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Welcome to the Chronis Group

We are developing Micro/Nano Electroctro-Mechanical Systems (MEMS/NEMS) to address: (i) fundamental questions in neuroscience, (ii) clinical needs in the medical field.

Bio-MEMS/NEMS in NeuroScience. How do neural circuits generate behavior? How the functionality of neural circuits is alterted with age? We combine micro/nano fabrciation technology with bio-imaging approaches to study the nervous system of the nematode C.elegans in vivo.

We are also interested in developing solid-state nanoprobes for measuring membrane potential from neurons in vitro.

Bio-MENS/NEMS in Medicine. We are interested in engineering point-of-care diagnostic biochips as well as in implantable medical devices. By integrating microfluidic and microoptical components, we are developing innovative tools for monitoring infectious diseases in the developing world as well as novel biosensing approaches for monitoring traumamtic brain injuries and diseases related to high intraocular pressure.

The dialectic relationship between technology and science motivates our research!

 
 

 

The figure above depicts a microfluidic device for immobilizing a single worm either by applying a mechanical force or by creating an CO2 micro-enviromenet.

'CO2 and Compressive Immobilization of C. elegans on-chip'
Chokshi T.V., Ben-Yakar A. and Chronis N., Lab-on-chip (in press)

 

 


NEWS
Read our recent paper on Lab-on-chip on how to immobilize C. elegans.

 

 

CONTACT US
Lab Address:

2178 G.G. Brown

2350 Hayward Street

Mechanical Engineering Department

University of Michigan
Ann Arbor, Michigan 48109

lab phone: (734) 936-0343
fax: (734) 615-6647