Brian D. Athey, Ph.D.


Associate Professor, Bioinformatics and Computational Biology
Departments of Psychiatry and Internal Medicine

Associate Director, UM Center for Computational Medicine and Biology (CCMB)

Director, Michigan Center for Biological Information (MCBI)

Director, Biomedical Informatics Program (BIP), Michigan Institute for Clinical and Health Research (MICHR)

Principal Investigator, NIH National Center for Integrative Biomedical Informatics
(NCIBI) The University of Michigan Medical School

 
What's on this Page?
  Biography
   

Dr. Brian Athey received his Ph.D. in Cellular and Molecular Biology (Biophysics concentration) from the University of Michigan (1990), with a research focus in macromolecular structural biology. Dr. Athey is currently an Associate Professor of Biomedical Informatics in the University of Michigan Medical School Departments of Psychiatry and Internal Medicine; Brian is also an Associate Professor of Bioinformatics and Computational Biology in the UM Bioinformatics Graduate Program, and he is an active course master in the Program. In addition, he is founding Associate Director of the University of Michigan Center for Computational Medicine and Biology (ccmb.med.umich.edu), which has responsibility for the university-wide bioinformatics  graduate program, interdisciplinary pilot grant programs, and for providing access to computing and data infrastructures for “omics” and systems biology technology throughout CCMB and beyond to medical school and campus researchers.  Brian is the Principal Investigator of the NIH National Center for Integrative Biomedical Informatics (www.ncibi.org), only one of seven NIH National Centers for Biomedical Computing (NCBC), a centerpiece of the NIH Roadmap initiative.  He is also the Director of the funded Clinical and Translational Sciences Award (CTSA) Biomedical Informatics Program, housed in the Michigan Center for Clinical and Health Research (MICHR). He has responsibility to direct the U-M Health Informatics Research Organization (HIRO), the U-M wide health informatics faculty consortium, and oversight of the MICHR Clinical Research Informatics Core. Dr. Athey is co-chair of the national CTSA informatics consortia working group.

During his Ph.D. thesis research in the 1980s, Brian proposed the double helical crossed-linker model for the structure of chromatin, at that time controversial, but now thought to be the correct model for this critical macromolecular complex, and featured in many textbooks.  In the mid 1990s, Brian served as the Director of Biological Imaging Programs at the Environmental Research Institute of Michigan (ERIM; now part of General Dynamics). Dr. Athey is also a founding member of the Michigan Nanotechnology Institute for Medicine and Biology (www.nano.med.umich.edu). Brian was also a longtime collaborator and friend for the world famous and late Professor Emmett Leith, the inventor of off-axis holography. He and Leith invented and demonstrated an incoherent white light holographic microscope in 2001 with their student Kurt Mills and collaborator David Dilworth.  Brian is well known for his work with the National Library of Medicine (NLM) Visible Human Project where he has been a leader in establishing a nationwide Internet2 end-to-end test-bed demonstration project with NIH/NLM sponsorship in collaboration with Pittsburgh Supercomputing Center (vhp.med.umich.edu). The NLM VHP naturally lead to the establishment of the very successful DARPA Virtual Soldier Project (VHP) (www.virtualsoldier.net), a nationwide consortium of which he was the Principal Investigator, which builds from the VHP to extend it from basic human anatomy to physiological modeling, functional simulation and prediction after a traumatic injury.  Many of these projects are well known internationally.  Dr. Athey has published over 50 papers in the scientific literature, and has given well over 200 talks nationally, including several keynotes and plenary talks.  Brian was awarded  a Peace Fellowship of the Federation of American Scientists (FAS.org) in 2000, for his efforts in the 1990s to prevent biological warfare and terrorism. He is also a founding board member of Scientists and Engineers for America (www.sefora.org).
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  Research Interests
   

‘Integrative Biomedical Informatics’ and ‘Translational Bioinformatics’: This research thrust is leading to increased understanding of systems models and mechanisms of human health and disease, and will contribute to our understanding of the basis of ‘individualized medicine’. These new disciplines involve integration of diverse bioinformatics data-types and information bases into disease-specific models and networks, allowing a researcher to explore the systems properties and complexity of biological and biomedical systems. This relies heavily on computer and information sciences, biostatistics, and bioinformatics. Several very fruitful collaborations across campus and the nation are already developing because of this work, being demonstrated initially with collaborators in the genetic heterogeneity of T2 diabetes mellitus (M. Boehnke, L. Scott), T1 diabetes complications of the peripheral nerves and of nephrons (E. Feldman, M. Kretzler), prostate cancer progression and gene fusion events (A. Chinnaiyan, L. Hood), and bipolar spectral disorders (M. McInnis). Gil Omenn is my major collaborator in these “driving biological problem” (DBP) projects. This integrative approach should also considerably speed discovery and validation of new and unexpected co-morbidities indicating shared pathways and mechanisms.

This is a new research thrust for me, started in the last four years, and is already quite productive, leading to several significant team-science based grant and contract activities I lead. The major efforts are 1) the NIH National Center for Integrative Biomedical Informatics, NCIBI.org; and 2) the Biomedical Informatics Program of the UM Clinical and Translational Sciences Award (CTSA) in the Michigan Institute for Clinical and Health Research (MICHR).

Future clinical research application foci include studying the co-morbidity of depression(s) and bipolar spectral disorder(s) with other diseases, syndromes, and behaviors including: T2 diabetes, heart disease, cancer(s), cigarette smoking and drug abuse. My Co-I role as informatics lead in the NIH-NHLBI “Re-Engineering the Clinical Research Network” contract has helped to deliver a prototype IT/clinical informatics system called the “Honest Broker” to integrate diverse elements of clinical research records to study disease co-morbidities in a HIPAA compliant manner.
An overall goal of this thrust is to develop and test informatics intensive techniques to better stratify and classify disease phenotypes of human research participants, leveraging the electronic patient record, and integrating these phenotypic records with personalized molecular information. The UM Comprehensive Depression Center (UMCDC) will serve as a personalized medicine testbed. It is hoped this approach will allow for the diversity and variation of human health and disease to be better understood.

Computational Multiscale Modeling and Simulation of Macroscopic and Microscopic Biological Systems: This research thrust has two components: 1) A ‘macroscopic’ Human Systems Biology (HSB) modeling and simulation thrust, building from earlier work on the NIH Visible Human Project (Anatomy), and the DARPA Virtual Soldier Project (Physiology, Function, Pathology); and 2) A ‘Microscopic’ cellular systems approach to further understand the hierarchal nature of the structure, function, and dynamics of the eukaryotic chromatin fiber. These are both long-standing research interests, and both involve multiscale theory, ontological descriptions and machine learning for extension and linkage to other informational components, cutting-edge integrative biomedical informatics, and experimental verification.

For the macroscopic HSB thrust, future work will focus on integrating the nervous system into existing human systems models which have ignored the nervous system thus far (i.e. neither the Visible Human nor the Virtual Soldier have an integrated nervous system, central or peripheral). This work will take advantage of my background in advanced imaging and image processing. Additional aspects will involve modeling structural variation and uncertainty, and also the development of novel web portals to disseminate the work and build a world-wide community. This latter goal is already starting, in partnership with the Physiome project and the existing Visible Human collaboratory I started 10 years ago (http://vhp.med.umich.edu). The goal of this work is to create the scientific and technical basis for the next generation Visible Human Project.

