Welcome to the Engel Lab

Relevant Publications:

  1. McGhee, J.D. and J.D. Engel (1975) Subunit structure of chromatin is the same in plants and animals, Nature 254, 449-50.
  2. Dodgson, J.B., Strommer, J. and J.D. Engel (1979) Isolation of the chicken β-globin gene and a linked embryonic gene from a chicken DNA recombinant library, Cell 17, 879-87.
  3. Stalder, J., Groudine, M., Dodgson, J.B., Engel, J.D. and H. Weintraub (1980) Hb switching in chickens, Cell 19, 973-80.
  4. Stalder, J., Larsen, A., Groudine, M., Dolan, M., Engel, J.D. and H. Weintraub (1980) Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNase I, Cell 20, 451-60.
  5. Dolan, M., Sugarman, B.J., Dodgson, J.B. and J.D. Engel (1981) Chromosomal arrangement of the chicken β-type globin genes, Cell 24, 669-677.
  6. Choi, O.-R. and J.D. Engel (1986) A 3' enhancer is required for temporal and tissue-specific transcriptional activation of the chicken β-globin gene, Nature 323, 731-34.
  7. Choi, O.-R. B. and J.D. Engel (1988) Developmental regulation of β-globin gene switching, Cell 55, 17-26.
  8. Yamamoto, M., Ko, L.J., Leonard, M.W., Beug, H., Orkin, S.H. and J.D. Engel (1990) Activity and expression of the NF-E1 [GATA] multigene family, Genes Dev. 4, 1650-1662.
  9. Lim, K.-C., Briegel, K., Plank, C., Beug, H., Engel, J. D. and M. Zenke (1993) Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroblast differentiation in a hormone-dependent manner, Genes Dev. 7, 1097-1109.
  10. Pandolfi, P.P., Roth, M.E., Karis, A., Leonard, M.W., Dzierzak, E., Grosveld, F., Engel, J. D., and M. H. Lindenbaum (1995) Targeted disruption of the Gata3 gene causes severe abnormalities in the nervous system and fetal liver haematopoiesis, Nature Gen. 11, 40-4.
  11. Bungert, J., Davé, U., Lim, K.-C., Lieuw, K. H., Shavit, J. A., Liu, Q. and J. D. Engel (1995) Synergistic regulation of human β-globin gene switching by locus control region elements HS3 and HS4, Genes Dev. 9, 3083-96.
  12. Shavit, J., Motohashi, H., Onodera, K., Yamamoto, M. and J.D. Engel (1998) Impaired megakaryopoiesis and behavioral defects in mafG mutant mice, Genes Dev. 12, 2164-74.
  13. Tanimoto, K., Bungert, J., Liu, Q., and J.D. Engel (1999) Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice, Nature 398, 344-349.
  14. Lim, K.-C., Lakshmanan, G., Crawford, S. E., Gu, Y., Grosveld, F. and J.D. Engel (2000) Gata3 gene ablation results in embryonic lethality as a consequence of sympathetic nervous system-specific catecholamine deficiency, Nature Gen. 25, 209-12.
  15. Tanimoto, K., Liu, Q., Grosveld, F., Bungert, J. and J.D. Engel (2000) Context-dependent EKLF responsiveness defines the developmental specificity of the human ε-globin gene in erythroid cells of YAC transgenic mice, Genes Dev. 14, 2778-94.
  16. Motohashi, H., Katsuoka, F., Shavit, J., Engel, J.D. and M. Yamamoto (2000) Positive or negative MARE-dependent transcriptional activation is determined by the abundance of small Maf proteins, Cell 103, 865-75.
  17. Tanabe, O., Katsuoka, F., Campbell, A.D., Song, W., Yamamoto, M., Tanimoto, K. and J.D. Engel (2002) A candidate erythroid embryonic/fetal globin gene repressor contains a nuclear orphan receptor TR2/TR4 heterodimer, EMBO J. 21, 3434-42.
  18. Tanabe, O., Shen, Y., Liu, Q., Campbell, A., Kuroha, T., Yamamoto, M. and J.D. Engel (2007) The TR2 and TR4 Orphan Nuclear Receptors Repress Gata1 Transcription, Genes Dev. 21, 2832-44.