Isaiah Pickett was the youngest of Micajah and Kizannah Pickett's children, but his parents separated soon after his birth. When he was young, Isaiah likely lived with Micajah and Micajah's second partner, Susannah Johns. The notes below, dated 1800-1812, suggest that Isaiah Pickett lived with his father, Micajah Pickett, in Rutherford County, North Carolina during that time.
1800 Micajah Pickett, the father of Isaiah Pickett, was listed in Morgan, Rutherford County, North Carolina. The household had one male age 0-10 [Isaiah?], 1 M age 10-15, 2 M age 45+, 2 F age 0-10, and 1 F age 25-44. 
1800 Micajah Pickett, the father of Isaiah Pickett, and Susannah Johns made an agreement about living as man and wife, recorded in Rutherford County, North Carolina. 
1803 Eleanor and William Griffin sold land to Micajah Pickett in Rutherford County, North Carolina. 
1804 April 29, John Fisher entered 50 acres in Rutherford County, North Carolina on both sides of Green River; bordered by Micajah Pickett and Thomas Justuce's old line. 
1805 February 11, William Mills enters 50 acres in Rutherford County, North Carolina, on both sides of Green R "between" his own lines; includes his own improvements where Micajah Pickett lives; discontinued "by order". 
1812 Isaiah Pickett and Nancy Cochran were married about this time. Two letters, written by descendants of Isaiah Pickett and Nancy Cochran, to great-grandson Ranald Wolfe in 1943 gave the following perspective:
So you are in the state [North Carolina] where your gay, young, great grandfather was born with a golden spoon in his mouth and a darky mammy for his nurse. At nineteen he ran across the state line into South Carolina and wooed a fifteen year old lass by the name of Nancy Cochran fore father Scotch Irish. They eloped on horse back taking their personal servants, slaves, with them. Isaiah - so his wife told her daughter-in-law, your grandmother [Elizabeth Page Pickett] some sixty years afterward; that her young husband and his gay companions would ride away on their horses, larking around at county dances, stopping without doubt at some way side inns and return in the wee hours of the night arouse his young wife to order the servants to get them all supper! Supper in those days was ... a regular banquet - undoubtedly - and wine, I bet! Some place, near Greenville S.C. close to state line. I think Bluff Pickett told me that a town is on the plantation of your great, great, grand-father Pickett who couldn't ride around the plantation in a day, it was so big and 800 slaves did the farming. I had a powerful good dinner, so Nancy used to say. ... Nancy's son Charles, her youngest of fourteen fought in Civil War to free those same slaves. Their other sons fought to keep them! ... Cochrans had irish blue eyes, the Pickett's black eyes. [extract of a letter from granddaughter Arielle Pickett]
... the Carolinas is where the Pickett's lived. Where my grandfather [Isaiah Pickett] stole the little Irish girl and galoped away with her and was married. His father disinherited him because her father's estate was much smaller that the Pickett estate. [extract of a letter from grand-daughter Petrovna Pickett Wolfe]
1822 Isaiah Pickett granted to brother James Pickett "all lands bought by Pickett from Robert Cook" from the Int Estate of his father, Micajah Pickett. [Greenville County South Carolina Deed K-105, letter hard to read, perhaps N or R]
1823 Isaiah Pickett stated that he was a claimant under the will of his father Micajah Pickett and had received in January 1823 a negro man named Ned appraised at $525, a negro Lucy and her child Bill appraised at $500, a negro girl named Daphne appraised at $400, and $1000 from Japtha Pickett. Isaiah acknowledged receipt of $2425 on the bond for the estate of Micajah Pickett, which would be credited on his portion of the bond. Isaiah received of James Pickett $610 for Isaiah's interest in the land and personal property of the will of Micajah Pickett, signed 25 August and witnessed 6 August. 
1824 Isaiah Pickett purchased an 18 year old negro woman from John Crymes for $400. Witnessed by Thos Blyth, Benjamin Lynch, and S D Shumate, JP. 