For the microscopic chromatin work, a bioinformatics approach integrating the genomics, transcriptomics, proteomics, and cellular systems biology layers will help to provide models of “active” and “inactive” chromatin substrates. ChIP-chip data from public databases such as the ENCODE Project, and from bioinformatics-informed experiments, will be used to provide initial conditions for modeling nucleosomal placement and occupancy on the genomic sequence. A major theme will be to understand the topological aspects of chromatin in the nucleus (in situ), modeling connections to the nuclear matrix and scaffold elements (MARs and SARs), and using algorithms to model the torsional and structural changes implicated by sequence and connection-state to the matrix and/or scaffold. The major goal will be the continued development and testing of the multiscaler theory of chromatin “under tension” to understand chromatin fiber structure transcriptional regulatory network (TRN) complexes, the transition between interphase and metaphase states, and other biologically interesting dynamics. This work is being done in collaboration with mathematician Daniel Burns, and several well-known experimental collaborators. I was the co-discoverer of the crossed-linker model of chromatin structure (refs. 1, 2, 3). This work is now widely accepted, but not proven definitively. I will endeavor to prove the proposed structure definitively in the next 5-7 years. This model will provide the basis upon which to understand the underlying mechanisms of transcription and its regulation.
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  Selected References
   

Athey BD, Smith MF, Rankert DA, Williams SP, Langmore JP (1990) The Diameters of Frozen-Hydrated Chromatin Fibers Increase with DNA Linker Length: Evidence in Support of Variable Diameter Models for Chromatin. Journal of Cell Biology 111:795-806. I was one of the co-discoverers of the Crossed-linker model for Chromatin. This is one of the key early references.

Dai, M, Wang P, Boyd AD, Kostov G, Athey BD, Jones EG, Bunney WE, Myers RM, Speed TP, Akil H, Watson SJ, Meng F (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Research 33(20):e175, pp. 1-9.

Kim YJ, Boyd AD, Athey BD, Patel JM (2005) “miBLAST: scalable evaluation of a batch of nucleotide sequence queries with BLAST.” Nucleic Acids Research 33(13):4335-44.

Wang P, Dai M, Xuan W, McEachin RC, Jackson AU, Scott LJ, Athey BD, Watson SJ, Meng F (2006) SNP Function Portal: A web database for exploring the function implication of SNP alleles. Bioinformatics Jul 15; 22(14):e523-529. PMID: 16873516.

Boyd AD, Hosner C, Hunscher DA, Athey BD, Clauw DJ, Green L (2007) An 'Honest Broker' Mechanism to Maintain Privacy for Patient Care and Academic Medical Research. International Journal of Medical Informatics 76(5-6):407-411, May-June 2007.

Jayapandian M, Chapman A, Tarcea VG, Yu C, Elkiss A, Ianni A, Liu B, Nandi A, Santos C, Andrews P, Athey BD, States D, Jagadish HV (2007) Michigan Molecular Interactions (MiMI): Putting the Jigsaw Puzzle Together. Nucleic Acids Research 2007, 35:D566-D571.

Xuan W, Dai M, Mirel B, Wilson J, Athey BD, Watson SJ, Meng F (2007) Pubviz: An Interactive Visual Search Interface for Medline. Proceedings of the Computational Systems Bioinformatics Conference (CSB2007) (in press).

Sarntivijai S, Ade A, Athey BD, States DJ, Lee AW (2007) Cell Line Ontology: A Bioinformatics Approach to Knowledge-Based Cell Culture Data Structure. Bioinformatics (accepted).
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Biographical Sketch
 
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  Brian D. Athey, Ph.D. Associate Professor/Bioinformatics and Computational Biology
Associate Director (UM) Center for Computational Medicine and Biology
Director, Michigan Center for Biological Information
Director, Biomedical Informatics, UM Depression Center
 
Institution & Location
Degree
Year(s)
Field of Study

St. John's College, Annapolis, MD
University of Michigan, Dearborn, MI
University of Michigan, Ann Arbor, MI

University of Michigan, Ann Arbor, MI

B.S.
Ph.D.

Postdoctoral
1975-1979
1982
1990

1990-1993

Classical Studies
Biochemistry, Physics
Cell&Mol Biol
(Biophysics)
Anatomy & Informatics
  Professional Experience
 
1995-1996
 Visiting Assistant Professor, Medical Informatics Graduate Program, UMich School of Information
 
1995-1998
 Director, Biomedical Imaging Programs; ERIM International, Inc.
 
1995-
 Assistant Professor, Department of Anatomy & Cell Biology (ACB), UMich Medical School
 
1997-2002
 Assistant Professor, School of Art & Design, UMich Graduate Program in Medical & Biological Illustration
 
1998-
 Research Investigator and Founding Member, Center for Biologic Nanotechnology, UMich Medical School Department of Internal Medicine
 
2000-2003
 Visiting Assistant Professor. UMich Electrical Engineering and Computer Science (EECS)
 
2000-2001
 Academic Liaison for Health Sciences Research & Instructional Computing, UMich Office of CIO
 
2000-
 Director, Michigan Center for Biological Information (MCBI), UMich Office of the Vice President for Research (OVPR)
 
2003-
 Associate Professor, Biomedical Informatics, Department of Psychiatry, UMich Medical School
 
2003-
 Director, Biomedical Informatics Core, UMich Depression Center
 
2003-
 Visiting Associate Professor, Electrical Engineering and Computer Science (EECS), College of Engineering, University of Michigan
 
2005-
 Associate Professor, Bioinformatics and Computational Biology, Bioinformatics Program, University of Michigan Medical School
 
2005-
 Associate Director, (UMich) Center for Computational Medicine and Biology (C
  Fellowship Honors
 
1992-1985
 NIH Pre-doctoral Fellowship, Cellular and Molecular Biology Training Program, University of Michigan Medical School; Ann Arbor, MI.
 
1990-1991
 NIH Postdoctoral Fellowship, Developmental Biology Training Program, University of Michigan Medical School; Ann Arbor, MI.
 
1991-1993
 Postdoctoral Fellowship, Chemical and Hearing Senses Training Program, Kresge Hearing Research Institute, The University of Michigan Medical School; Ann Arbor, MI
 
2000-
 Peace Fellowship, Federation of American Scientists (FAS)
 
2005-
 Conference Co-Chair, Intelligent Systems for Molecular Biology (ISMB); International Society for
Computation Biology (ISCB)
  Professional Societies
 
1982-1990
 Microscopy Society of America (MSA)
 
1994-
 Optical Society of America (Ann Arbor Branch)
 
2003-
 International Society for Computational Biology (ISCB)
 
2003-
 American Medical Informatics Society (AMIA)
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  Selected Peer-Reviewed Publications (of over 45)
 

