| Person | [Birth - Death] | Spouse |
|---|---|---|
| Middleton | [? - ?] | |
| Ardon P Middleton | [? - Before 1922] | Caroline Hutchinson |
| Cynthia Middleton | [? - ?] | Micajah K Pickett |
| Elizabeth Middleton | [? - ?] | |
| Elizabeth Middleton | [? - (27 July-18 November 1740)] | |
| George Middleton | [? - ?] | Dinah |
| George Middleton | [12 July 1722 - (1743-1777)] | Hannah Fowler |
| Hugh Middleton | [? - ?] | |
| Jane Middleton | [? - After 1740] | John Richardson |
| John Middleton | [? - Before 1710] | Martha |
| John Middleton | [1686 - 25 March 1741] | Esther Gilberthorpe |
| John Middleton | [22 September 1712 - 3 February 1765] | Sarah Ivins |
| Joseph Middleton | [? - After 1794] | Avis Holloway |
| Martha Middleton | [1686 - 1767] | John Rogers |
| Mary Middleton | [? - After 1712] | |
| Miriam Middleton | [10 February 1766 - After 1795] | Aaron Ivins |
| Naomi Middleton | [? - ?] | |
| Nathan Middleton | [? - ?] | |
| Nathan Middleton | [? - ?] | |
| Nathan Middleton | [? - ?] | Judith Stokes |
| Nathan Middleton | [? - 1760] | Mary French |
| Phebe Middleton | [? - ?] | George Justice |
| Thomas Middleton | [? - 1704] | |
| Thomas Middleton | [? - ?] | |
| Thomas Middleton | [? - After 1712] | |
| Thomas Middleton | [? - ?] | Mercy Allen |
| William Middleton | [? - After 1712] |