1825 Isaiah Pickett certified, to William Choice esquire and sheriff Nimrod Underwood (of Greenville), what he had received from the estate of Micajah Pickett, which included negroes for $1500 to $1600; land sold for $650; and $1000 from Jeptha Pickett. The negroes included Sam and Martha and Martha's child Mary who were to be sold to satisfy the decree of Kezannah Pickett and the amount and interest were to be retained until a final settlement was made. Signed 20 September by Isaiah Pickett. 
1825 I[saiah?] Pickett lived in Greenville County, South Carolina, near the North Carolina border  This was in Pickett's Valley where [brother] James Pickett was postmaster, beside the north fork of the Saluda River [south of the letter "L" in Carolina on the map]. This was likely part of the land purchased by father Micajah Pickett in 1811-1815. [Photocopy, I Pickett on 1825 map (Part of Mills' 1825 Greenville Co, South Carolina atlas).] [Photocopy, Map: Pickett valley south of state border in Greenville Co, South Carolina.]
1827 The heirs of Micajah Pickett granted power of attorney to James Pickett to sell land. 
1828 Isaiah Pickett stated that he had received negroes and payment valued at $2425 on the bond of his father Micajah Pickett and his wife Kezannah Pickett, which was to be credited to James Pickett and all the balance due to Isaiah on the Will was to be paid to James. Dated 27 Feb 1833. 
1829 "In Equity. Greenville District. Charles Pickett vs. Jeptha Pickett, et al. The complainant having filed his bill in this court, and it appearing to the court that the defendants, Jeptha Pickett, Isaiah Pickett, Micajah Pickett, and Rufes K Pickett, reside beyond the limits of this state: - It is ordered that they do plead, answer or demur, to the said Bill within three months from this date, or the same will be taken pro con fense against them. William Choice, Commis'r Equity. March 21, 1829." 
1830 A complaint was brought by W Ellison that Isaiah Pickett's brother Jeptha Pickett had sold land in Fairfield District to which he was not fully entitled, had then moved to Georgia, and had then passed off the notes that had been made in payment for the land to Isaiah.  [Photocopy, Jeptha Pickett sold land of Isaiah Pickett, newspaper clipping.]
1830 Isaiah Pickett (age 30-40) lived in Franklin County, Georgia in a household with Males: one age 0-4 (Hiram), one age 5-10 (Isaiah Cochran), one age 10-15 (James Monroe), one age 15-20 (Micajah Cochran), one age 30-40 (Isaiah); and Females: two under age 5 (Rachel and Catherine), and one age 30-40 (Nancy) and no slaves. 
1831-33 Isaiah Pickett paid taxes in Franklin County, Georgia. 
1836 Isaiah Pickett and wife moved from South Carolina to Washington Twp, Darke County, Ohio and "squatted" on land near Flory's, on Greenville Creek; later he moved to Hillgrove, and built a small house just East of the Methodist Church, where he remained a few years, and later, moved to land between Hillgrove and Union City. 
1840 Josiah Riket [Isaiah Pickett] (age 40-50) lived in Jackson Twp, Darke County, Ohio in a household with Males: age 5-10 (John Henry?), 10-15 (Hiram?), 15-20 (Isaiah C), 40-50 (Isaiah?); and Females: 5-10 (Mary Jane?), 10-15(Katherine and Rachel?), and 40-50 (Nancy). 
1850 Isaiah Picket (age 57 born in South Carolina) and wife Nancy (age 54 born in South Carolina) lived in Jackson Twp, Darke County, Ohio. Also listed in the household were John (age 16 born South Carolina), farmer; Charles (age 9, born Ohio); I.C. (age 23, born South Carolina), farmer; and Mary (age 26)(plausibly daughter-in-law Mary Marquis married to Isaiah C) born Ohio. The household of William Marquis, next door neighbor, included Mary Pickett, age 18 (plausibly Isaiah's daughter), born South Carolina. The other adjacent listing was for Hezekiah Fowler with son Hezekiah Jr, who had married Isaiah Pickett's daughter, Catherine, earlier in the year. 
1854 Son Isaiah C Pickett of Darke County, Ohio patented land at the Iowa City, Iowa land office for section 29, township 21, range 9 west. Signed by president Franklin Pierce.