 
  1. Williams, S.P., B.D. Athey, L.J. Muglia, R.S. Schappe, A.H. Gough and J.P. Langmore. 1986. “Chromatin Fibers are Left-Handed Double Helices with Diameter and Mass Per Unit Length that Depend on Linker Length.” J. Biophys., 49:233-248. (Plenary presentation for the 1985 Biophysical Discussions).
  2. Smith, M.F., B.D. Athey, S.P. Williams and J.P. Langmore. 1990. “Radial Density Distribution of Chromatin: Evidence that Chromatin Fibers Have Solid Cores.” J. Cell Biol. 110:245-254.
  3. Athey, B.D., M.F. Smith, D.A. Rankert, S.P. Williams and J.P. Langmore. 1990. “The Diameters of Frozen-Hydrated Chromatin Fibers Increase with DNA Linker Length: Evidence in Support of Variable Diameter Models for Chromatin.” J. Cell Biol. 111:795-806.
  4. Wetzel, A.W., A. Ade, F.L. Bookstein, W. Green and B.D. Athey. 2000. “Representation and Performance Issues in Navigating Visible Human Datasets.” The 3rd National Library of Medicine (NLM) Conference on the Visible Human. (Peer-reviewed electronic publication).
  5. Bookstein, F.L., B.D. Athey, W.D. Green and A.W. Wetzel. 2000. “Navigating Solid Medical Images by Pencils of Sectioning Planes.” Proceedings of SPIE, 4121:117-127.
  6. Higgins, G., B.D. Athey, J. Bassingthwaighte, J. Burgess, H. Champion, K. Cleary, P. Dev, J. Duncan, M. Hopmeier, D. Jenkins, C. Johnson, H. Kelly, R. Leitch, W. Lorensen, D. Metaxas, V. Spitzer, N. Vaidehi, K. Vosburgh and R. Winslow. 2001. “Modeling & Simulation in Medicine: Towards an Integrated Framework.” Comput. Aided Surg, 6(1):32-39.
  7. Hacker, T.J. and B.D. Athey. “A Methodology for Account Management in Grid Computing Environments.” Proceedings of the 2nd International Workshop on Grid Computing, November 2001, Denver Colorado, Lecture Notes in Computer Science, 133-144. Springer Verlag Press.
  8. Lee, I., B.D. Athey, J.R. Baker, A. Wetzel, W.M. Meixner and J.R. Baker, Jr. 2002. “Structural Molecular Dynamic Studies on Therapeutically-Applied Polyamidoamine Dendrimers: The Effects of pH and Surface Derivatization Group,” Macromolecules, 35(11):4510-4520.
  9. Walker, D.S., W.Y. Lee, N. Skov, C. Berger and B.D. Athey. 2002. “Investigating User Requirements: Computer-based Anatomy Learning Modules for Multiple User Testbeds.” JAMIA, 9(4):311-319.
  10. Thigpen, B., T.J. Hacker, L. McGinnis and B.D. Athey. 2002. “Distributed Accounting on the Grid.” Proceedings of the 6th Joint Conference on Information Sciences, pp. 1147-1150.
  11. Hacker, T.J., B. Noble and B.D. Athey, “The Effects of Systemic Packet Loss on Aggregate TCP Flows.” Proceedings of the 2002 ACM/IEEE Conference on Supercomputing, Nov. 2002, pp. 1-15.
  12. Singh, G.B., H. Song, D. Liu, D. Wildman, M. Goodman, C. Bliton, G. Kostov, and B.D. Athey, "A Non-Homology Method for Sensitive Information Retrieval from Biological Databases.” Proceedings of the 7th Joint Conference on Information Sciences, 2003, pp. 915-918.
  13. Lee, I., A. A. Dombkowski, and B.D. Athey. 2004. "Guidelines for Incorporating Non-perfectly Matched Oligonucleotides into Target-Specific Hybridization Probes for a DNA Microarray." Nucl. Acids. Res., 32:681-690.
  14. Boyd, A.D., D.J. DiFranco, and B.D. Athey, “Challenges of HIPAA Regulations in Academic Biomedical Research.” MEDINFO, 2004(CD):1535, Sept. 13, 2004
  15. You Jung Kim, A. D. Boyd, B. D Athey, J. M Patel, “miBLAST: scalable evaluation of a batch of nucleotide sequence queries with BLAST.” Nucleic Acids Res. 2005 33:4335-44.
  16. Boyd AD Wright ZC, Ade AS, Bookstein F, Ogden JC, Meixner W, Athey BD, Morris T., "Challenges in Presenting High Dimensional Data to aid in Triage in the DARPA Virtual Soldier Project." Studies in Health Technology and Informatics, 2004, 111, 68-74.
  17. Dai M, Wang B, Boyd AD, Kostov G, Athey BD, Watson SJ, Akil H, Speed TP, Meng F., “Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.” Nucleic Acids Research 2005 33(20):e175
  18. Boyd AD, Hosner C, Hunscher DA, Athey BD, Clauw DJ, Green L. "An 'Honest Broker' Mechanism to maintain Privacy for Patient Care and Academic Medical Research" presented at Secure E Health Conference, published online in International Journal of Medical Informatics (2006), doi:10.1016/j.ijmedinf.2006.09.004.
  19. Wang P, Dai M, Xuan W, McEachin RC, Jackson AU, Scott LJ, Athey BD, Watson SJ, Meng F. SNP Function Portal: a web database for exploring the function implication of SNP alleles. Bioinformatics. 2006 Jul 15;22(14):e523-9. PMID: 16873516 [PubMed - indexed for MEDLINE]
  20. Jayapandian M, Chapman A, Tarcea VG, Yu C, Elkiss A, Ianni A, Liu B, Nandi A, Santos C, Andrews P, Athey BD, States D, Jagadish HV. Michigan Molecular Interactions (MiMI): Putting the Jigsaw Puzzle Together. Nucleic Acids Research. 2007; 35:D566-D571.
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  Research Support Ongoing
   

BAA-RM-04-23 (Clauw, Daniel) 10/01/04 – 10/01/07 0.60 calendar
National Institute of Health/NHLBI
Michigan Clinical Research Collaboratory: An Integrated Academic-Community Research Enterprise

The major goal of this contract is to develop an “Honest Broker” system which will allow for the interaction of several distinct domains of the translational research medical record.
Role: Co-I

The major goal is to establish an Internet-based collaboration medical education teaching capability as part of the NLM SII program.
2 R01 AI 37141 (Baker, James R. Jr.) 05/01/04 - 04/30/09 0.00 calendar
National Institutes of Health-NIAID
Apoptosis in Thyroiditis. Role: Co-I

The major goal of this effort is to provide bioinformatics support for Dr. Baker’s project.
1 U54 DA021519-01A1 (Athey, Brian D.) 09/25/05 - 08/31/10 4.20 calendar
National Institute of Health
National Center for Integrative Biomedical Informatics (NCIBI)

This is one of the seven NIH National Centers for Biomedical Computing (NCBC). Focus is biomedical informatics data integration and modeling, including advanced biomedical Information Retrieval (IR).
Role: PI

GR-238 (Athey, Brian D.) 01/01/2001 - 12/31/2006 0.00 calendar
Michigan Economic Development Corporation (MEDC)
“The Michigan Center for Biological Information (MCBI)”
The major goal of this project is to provide statewide bioinformatics and computational biology capabilities to the Michigan Core Technology Alliance infrastructure partners and institutions. Now working in no-cost extension.
Role: PI
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  Completed
   

W81XWH-04-2-0012 DOD-Army, Athey, B.D. (PI) 12/01/2003 - 09/31/2006
Defense Advanced Research Projects Agency/DSO
“Core development, integration and demonstration of the DARPA Virtual Soldier”.
This multi-institutional project prototypes and integrates anatomical and physiology modeling, medical informatics and computer simulations to create the next generation “Digital Human” framework; with military applications.
Role: PI, 12 subcontracting sites.

