Mathematical models of anti-TNF therapies and their correlation with tuberculosis, In Pathak Y, Benita S (Ed.), Antibody-mediated drug delivery systems: Concepts, Technology and Applications. John Wiley and Sons, (in press)

Conferences & Talks:

TALKS AND CONFERENCE ORAL PRESENTATIONS:

Fallahi-Sichani M, Kirschner DE, Linderman JJ. A systems biology approach to identify immune targets that control tuberculosis granuloma function. AIChE (American Institute of Chemical Engineers) Annual Meeting 2011, Minneapolis, MN, USA.

Fallahi-Sichani M, Kirschner DE, Linderman JJ. The dynamics of TNF signaling control tuberculosis granuloma formation. The 5th Annual q-bio Conference on Cellular Information Processing, August 2011, Santa Fe, NM, USA.

Multi-scale analysis of TNF-regulated immune response to Mycobacterium tuberculosis infection. Mathematical Biology Seminar, Department of Mathematics, The University of British Columbia, March 2011, Vancouver, BC, Canada. (Invited)

Multi-scale computational modeling reveals a critical role for TNF receptor dynamics in tuberculosis granuloma formation. The University of Michigan Department of Chemical Engineering Seminar Series, November 2010, Ann Arbor, MI, USA. (Invited)

Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Experimental and mathematical approaches to multi-scale analysis of tumor necrosis factor-regulated immune response to tuberculosis. AIChE (American Institute of Chemical Engineers) Annual Meeting 2010, Salt Lake City, UT, USA.

Harris LA, Hogg JS, Fallahi-Sichani M, Linderman JJ, Kirschner DE, Faeder JR. A novel computational architecture for construction and execution of modular, multi-scale, multi-algorithm dynamical models. AIChE (American Institute of Chemical Engineers) Annual Meeting 2010, Salt Lake City, UT, USA.

Fallahi-Sichani M, Schaller MA, Kirschner DE, Kunkel SL, Linderman JJ. Model-based analysis and quantitative measurement of key components of tumor necrosis factor trafficking in a tuberculosis granuloma. AIChE (American Institute of Chemical Engineers) Annual Meeting 2009, Nashville, TN, USA.

Fallahi-Sichani M, Linderman JJ. Regulation of G-protein signaling by receptor organization: the role of dimerization and lipid rafts. BMES (Biomedical Engineering Society) Annual Fall Meeting 2008, St. Louis, MO, USA.

CONFERENCE POSTER PRESENTATIONS:

Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multi-scale modeling of tumor necrosis factor-regulated granuloma formation in tuberculosis. BMES (Biomedical Engineering Society) Annual Fall Meeting 2010, Austin, TX, USA.

Fallahi-Sichani M, Schaller MA, Kirschner DE, Kunkel SL, Linderman JJ. Toward a multi-scale model of tumor necrosis factor regulated immune response to tuberculosis. Systems Biology Symposium 2009, Ann Arbor, MI, USA. *BEST POSTER PRIZE WINNER*

Fallahi-Sichani M, Schaller MA, Kunkel SL, Linderman JJ. Quantification of processes that control tumor necrosis factor availability in a tuberculosis granuloma. The CMPI Symposium on Multi-Scale Modeling of Host/Pathogen Interactions 2009, Pittsburgh, PA, USA.

Fallahi-Sichani M, Linderman JJ. Quantifying factors that control tumor necrosis factor availability in a tuberculosis granuloma. Midwest Biomedical Engineering Conference (MBEC) 2009, Ann Arbor, MI, USA.

Fallahi-Sichani M, Soleimani M, Atashi A, Ahmadbeigy N, Fazel E. Differentiation of human mesenchymal stem cells into dopaminergic neuron-like cells in vitro: increasing hope to Parkinson's disease cell therapy. 5th International Congress of Medical Sciences 2006, Sofia, Bulgaria.

Fallahi-Sichani M, Seyed-Jaafari E, Semsarha F, Moosavi-Movahedi A.A. Catalytic activity for hematin in sodium dodecyl sulfate reverse micelles as a catalase model. International Biocatalysis Conference 2005, St.Petersburg, Russia.

Fallahi-Sichani M, Seyed-Jaafari E, Semsarha F, Moosavi-Movahedi A.A. Location of hematin in sodium dodecyl sulfate reverse micelles as a hemoenzyme model. 1st National Student Conference of Biotechnology 2005, Tehran, Iran.