1855 Isaiah Hinson Pickett died. He was buried at Parents cemetery in Darke County, Ohio. His will was dated 13 February, 1855 and was in probate on 9 April, 1855. The will stated  [Photocopy, Isaiah Pickett's 1855 will.] [Photocopy, Isaiah Pickett's 1855 will, page 2.]:
In the name of the Benevolent Father I Isaiah Pickett of Darke County Ohio do make and publish this my last will and testament. First, I give and devise to my Beloved wife one horse wagon and give her two horses and two horses and all the money in hands and all the notes I hold against JB Malach in Mercer County, Ohio.
I do hereby nominate and appoint George W Marquess Administrator of this my last will and Testament hereby authorizing and empowering him to compromise, adjust release and discharge all my just debt out of the above named money and sell the above men'ed team and purchasing a homestead for my wife and I do hereby empower her to sell and buy or [?] so to suit herself by the advise and consent of my administrator and further [?] my administrator to see that all this is kept in order during her lifetime.
In Testimony whereof I have affixed my hand and Seal this 13st day of February AD 1855.
Signed and acknowledged by Isaiah Pickett as his last will and testament in our presence and signed by us in his presents Jacob Root [?]" Isaiah (mark) Pickett.
1855 May 23, letter: Son James wrote from Ringgold, Louisiana to son Micajah on the occasion of Isaiah's death. Note that Daniel Barnhouse was the husband of Isaiah's daughter Rachel. Daughters Catherine and Mary Jane were both married to Fowlers, although their husbands may not have been brothers. 
I got your letter from the office yesterday after having lain there for some time. In fact, I get a letter so seldom that I hardly think it worth to inquire for one even when I'm at the Post Office.
I had, a few days previously to the receipt of yours, got a letter from D. Barnhouse and brother Charles informing us of the death of our father, but it did not state the disease as your letter did. Our father was not very old, but on account of dissipation, premature infirmities, I suppose, must have enfeebled his constitution and have laid the foundation for consumption many years, perhaps, were the final dissolution.
The other news from Ohio is of the same terror with that received in your letter. The Messrs. Fowler and families have moved to Illinois, at work for the Rail road at $1.25 per day and are doing well. I did not get their address.
Mary E. Barnhouse writes in her father's letter with her own hand that she is 11 years old, is going to school, has two pretty little sisters, etc. and shows herself to be quite promising. Charles writes he is 19 years old, that John has been teaching school, but is now gone back to Mercer County to improve his land.
In relation to the Louisiana kin -- Talmon has been dead 3 or 4 years, Disease-Epilepsy. He died on Beoff or Bef river in Moorhouse Parish, Louisiana. I never saw him after I came out west. He has 4 children only living viz. - Thomas and Green B whose address is Ion, La. and James Monroe and Colquit, whose address was, the last I heard of them, Caushattee Chute, e.e. changed now to Springfield, La. The first two are married. All are poor.
Do you still own John yet? Have you bought any negroes? Are you as well off as when you moved there? When did you hear from Uncle Charles and Aunt Fanny? How are they, where do they reside, and what is Uncle Charles' address?
As to James C., he has lately removed to Georgia, having lost 2 wives and several children. He had, when he left the state 3 children living, 2 girls and 1 boy. His eldest daughter, Elizabeth, is grown. Reuben's widow still resides near Red River in the neighborhood which James C. left. She has a son-in-law named Julius Veecher, a Creole Frenchman, and quite a fine man, and prominent too. Besides Veecher's wife, Nancy, Cousin Patsy has 2 children Clayton and Francina.
Wm.E. Beckham, Martha's husband, resides in this neighborhood and doing well, I believe, the best, of any of Uncle Jeptha's sons-in-law. He has 2 little negroes and a tract of upland, pretty well fixed.
Dr. William Pickett resides with Mr. Beckham and smart one in medicine, according to the Thompsonian humbug. He is quite a gentlemanly fellow but has a great resemblance to the Simmons in his language and deportment. I think he will do well. He is temperish.
