Workshop Schedule / Detailed Outline | |
Workshop Agenda | This is a detailed outline of Days 1 and 2 of a typical 2-day workshop, including a description of modules and exercises. |
Workshop Preparation | |
Workshop Preparation Instructions | These are pre-workshop instructions. Follow these instructions to install PROC QLEARN and to test that SAS works on your machine. We will use SAS on Day 2 of the workshop. PROC QLEARN is a SAS add-on that implements Q-Learning Regression. |
Workshop Preparation Files | You will need the files contained inside of this ZIP to go through the Workshop Preparation Instructions. To download, right-click and select "Save Link As..." |
Slides and Handouts | |
Module 1 Slides, AIs | Adaptive Interventions (AIs): What are AIs? Why do we need them? How can AIs be used to inform clinical practice? |
Module 2 Slides, SMART | Sequential Multiple Assignment Randomized Trials (SMART): What are SMARTs? Why do we need them? SMART design principles. SMART sample size considerations. |
SMART Case Studies Handout | SMART Case Studies Handout: A PDF file describing the five (5) SMART to be discussed in Module 3 on SMART Case Studies. |
Module 3 Slides, SMART Case Studies | A review of five (5) actual SMARTs. These slides compare and contrast each of the four SMART study designs on dimensions such as: rationale for the SMART, what are the SMART-embedded tailoring variables, what are the SMART-embedded adaptive treatment strategies, what are the primary analyses, what are the secondary analyses. |
ADHD Handout | This handout describes the ADHD SMART study (PI: William Pelham, Florida International University) and the variables in a data set that was simulated to mimic the ADHD SMART study (see below for data set). The ADHD SMART study is used as the prototypical SMART design to describe the SAS analyses in Modules 4, 5 and 6. |
Module 4 Slides, Primary Analyses I | Primary Data Analyses using data arising from a SMART, Part I: Main effect of first-stage tactics. Comparing second-stage tactics. We use the ADHD SMART study as an example in these slides. |
Module 5 Slides, Primary Analyses II | Primary Data Analyses using data arising from a SMART, Part II: Weighting-and-replication approach to estimate and compare mean outcomes under the SMART-embedded adaptive treatment strategies. We use the ADHD SMART study as an example in these slides. |
Module 6 Slides, Secondary Analyses | Secondary Data Analyses using data arising from a SMART: Q-Learning Regression to develop more richly-individualized adaptive treatment strategies using data arising from a SMART. This module also teaches investigators how to use SAS add-on PROC QLEARN to implement Q-Learning Regression using data arising from a SMART. We use the ADHD SMART study as an example in these slides. |
SAS Code to Accompany Slides and Practice Exercises | |
ADHD Handout | This handout describes the ADHD SMART study (PI: William Pelham, Florida International University) and the variables in a data set that was simulated to mimic the ADHD SMART study (see below for data set). The ADHD SMART study is used as the prototypical SMART design to describe the SAS analyses in Modules 4, 5 and 6. |
Simulated ADHD Data Set | The ADHD SMART study has been completed. This data set was simulated to mimic data arising from the ADHD SMART study. This is NOT the actual ADHD SMART study data set. [SAS data format][TXT data format] |
SAS Code to Analyze ADHD data | This file provides SAS code to implement the analyses in Modules 4, 5, and 6 using the simulated ADHD data set. |
SAS Output for ADHD Data Analysis | After running the SAS code above, your SAS output should match the contents of this file. |
R Code to Analyze ADHD data | This file provides R code to implement the analyses in Modules 4, 5, and 6 using the simulated ADHD data set. This code is provided courtesy of Audrey Boruvka, PhD. |
R Output for ADHD Data Analysis | After running the R code above, your R output should match the contents of this file. This output file is provided courtesy of Audrey Boruvka, PhD. |
Other Workshop Files | |
FAQ | We have begun compiling a Frequently Asked Questions handout based on common questions and concerns that are raised about SMARTs during our workshops. Please email Daniel Almirall with questions or concerns to add to this list. |
First Published: 4/29/2011; Last Revised: 07/16/2014