NO1-LM-0-3511 Athey, BD (PI) 11/22/1999 - 11/21/2004
NIH/NLM-National Library of Medicine
“Biomedical Applications of the Next Generation Internet (NGI): Next Generation Internet Implementation to Serve Visible Human Datasets: Phase II – Development of Testbeds”.
The major goal of this project was the creation of Internet2 Visible Human navigation and software capability.
Role: PI

MEDC #270 Athey, BD 10/01/2002 – 10/01/2004
Michigan Economic Development Corporation (MEDC)
DNA Software, Inc.
“Development of a comprehensive simulation-based computer software system environment for designing DNA-based microarrays”.
The major goal of this project is to provide design consideration for the development of the user interface of the microarray Designer Software System.
Role: PI
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  Pending
   

1 U54 RR023422-01 (Clauw, Daniel) 09/30/2007 – 09/29/2012
NIH / NCRR
Michigan Institute for Clinical and Health Research (MICHR)
Role: Director of the Biomedical Informatics Program, Co-Investigator

Burant, Charles (PI) 08/01/07-07/31/2012
National Institute of Health
“Using Systems Biology to Understand Islet Adaptation and Failure in Diabetes”

The goals of this application are to combine novel metabolomic analysis techniques with bioinformatics to identify the way in which pancreatic islet adapt to differences in nutrient mix and supply.
Role: Co-I
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  Curriculum Vitae
 

Personal Data
Printer friendly .pdf version
   

Brian David Athey
Web Sites:

https://portal.ncibi.org/portal
http://vhp.med.umich.edu/,
http://www.ctaalliance.org/MCBI/index.html
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  Education
 
1971-1975
 Diploma, University of Detroit High School; Detroit, MI High Honors
 
1976-1977
 St. John's College; Annapolis, MD (Major: Classical Studies)
 
1980-1982
 B.S.(Major: Biochemistry, Minors: Physics and Mathematics)
University of Michigan-Dearborn: Dearborn, MI
School Record: 128 Credits in 2 years
 
1982-1990
 Ph.D. (Cellular and Molecular Biology--Biophysics Concentration)
(J.P. Langmore, Dissertation Chair)
University of Michigan; Ann Arbor, MI
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  Postdoctoral Training
 
1990-1991
 NIH Postdoctoral Fellowship(M.J. Welsh, Advisor)
Developmental Biology Training Program
University of Michigan Medical School; Ann Arbor, MI
 
1991-1993
 NIH Postdoctoral Fellowship
(R.A. Altschuler and D.J. Anderson, Advisors)
Chemical and Hearing Senses Training Program
Kresge Hearing Research Institute(KHRI)
University of Michigan; Ann Arbor, MI
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  Senior Postdoctoral Training
 
1998
 CNS Anatomy Course, St. Hugh's College, Oxford University(UK)
Professor J.F. Morris, Advisor
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  Academic Appointments
 
1991-1993
Adjunct Lecturer, Department of Biology
University of Michigan
 
1994-1995
Lecturer, Department of Anatomy and Cell Biology
University of Michigan Medical School
 
1995-1998
Assistant Professor, Department of Anatomy and Cell Biology
University of Michigan Medical School
 
1996-1998
Visiting Assistant Professor
Medical Information Graduate Program
University of Michigan School of Information
 
1997-2000
Assistant Professor, Graduate Program in Medical Illustration
University of Michigan School of Art and Design
 
1998-2003
Assistant Professor, Cell and Developmental Biology
University of Michigan Medical School
 
2003-
Associate Professor, Department of Psychiatry
University of Michigan Medical School
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  Administrative Appointments
 
2000-2001
 Academic Liasison, Research and Instructional Computing for the Health Sciences; Director, University of Michigan Visible Human Project; UM Office of the Chief Information Officer (CIO)
 
2001
 Interim Director, Michigan Center for Biological Information (MCBI)
UM Office of the Vice President for Research (OVPR)
 
2001-
 Director, Michigan Center for Biological Information (MCBI)
UM Office of the Vice President for Research (OVPR)
 
2003-
 Director, Biomedical Informatics Core
Department of Psychiatry and University of Michigan Depression Center
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  Industrial Positions  
 

1995-1998


1998-

Director, Biomedical Imaging Program
Environmental Research Institute of Michigan; Ann Arbor, MI

Environmental Research Institute of Michigan; Ann Arbor, MI
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  Consulting Positions
 
1988
 Virogen Laboratories, Inc.; Ann Arbor, MI
Automated, Molecular Biology-based Viral Detection Systems
 
1993-1995
 Convex Computer Corporation; Richardson, TX
Medical Image Processing, Storage and Retrieval
 
1995
 I-MED Link, Inc.; Bethesda, MD
Internationally Distributed Telemedical School Networking
 
1995-1996
 Hoffman-La Roche, LTD.; Toronto, Canada
Medical Image Processing
 
1996
 Meridian Instruments, Inc.; Okemos, MI
Laser Scanning Confocal Microscopy
 
1997
 LaBat-Anderson Consulting, Inc.; McLean, VA
Secondary Reviewer for Medical Free-Electron Laser Grants Program Office of Naval Research(ONR)
 
1997-1999
 Potomac Institute for Policy Studies(PIPS); Arlington, VA
Technology Consultant for DARPA Unconventional Pathogen Counter-measures(UPC) Program
 
1999-2000
 Innervision Imaging, Inc.; Farmington Hills, MI
Microscopic Laparoscopy
 
2000
 Telemed, Inc.; Annapolis, MD
High Performance Medical Modeling and Simulation for Surgical
Trauma Applications
 
2000
 Ethereal Technologies, Inc.; Ann Arbor, MI
3-D Display Technology
 
2001-
 Altarum Institue; Ann Arbor, MI
Novel Medical and Life Sciences Applications
 
2002
 U.S. Army Medical Research and Material Command
(USAMRMC); Ft. Detrick, MD
CBNR Responsiveness Training Network Architecture
 
2003-
 SimQuest International, Inc.; Silver Springs, MD
Medical training software and systems
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  Scientific Activities
 
2003
 Reviewer/Panel Member, NIH Neuroinformatics Study Section ZRG1 SSS-E (55), Center for Scientific Review, National Institutes of Health
 
2003-
 Reviewer/Panel Member, NIH Human Brain Project Study Section
Scientific Review, National Institutes of Health
 
2003-
 Reviewer/Panel Member, NIH Neuroinformatics Study Section, Center for Scientific Review, National Institutes of Health
 
2003-
 Reviewer/Panel Member, NIH Biomedical Computing Review Panel, Center for Scientific Review, National Institutes of Health
 
2003-
 Reviewer/Panel Member, Integration of Middleware Review Panel, National Science Foundation
 
2002-
 Reviewer/Panel Member, NIH Computational Biology Study Section, Center for Scientific Review, National Institutes of Health(NIH)
 
2002
 Reviewer/Panel Member, Washington Advisory Group(WAG)
LLC, Missouri Life Science Research Capacity Contracts(MLSRCC) Program
 
2001
 Reviewer/Panel Member, Bioinformatics Study Section, ITR Small
Grant Awards, National Science Foundation(NSF)
 
2000
 Reviewer/Panel Member, Bioengineering Research Partnership
Grants, Special Study Section, National Eye Institute(NEI)/ National
Institutes of Health(NIH)
 
2000
 Reviewer, Army Research Office(ARO)
 
1995-1999
 Ad Hoc Reviewer: Office of Naval Research (ONR), Defense Advanced Research Projects Agency(DARPA)
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  Grant/Contract Support
  Past  
 
1992-1994
 "Further Development of the Laser Scanning Confocal Microscopy/
Digital Microscopy and Scientific Visualization Facility."
University of Michigan Office of Vice President for Research(OVPR).
B.D. Athey & D.J. Andersen, Co-Is; 0% effort; $90K direct costs.
 