And now, having finished with others, I come to speak of ourselves. In the first place, we are all well, thank the Disposer of all Blessings. We are living at the same place where we have resided for the last 5 ½ years. We have 5 children, none dead, all sound, healthy and sensible. Two are going to school this year. They are Nancy 12 years old nearly, Micajah 8, Martha 8 nearly, Molly 2 ½ and Bet 2, and another close at hand. Eliza says you all had better come out here where you can raise lots of children and have good health. I think if I could sell out here, I should go to a better range. The grass has given entirely away since I came here.
I am sadly in debt as usual, and do not know how to get out, unless I do like James C. - "cut dirt". I am trying to make a living. I have 30 acres of corn planted, it looks tolerably well, is not full, but needs rain very, very much, having had no season of rain on it in 7 weeks and 2 days, and most of it has never had any rain since it was planted. Except in 1851, I have never seen a drier year. So for this last year, it did not rain here from the middle of April till the 3rd of August and this year, it has not rained since the third of April, save a very light skimmer, that did not penetrate down to the roots of vegetation. The weather is now clear and extremely warm, and except a very thin white skirt of vapor not a cloud is to be seen above the horizon. The air in the shade is now pleasant but it is ever varying and ever changing, frequently opposing currents meet in the fields or about the house, producing beautiful little dancing whirls - lifting the dust and leaves in swelling spiral columns ever as high as the tallest trees. A dozen to twenty of these whirlwinds occur in sight each day. I take them as signs of a continued drought. Last year proved to be a very bad crop year, Red river has failed to rise this year, and we have no navigation, the last cotton crop is still in the warehouses or gin houses not shipped nor sold, there is neither coffee, nor sugar in this county, nor whiskey, nor iron, nor much tobacco, nor flour nor molasses, nor current money. Corn is worth just anything you choose to ask. Many have quit plowing, in fact, I believe, nearly all; some for want of money, some on account of the drought. God alone knows what the country will do unless it rains shortly. Still, crops that are so fortunate as to have come up before it got too dry, look prosperous enough.
I am not teaching now, but farming. I have had to allow part of my ground to remain unplanted, by reason the dry weather. Eliza sends her love to Rachel (Barnhouse) and the children, also to you and Hiram and Mary Ann. Please receive the same from me. I don't know when I can come to see you. I hardly ever get that much money, but come see us, you can lay your warrant almost anywhere you please, plenty Public land.
Tell Hiram I want to see him very much, and to write. I would like well for us three to get together & colonize some place in Texas. And, in fact, I think by doing so, the Ohioans may come and settle with us. If I move, I must go to where wheat will grow. Flour cannot be got here now.
June 30th - Dear Brother, not having sent the letter to Post Office, I'll say I got a pretty good rain yesterday and last night, prospects for a good, year here abouts are now highly flattering. All well so far ... Adios. .J.M.P.
(James M.Pickett) .
1855 The estate of Isaiah Pickett was executed by George Marquess, a brother-in-law of son Isaiah Cochran Pickett. Three notes from ? Manlash were due to the estate for a total of $307.40 and personal items were valued at $116.12 for a total estate of $423.52. Items listed for his estate included gray? horse, hand organ, bay horse, two hand gun sets, tobacco, sundries, primer, vial cinnamon, coffee, muslin, needles, cake of shaving soap, fur skin, cumerine, 6 yards shrouding, drafting blotter, gloves, silk hdkf?, and 6 yards calico . Pecket, Isaiah - book A page 225 Dated 12 February 1855-recorded 9 April 1855. Wife - mentioned not named. Mentions notes on I.B. Malash of Mercer County, Ohio administrator - George W. Marquess. Signed Isaiah (X-mark) Pecket. Witnesses: Jacob Root and John Nowlin. Bond - George W. Marquess. Sureties -John Nowlin and R.K.Pense. One receipt gave the settlement of $115.12 for Isaiah Pickett's estate to wife Nancy Pickett and was signed by her X mark. [Photocopy, 1855 Receipt from Isaiah Pickett's estate, marked by widow Nancy Cochran Pickett.]
