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We must often control and change our behavior in response to environmental cues - when a stoplight turns red, we stop the car. Failing to control our behavior in response to such cues can have serious consequences. Successful control involves processes that activate the frontal and parietal regions of the brain. Human neuroimaging studies show that increasing demands for control lead to increased activation in these regions. Animal studies show that the neurotransmitter acetylcholine plays an important role in the brain's response to demands for control. In this study, we will manipulate acetylcholine levels in the brain and, using fMRI imaging, observe how participants perform tasks varying in the level of demand for control. These findings will helpu us better understand the link between hemodynamic and neurochemical aspects of control in the brain. This project is supported by funding from the National Science Foundation. |
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