1993-1995
 "Cellular Pathophysiology of Acute Renal Failure." NIH-RO1.
J.M. Weinberg, PI; B.D. Athey, Co-I, 5% effort.
 
1993-1994
 "An Image Based Repository of Bio-Medical Imagery." NIH/NLM
HPCC Demonstration Project. NIH-RO1. W.B. Panako, PI;
B.D. Athey, Co-I; 20% effort; $200K direct costs
(2 of 3 years: PI moved).
 
1994
 "Development of Data Processing Methodology for the Visible Human/Embryo Projects I: Fourier Encoding of Contours." Advanced Research Projects Agency(ARPA).
B.D. Athey; PI; 20% effort; $25K total costs.
 
1994
 "Feasibility Study of Sorbinil-Treated Sural Nerve Biopsies."
B.M. Carlson, PI; B.D. Athey, Co-I; 10% effort; 150K total costs.
 
1994-1995
 "The Integration of Kodak Photo CD Technology into a Modern
Biomedical Digital Imaging Environment."
B.D. Athey, M. Pao, and Co-Is; 0% effort; $25K total costs.
 
1994-1995
 "Scaleable System for Nerve Biopsy Analysis."
Hoffman-LaRoche, LTD(Toronto, Ont., Canada)
B.M. Carlson, PI; B.D. Athey, Co-I; 20% effort; 2.3M total costs.
 
1994-1996
 "Center for Neural Communication Technology." NIH-P41.
D.J. Anderson, PI; B.D. Athey, Co-I; 5% effort; Project 3.
$95K total costs.
 
1994-1996
 "Development and Demonstration of a Networked Telepathology
3-D Imaging, Databasing and Communication System: Phase I."
Advanced Research Projects Agency(ARPA).
B.D. Athey, PI; 25% effort; $636K total costs.
 
1995-1998
 "AASERT Graduate Fellowship in Advanced Biomedical Imaging."
Defense Advanced Research Projects Agency(DARPA).
0% effort; $114K total costs.
  Recent  
 
1997
 "Feasibility Assessment of Tissue Engineering, Regeneration and
Fabrication Technology for Defense Purposes."
The Potomac Institute for Policy Studies(PIPS).
B.D. Athey, PI; 40% effort; $75K total costs.
 
1998
 "Prospect: The Prostate Cancer Decision Support Architecture."
Internal Graduate Student Award from University of Michigan NIH
Prostate SPORE Grant.
K.J. Pienta, PI; B.D. Athey, Co-I; 0% effort; $5K total costs.
 
1998-1999
 "University of Michigan Next Generation Internet (NGI) Implementation to Serve Visible Human Datasets: Phase I."
NIH-National Library of Medicine(NLM) Contract.
B.D. Athey, PI; 15% effort; $100K total costs.
 
1999-2002
 “Nanomolecular Therapeutics for Cancer.” National Cancer Institute Contract. J.R. Baker, Jr., PI; B.D. Athey Co-I; 5% effort; Task 3—Imaging Component. $720K direct costs.
  Current  
 
1999-2002
 "University of Michigan Next Generation Internet(NGI) Implementation to Serve Visible Human Datasets: Phase II."
NIH-National Library of Medicine(NLM)
Contract #N01-LM-0-3511.
B.D. Athey, PI; $6.8M total costs.
 
1999-2002
 "Nanomolecular Therapeutics for Cancer."
National Cancer Institute(NCI) Contract.
J.R. Baker, Jr., PI; B.D. Athey, Co-I; 5% effort; Task -- Imaging Component; $1.1M total costs.
 
2001-2006
 "The Michigan Center for Biological Information."
Michigan Economic Development Corporation(MEDC).
B.D. Athey, PI; $10.15M total costs.
 
2002-2004
 "MEDC 270 - Development of a Comprehensive Simulation-Based Computer Software System Environment for Designing DNA-Based Microarrays."
Michigan Economic Development Corporation(MEDC).
B.D. Athey, PI; 0% effort; $62K total costs.
 
2002-2004
 “Novel Technologies for Noninvasive Detection, Diagnosis of Cancer.” National Cancer Institute–National Institutes of Health. Imaging subproject: $339K direct costs.
 
2003-2005
 BAA 02-03 Addendum 4, the Virtual Soldier. “Core Development Integration and Demonstration of the DARPA Virtual Soldier” Defense Advanced Research Projects Agency. B.D. Athey, PI, Phase I, 18months effort. $9.96M direct costs.
  Pending  
 
2003-2006
 NSF-02-168. “Collaborative Research: Language-Inspired Novel Algorithms for Searching Biological Databases.” National Science Foundation. Gautum Singh, PI; B.D. Athey, Co-I; $601,956 direct costs.
  ^back to top  
  Military Service
    None
  ^back to top  
  Honors and Awards
 
1982-1985
 NIH Predoctoral Fellowship
Cellular and Molecular Biology Training Porgram
University of Michigan Medical School; Ann Arbor, MI
 
1990-1991
 NIH Postdoctoral Fellowship
Developmental Biology Training Program
University of Michigan Medical School; Ann Arbor, MI
 
1991-1993
 NIH Postdoctoral Fellowship
Checmical and Hearing Senses Training Program
Kresge Hearing Research Institute(KHRI)
University of Michigan; Ann Arbor, MI
 
2000
 Peace Fellowship
Federation of American Scientists(FAS); Washington, D.C.
  ^back to top  
  Memberships in Professional Societies
 
1982-1990
 Microscopy Society of America(MSA).
 
1994
 Optical Society of America(Ann Arbor, MI branch)
 
1996
 Friends of the National Library of Medicine(NLM)
 
1997
 American Association of Anatomist(AAA)
 
2000
 The Society for Computer Simulation International(SCS)
  ^back to top  
  Teaching Activities
  Graduate Teaching Assistant  
 
1998
 Anatomy and Cell Biology 535: "Biological Electron Microscopy."
Teaching Assistant(TA) for second-year graduate course under
Professor A.K. Christensen.
  Course Lecturer  
 
1990-1993
 Biology 416: "Biophysical Chemistry."(UM Department of Biology)
Course directed toward undergraduate seniors and first-year graduate microbiology concentrators.
  Graduate Short Course  
 
1992
 Anatomy and Cell Biology 850: "A Short Course in Confocal Microscopy." A week-long graduate-level introduction to confocal microscopy and related computer image analysis and display techniques.
  Course Instructor  
 
1998
 School of Information(SI) 608: "Medical Informatics: Theory and Practice." Designed and taught jointly with Professor A.J. Warner.
 