1857 W.K. Marquess and M.C. Page owned land in Jackson Twp, Darke County, Ohio . It is likely Charles Pickett and Elizabeth R Page, who would marry in 1865, were living in these households. [Photocopy, 1857 Darke County, Ohio atlas map with land of MC Page and WK Marquess.]
1859 On 1 November, Isaiah C Pickett of Cedar County, Missouri made two land purchases for 40 acres and 160 acres of land in Cedar County, Missouri. 
1859 Nancy and sons Isaiah C and John H Pickett bought land in Cedar, Missouri, deeded through the Bureau of Land Management by President James Buchanan. 
1860 Nancy Pickett (age 63, born NC), widow, and Charles T Pickett (age 19), teacher, lived in Clintonville, Box Twp, Cedar County, Missouri. James H Marques (maiden name of son Isaiah's wife)(age 25, born Virginia) lived nearby. 
1870 Nancy Pickett (age 74, born NC) lived in JacksonTwp, Darke County, Ohio, with $2500 real estate and $800 estate living with son Charles T Pickett. 
1871 On February 16, Nancy Pickett wrote from Union City, Indiana to son Micajah, in Florida, indicating that she was living with Charles and Isaiah Pickett. 
Dear Son and Family, I am thankful that I am Spared and have the prividege to write to you in my life. I have thought often of you and thought that I would write but neglected it. It has been many years since I last Saw you but have not forgotten you. A mother loss is great. I have looked for you But all in vain but Still hope that I may be blessed to See you once more. I am getting old and feable, and have no home that I can call my own Property I lossed all in the time of war. I am living with Charles and working what little I can. I am working for my bard. I am Sometimes with Isaiah but mostly with Charles. I am very destitute of cloths and am in need and if you can help me I would be very thankful. I would be thankful for but little and want but little long for I think I will no be here long in this world. And if you can help me an Why do So and if it is but a Small help it would come very good. I am torable well and want you to write to me and tell me how Hiram family is. How thankful I would be to here for you and would be glad to have you Send me a little money to get me Some warm clothes for I am very destitute. It has been a very cold winter here. I will close for this time. I hope you will write to me Soon. I think of you often my prayers and Love to you all. Your Affectionate Mother Nancy Pickett. To her son Mycajah C. Pickett.
1872 Nancy Pickett died. She was buried at Parents cemetery in Darke County, Ohio.
Charles Theodore Pickett and Hiram William Pickett, children of Isaiah Hinson Pickett and Nancy Cochran, have descendants with a DNA match suggesting a relationship as 4th cousins. Our genealogy research and the tree of the other descendant suggest a relationship of 3rd Cousin (1x removed). 
1836 A different Isaiah Pickett, of Chatham County, North Carolina, (listed here to show that there was another person) purchased land in Hamilton County, Indiana (land grant signed by president Andrew Jackson). This appears to be a different Isaiah Pickett: see census entries of 1840 and 1850 in Chatham County, North Carolina.
1840 A different Isaiah Pickett, (age 40-50) lived in Chatham County, North Carolina with 5 sons and 4 daughters and 2 free colored persons.  Note, this appears to be a different Isaiah Pickett (see census entry below for 1850 in Chatham County, North Carolina)
1850 A different Isaiah Pickett, age 58 born in NC, and wife Phebe age 56 lived in Chatham County, North Carolina with children Alfred, John, Alson, Calvin, and Anna. This Isaiah is also listed in "North Carolina 1850 Agricultural Census" By Linda L. Green, page 55. This could be the Isaiah Picket who bought land in Indiana in 1836. 
 United States Census, 1800, line 6 from bottom, [FamilySearch_Image], [FamilySearch_Record].
 North Carolina Probate Records, 1735-1970, Rutherford, Will B-55, [FamilySearch_Image].
 USGenWeb Archives, Deed/20-21/127 & 128/1803, [USGenWeb].
 A. B. Pruitt, Abstracts of Land Entries: Rutherford Co, NC, May 1826-June 1834 (1994), 6, citing page 16.
 A. B. Pruitt, Abstracts of Land Entries: Rutherford Co, NC, May 1826-June 1834 (1994), 13, citing page 32.
 Anne K. McCuen. Abstracts of Some Greenville County, South Carolina, Records Concerning Black People Free and Slave 1791-1865, Vol. 1 (1991), 76, citing Court abstract # 246, Vol R-105, [Google].