1997-1998
 School of Art and Design 622: "Biomedical Graphical Computing for Artists." Assisted by Mr. Alex Ade(TA).
  Graduate Lectures  
 
1991-1994
 Anatomy and Cell Biology 530: "Cell Biology." Invited lectures on "The Structure of Chromatin" and "The Cell Nucleus."
 
1992-1994
 Engineering 503: "Scientific Visualization." Invited lecturer on "Visualizing Data Obtained From a Microscope." College of Engineering graduate-level course."
 
1993-1996
 Anatomy and Cell Biology 580: "Morphological Methods of Microscopy." Invited lecturer on "Basic Confocal Imaging: Theory and Practice." Directed towards second-year health sciences graduate students.
  Grand Rounds  
 
1996
 "Biomedical Diagnostic Imaging." University of Michigan Comprehensive Cancer Center Grand Rounds, University of Michigan Hospital.
  Departmental Seminars  
 
1992
 "Three-dimensional Visualization of Cells and Tissues Using the Confocal Microscope." Department of Anatomy and Cell Biology.
 
1992
 "Confocal Microscopy." Department of Surgery.
 
1993
 "The Light Microscopic Study of Tissues." Nephrology Division, Department of Internal Medicine.
 
1995
 "Medical Informatics, Telemedicine, and the Need for Medical Information Specialists--Oppurtunities and Challenges." UM School of Information.
 
1996
 "The Evolution of Microscopy as an Information Science." UM School of Information.
 
1998
 "Microscopic Holography, Holospaces, Range Imaging: Recent Results and Future Biological Applications." Department of Anatomy and Cell Biology; April 1998.
  Medical School/Hospital Administration  
 
2001
 "Innovative Technologies for Academic Health Centers." Given twice to: The Health System Executive Committee and The Information Technology Strategic Advisory Committee (ITSAC).
 
2001
 "Life Sciences and Bioinformatics Activities in Michigan: Overview and Strategic Considerations." Invited Presentation to the UM Health System CIO Executive Committee.
  High School Student Mentoring  
 
1998-1999
 K.K. Pandya (Green Hills School; Ann Arbor, MI)
 
2001
 B. Root (Pioneer High School; Ann Arbor, MI)
 
2001
 D. Welsh (Huron High School; Ann Arbor, MI)
  Undergraduate Student Mentoring  
 
1991-1993
 A. Chien (Department of Physics; with J.M. Weinberg)
 
1998-1999
 J. Dixon (Gallaudet University Fellow)
  UG & Graduate Student Group Mentoring  
 
2001
 UM Chapter Leader for Student Pugwash International: http://www.igc.org/pugwash/
With support from UM Life Sciences Society and Values Program.
  Masters Student Mentoring  
 
1993-1994
 A.B. Mackersie (M.S., EECS; with D.J. Anderson)
 
1994-1995
 P. Ray (MLS, School of Information and Library Studies; with M. Pao and A.J. Warner)
 
1994-1995
 P.V. Ketty (M.S., EECS; with D.J. Anderson)
 
1995-1996
 J.S. Glick (M.F.A., Medical Illustration; with J.L. Lillie)
 
1995-1996
 J. Chung (MSI, School of Information; Miranda Lee Pao Medical Informatics Student Fellowship; with A.J. Warner)
 
1995-1996
 J. Williams (MSI, School of Information; Digital Information Associate Fellow; with A.J. Warner)
 
1995-1996
 G. Hsu (M.S., Physiology)
 
1995-1997
 H. Fogel (M.S., Biological Sciences)
 
1996
 M.A. Nolte (MSI, School of Information; with A.J. Warner)
 
1996
 P.McClay (MSI, School of Information; with A.J. Warner)
 
2001-2003
 G. Durka-Pelok (M.S., Information Sciences; with T. Weymouth)
 
Doctoral Student Mentoring
  
 
1992-1993
 D.-Y. Shieu (Ph.D., EECS; D.J. Anderson, Chair; B.D. Athey, Cognate Member)
 
1998-2000
 B.S. Hoover (Ph.D., EECS; E.N. Leith, Chair; B.D. Athey, Cognate Member)
 
1998-2003
 K.D. Mills (Ph.D. Candidate, EECS; E.N. Leith, Chair; B.D. Athey, Cognate Member)
 
2000-2003
 N. Sowapotowak (Ph.D. Candidate, EECS; J. Fessler, Chair; B.D. Athey, Cognate Member)
 
1999-
 D. Wagner (Ph.D. Candidate, EECS; F. Jahanain, Chair; B.D. Athey, Cognate Member)
 
2001-2003
 A. Zimmerman (Ph.D. Candidate, School of Information, M. Hedstrom, Chair; B.D. Athey, Cognate Member)
 
2001-
 T.J. Hacker (Ph.D. Pre-Candidate, EECS; B. Nobel, Co-chair; B.D. Athey, Co-chair)
 
2001-
 W.-Y. Lee (Ph.D. Pre-Candidate, School of Education; C. Berger, Chair; B.D. Athey, Cognate Member)
 
2003-
 J. Han (Ph.D. Pre-Candidate, EECS; F. Jahanian, Chair; B.D. Athey, Cognate Member)
 
2003-
 S. Subramanian (Ph.D., Bioinformatics)
  Post-Doctoral Scholar Mentoring  
 
1992
 Dr. Gopal Avinash (Ph.D., Bioengineering, University of Michigan; with A.L. Nuttal)
 
1993-1994
 Dr. Christine Viguie (Ph.D., Biophysics; University of California, Berkeley)
 
1994-1995
 Dr. G.D. Guttmann (Ph.D., Biophysics; University of California–Berkeley)
 
1999-2002
 Dr. Inhan Lee (Ph.D., Biophysics, Korean National University; with J.R. Baker, Jr.)
 
2002-
 Dr. Andrew Boyd MD
 
Visiting Faculty Collaborators
  
 
1994
 G.J. Brakenhoff, Ph.D. (Professor, University of Amsterdam)
 
1996
 C.E. Schutt, Ph.D. (Professor, Department of Chemistry, Princeton University)
 
1997
 A.J. Warner, Ph.D. (Associate Professor, University of Michigan, School of Information)
 
2002
 Bradford Orr, Ph.D. (Professor, Department of Physics, University of Michigan)
 
2002-
 Donald R. Hilbelink, Ph.D. (Professor, Department of Anatomy, University of South Florida)
  ^back to top  
  Extramural Invited Presentations
 
1992
"Envisioning Information." Invited participant in the Prairie Festival, The Land Institute, Salnia, KS; May 1992.
 
1993
"A Systems Approach to Visualizing Confocal Microscopy Data in Three Dimensions." Department of Biomedical Engineering, University of California, San Diego (UCSD). March 1993.
 
1994
Invited Presentation: "A Networked Computer System to Visualize Reconstructed Embryos in Three Dimensions." NICHD Workshop on Computer-Assisted Embryo Imaging. National Institutes of Health (NIH). May 1994.
 
1995
Invited Presentation: "A Modern Imaging Collaboratory for Anatomy." FASEB meeting, Atlanta, GA. May 1995.
 
1995
Invited Presentation: "Using the Visible Human as an Image Database Locator." National Library of Medicine (NLM) First Annual Conference on the Visible Human. October 1996.
 
1996
Invited Presentation: "Tissue Imaging." Defense Science Research Council (DSRC). November 1996.
 
1996
"Semi-Automated Electron Microscopy Service for Pathology." Guest Faculty Member/Plenary Lecturer, First Annual Conference on Anatomic Pathology Informatics, Imaging, and the Internet. University of Pittsburgh Medical Center. November 1996.
 
1996
Invited Presentation: "Visualizing the Patten Embryological Collection." National Institute of Child Health and Development (NICHD), NIH. October 1997.
 
1998
Invited Presentation: "The Visible Human Female WWW Browser and the Next Generation Internet (NGI)." 2nd Visible Human Conference, Bethesda, MD; October 1998.
 
1998
Invited Presentation: "A Virtual Reality System for Human Gross Anatomy Instruction." Medicine Meets Virtual Reality 7; San Francisco, CA; January 1999.
 
1999
 Invited Presentation: "NGI Delivery of Visible Human Data in Support of Anatomy Training." Pittsburgh Supercomputing Center (PSC) Speaker Series; Carnegie Mellon University (CMU); Pittsburgh, PA; April 1999.
 
1999
 Invited Presentation: "Nanoscale Platforms for Therapeutic Delivery." Defense Sciences Research Council (DSRC), September 1999.
 
1999
 Invited Presentation: "High Performance Landmark
Driven Navigation of the Visible Human."AIPR, Cosmos Club, Washington, D.C.; October 1999.
 
2000
 Invited Presentation: "Visualization and Manipulation of Visible Human Datasets Using the Next Generation Internet (Internet2)." Metropolitan Washington Computer Assisted Surgery Society (WASHCAS). March 2000.
 
2000
 Invited Presentation and Demonstration: NASA Gigabit Networking Conference. "The University of Michigan Visible Human over the NGI." Presentation and Demonstration with T.J. Hacker.
June 2000.
http://www.nren.nasa.gov/gn_report.html
 
2000
 Invited Presentation: "Postmodern Anatomy and its Enabling Technologies." First Annual Digital Human Workshop, National Library of Medicine (NLM).
 
2000
 "Visible Human Project Distributed Visualization." with T.J. Hacker. NGI/NREN Workshop V, "Gigabit Networking: The End-to-End View." NASA Ames Research Center, Moffett Field, CA;
August 14-16, 2000.
 
2000
 Invited Presentations: "Directed Nano-Dendrimeric Modeling and Simulation." Talk given 3 times: 1) National Cancer Institute (NCI) Unconventional Innovations Program (UIP) PI Meeting; 2) The Midwest Clinical Society (Chicago, IL.), and 3) the BioMEMS and Biomedical Nanotechnology 2000 Conference, Columbus, OH; October 2000.
 
2000
 Keynote Address: "21st Century Pathology Informatics and Integration into the Emerging Hospital Information System." American College of Pathology (ACP), San Diego, CA;
October 2000.
 
2000
 Invited Presentation: "How to Move from Static to Something Moving End-to-End or The How? And Why? Of Infrastructure." Internet2 National Meeting, Washington, DC; April 2001.
 
2001
 Invited Presentation: "Grid Computing Solutions for the Physical and Life Sciences." SC2001 Sun HPC Consortium, Denver, CO;
Nov. 11, 2001.
 
2001
 Invited Presentation: "A Methodology for Account Management in Grid Computing Environments." SC2001 Grid 2001 Workshop, Denver CO; November 12, 2001.
 
2001
 Invited Presentation: "Application Responsibilities in End-to-End Network Performance." SC2001 Internet3 End-to-End Performance Workshop, Denver CO; November 15, 2001.
 
2001
 Invited Presentation: "Maximizing End-to-End Network Performance." High Energy/Nuclear Physics (HENP) Internet2 Working Group, Ann Arbor, MI; October 5, 2001.
 
2001
 Invited Presentation: International Conference on Virtual Worlds and Simulation. "Deploying Scalable Information Infrastructure (SII) End-to-End: The Role of Middleware and Standards."
San Antonio, TX; January 27-31, 2002.
 
2002
 Invited Speaker: US Department of Defense (DoD) ASBREM off-year TARA review. "Deploying Scalable Information Infrastructure (SII) End-to-End: The role of Middleware and Standards." Baltimore, MD; February 13-14, 2002.
 
2002
 “Bioinformatics and IT Infrastructure for the Life Sciences.” Invited speaker. CIMIT and the Harvard/MIT HST Program. Boston, MA. July 16, 2002.
 
2002
 “Future Needs for Bioinformatics, Computational Biology, Bioengineering, and Biomedical Imaging Requiring Next Generation Supercomputing.” DARPA Biomedical Computing Needs for HPC Systems Workshop. Arlington, VA. January 17, 2003.
 
2002
 “Bioinformatics and Bioimaging IT Infrastructure: What is the MCBI and the CTA?” 1st Annual Conference of Pathology Bioinformatics, University of Michigan. November 13, 2002.
 
2002
 “The Visible Human Today.” iGrid 2002 Conference. Amsterdam, The Netherlands. September 26, 2002.
 
2003
 “Future Needs for Bioinformatics, Computational Biology, Bioengineering, and
Biomedical Imaging Requiring Next Generation Supercomputing.” DARPA Biomedical Computing Needs for HPC Systems Meeting.
Arlington, VA. January 17, 2003.
 
2003
 “Future Needs for Bioinformatics, Computational Biology, Bioengineering, and
Biomedical Imaging Requiring Next Generation BioGrids.” SURA Biogrid Workshop Research Triangle Park, NC. January 29, 2003.
 
^back to top
  
 
Other Presentations and Workshops
 
1994
 Visualizing 3-D Biological Structure Using the Confocal Microscope." Optical Society of America, Michigan Chapter,
Ann Arbor, MI.
 
1994
 "Confocal Microscopy of Tissues and Cells of Clinical Interest." Department of Biology, Oakland University; Rochester, MI.
 
1996
 "Medicine and Terabits." Presenter, University of Michigan College of Engineering/State of Michigan Joint Conference (with Wistra Institute/Republic of Germany) on Ultra Highspeed Optical Networks. October 1996.
 
1997
 "GIS and Medicine: New Frontiers." A half-day workshop organized by B.D. Athey and given to the University of Michigan research community. Funded by the University of Michigan Office of the Vice-President for Research (OVPR) and the Rackham School of Graduate Studies. March 1997.
 
1997
 "Multi- and Hyper-spectral Geo-sensing Capabilities Transferred to the Microscope and Mesoscope." Invited Speaker, First International Conference of Multispectral Microscopy. Warner-Lambert, Parke-Davis Research Division; June 1997.
 
1998-1999
 "Modeling of Biological Systems (MOBS)." Invited participant for course planning session. Woods Hole Marine Biological Laboratory (MBL). R. Silver, Course Director. Supported by the Burroughs Welcome Foundation. January and March 1998.
 
2001
 "Michigan's Emerging Position in the Global Information Infrastructure for the Life Sciences." Invited speaker, Van Andel Institute. March 2001.
 