 Anne K. McCuen. Abstracts of Some Greenville County, South Carolina, Records Concerning Black People Free and Slave 1791-1865, Vol. 1 (1991), 57, citing Court abstract # 190, Vol O-355, [Google].
 A. B. Pruitt, Abstracts of Deeds: Greenville Co, SC Books N,O&P (1823-1828) (2007), 79, citing Greenville Co, South Carolina Deed O-355.
 Anne K. McCuen. Abstracts of Some Greenville County, South Carolina, Records Concerning Black People Free and Slave 1791-1865, Vol. 1 (1991), 57-58, citing court case #191, Vol O-322, [Google].
 A. B. Pruitt, Abstracts of Deeds: Greenville Co, SC Books N,O&P (1823-1828) (2007), 75, citing Greenville Co, South Carolina Deed O-322.
 George Salmon, Greenville District, South Carolina (engraved by H.S. Tanner, 1820, Improved for Robert Mills' Atlas of the State of South Carolina, 1825), [Library_Congress], [Library_Congress].
 Greenville County, South Carolina Deed Q-160.
 Anne K. McCuen. Abstracts of Some Greenville County, South Carolina, Records Concerning Black People Free and Slave 1791-1865, Vol. 1 (1991), 77-78, citing Court abstract # 250, Vol R-145, [Google].
 Newspaper, Mountaineer Greenville, South Carolina, 25 April, 1829.
 Newspaper, Augusta Chronicle (Georgia), May 8, 1830.
 United States Census, 1830, [FamilySearch_Image], [FamilySearch_Record], [Catalog FHL film 7037].
 Georgia Tax Digests , 140 volumes (Morrow, Georgia: Georgia Archives), 1831, [Ancestry_Record], [Ancestry_Image].
 Georgia Tax Digests , 140 volumes (Morrow, Georgia: Georgia Archives), 1832, [Ancestry_Record], [Ancestry_Image].
 Georgia Tax Digests , 140 volumes (Morrow, Georgia: Georgia Archives), 1833, [Ancestry_Record], [Ancestry_Image].
 W. H. McIntosh, The History of Darke County, Ohio (W. H. Beers & Co: 1890), 394, [HathiTrust], [Google], [Internet_Archive].
 United States Census, 1840, [FamilySearch_Image], [FamilySearch_Record], [Catalog FHL film 20163].
 US census, 1850, Reel 0674, Image 505, family 44, [Internet_Archive].
 United States Census, 1850, [FamilySearch_Image], [FamilySearch_Record].
 Ohio Probate Records, 1789-1996, Darke, Will B-2A-225, [FamilySearch_Image], [FHL film catalog].
 Family Document, From the files of Elizabeth Brown Mills Stokoe.
 Garst Historical Museum, Darke County, Ohio (http://www.garstmuseum.org/genealogy.php). Genealogy Archives, Documents.
 J. Chase, Map of Darke County, Ohio, from surveys and county records (Philadelphia: S. H. Matthews, 1857), [Library_Congress].
 United States Bureau of Land Management Patent, [US_BLM].
 United States Bureau of Land Management Patent, [US_BLM].
 United States Bureau of Land Management Patent, [US_BLM].
 United States Bureau of Land Management Patent, [US_BLM].
 US census, 1860, Reel 613, Image 47, family 307, [Internet_Archive].
 United States Census, 1860, [FamilySearch_Image], [FamilySearch_Record].
 US census, 1870, Reel 1194, Image 487, family 315, [Internet_Archive].
 United States Census, 1870, [FamilySearch_Image], [FamilySearch_Record], [Catalog FHL film 552693].
 Family Document, From the files of Elizabeth Brown Mills Stokoe.
 Siblings Charles Theodore Pickett and Hiram William Pickett, children of Isaiah Hinson Pickett and Nancy Cochran, have descendants who have an Ancestry tree match and an Ancestry DNA match.
 US census, 1840
 US census, 1850