2001
 "Michigan-Based Imaging Capabilities to respond to Terrorist Threats." Private briefing given to Senator Carl Levin, Chair - Senate Armed Services Committee. November 2001.
 
2002
 "Simplification and Diversity: An Ecosystem Mimic to the Rapid, Robust Scalable Information Infrastructure (SII) Deployment of CBNR Trauma Environments." Special seminar to Dr. Robert Foster, Director of Biosystems, DDR&E, Undersecretary of Defense for S&T. April 2002.
 
2002
 "How to Avoid Spaghetti While Scaling Just-in-Time Training Capabilities." NASA/MITAC Conference on Just-in-Time Training in Medicine. Virginia Commonwealth University. May 13, 2002.
 
2002
 "The Michigan Center for Biological Information (MCBI)." Invited Speaker, Michigan Life Sciences Corridor Biotechnology Symposium, Lansing MI. May 14, 2002.
 
2002
 “Experiences Using Web100 for Visible Human Testbeds.” Web100 Evaluator’s
Workshop, Boulder CO. Aug. 1, 2002.
 
2003
 2003 “Future Needs for Bioinformatics, Computational Biology, Bioengineering, and Biomedical Imaging Requiring Next Generation Supercomputing.” Invited Speaker. DARPA High Productivity Computing Systems Workshop, Arlington, VA. Jan 16, 2003.
  ^back to top  
 
Committee and Administrative Service
 
International
  
 
2000
 Biological Weapons Working Group (BWWG), Federation of American Scientists (FAS). Active participant on the FAS Biological Weapons and Toxin Convention (BWTC) treaty negotiation team - an NGO representative to the Geneva Convention.
http://www.fas.org/faspir/v53n5.htm
 
National
  
 
1998
 Invited member, special advisory panel to the National Institute for Dental Research (NIDR) to formulate a plan for an internet-based head and neck anatomy atlas. Organized by the American Association of Anatomists (AAA).
http://www.nidr.nih.gov/news/strat-plan/headneck.htm
 
2000
 Discipline Co-leader - Health Sciences Editorial Board for Multimedia Educational Resources for Learning and Online Teaching (MERLOT).
http://taste.merlot.org/App01-02.html
 
University
  
 
1997-1999
 Media Union Virtual Reality Committee
 
2000-2001
 Member, The University of Michigan Presidential Information Revolution Commission (PIRC), (Infrastructure Subcommittee, Research Subcommittee).
http://www.umich.edu/pres/inforev/
 
2000
 IBM/The University of Michigan Life Sciences Liaison
 
2001
 “MGRID” Michigan Center for Infrastructure Research and Development
Co-Founder and Board Member.
 
Medical School/Hospital
  
 
1992
 Fellowship Selection Committee, Chemical and Hearing Senses Training Grant, Kresge Hearing Research Institute (KHRI).
 
1997-1999
 Medical School Faculty Information Technology Committee (FITC).
 
1998-1999
 Diagnostic Imaging Advisory Committee (DIAC), MCIT.
 
2000-
 Information Technology Advisory Committee (ITAC).
 
Department
  
 
1995-2001
 Cell Biology Lab (CBL)/Microcopy Imaging Laboratory (MIL) Committee.
 
1999-
 Anatomy Teaching Laboratory Committee
 
^back to top
  
  Patents
 
1999
 Patent Disclosure, USPTO: "Dynamic Brace to Relieve Carpal Tunnel Syndrome."
 
^back to top
  
 
Bibliography
 
Peer-Reviewed Publications
  
 
1.
 Williams, S.P., B.D. Athey, L.J. Muglia, R.S. Schappe, A.H. Gough and J.P. Langmore. 1986. "Chromatin Fibers are Left-Handed Double Helices with Diameter and Mass Per Unit Length that Depend on Linker Length."
Biophys. J. 49:233-248. (Plenary presentation for the 1985 Biophysical Discussions entitled "Macromolecular Assembly Analyzed by Converging Structural Techniques").
 
2.
 Smith, M.F., B.D. Athey, S.P. Williams and J.P. Langmore. 1990. "Radial Density Distribution of Chromatin: Evidence that Chromatin Fibers Have Solid Cores." J. Cell Biol. 110:245-254.
 
3.
 Athey, B.D., M.F. Smith, D.A. Rankert, S.P. Williams and J.P. Langmore. 1990. "The Diameters of Frozen-Hydrated Chromatin Fibers Increase with DNA Linker Length: Evidence in Support of Variable Diameter Models for Chromatin." J. Cell Biol. 111:795- 806.
 
4.
 Grober, J.S., B.L. Bowen, H. Ebling, B.D. Athey, C. Thompson, D.A. Fox and L.M. Stoolman. 1993. "Monocyte-Endothelial Adhesion in Chronic Rheumatoid Arthritis. In Situ Detection of Selectin and Integrin-Dependent Interactions." J. Clin. Invest. 91:2609-2619.
 
5.
 Rapha el, Y.R., B.D. Athey, Y. Wang, and J.E. Hawkins. 1993. "Reticular Lamina Structure and Repair after Noise Injury." Revue de Laryngologie Otologie Rhinologie. 114(3):171-175.
 
6.
 Shieu, D-Y., B.D. Athey, and D.J. Anderson. 1994. "An Efficient Surface Rendering Technique Using Fourier Descriptors to Visualize
Three-Dimensional Biomedical Image Data Sets." Accepted paper to IEEE signal processing.
 
7.
 Raphael, Y., B. D. Athey, Y. Wang, M.K. Lee and R.A. Altschuler. 1994. "F-actin and Spectrin in the Organ of Corti: Comparative Distribution in Different Cell Types and Mammalian Species." Hearing Res. 76(1-2):
173-187.
 
8.
 Nurko, S., K. Sogabe, J.A. Davis, N.F. Roeser, M. Defrain, A. Chien, D. Hinshaw, B.D. Athey, W. Meixner, M.A. Venkatachalam and J.M. Weinberg. 1994. "Contribution of Actin Cytoskeleton Alterations to ATP Depletion and Calcium-Induced, Rabbit Proximal Tubule Cell Injury." American Journal of Physiology, F39-F52.
 
9.
 Brakenhoff, G.J., J. Squier, T. Norris, A. Blitoz, M.H. Wade and B.D. Athey. 1996. "Realtime Two-Photon Confocal Microscopy Using a Femtosecond, Amplified Ti: Sapphire System." Journal of Microscopy, 181:253-259.
 
10.
 Athey, B.D., A.J. Warner, J.C. Laby, W.M. Meixner, J. Chung and J.P. Williams, 1996. "Using the Visible Human as an Image Database Locator." The 1st National Library of Medicine (NLM) Conference on the Visible Human. (peer-reviewed electronic publication).
 
11.
 Ade, A.S., W. Meixner, and B.D. Athey, 1998. "The Visible Human Female WWW Browser and the Next Generation Internet (NGI)." The 2nd National Library of Medicine (NLM) Conference on the Visible Human.
 
12.
 Clark, H.A., K. Kopelman, B.D. Athey, A.S. Ade, W.M. Meixner, D. Hill, R. Lightle, M. Hoyer and M.A. Philbert. 1998. "Subcellular Optochemical Nanobiosensors: Probes Encapsulated By Biologically Localized Embedding (PEBBLES)." Sensors and Actuators B, Chemical. 51, 12-16.
 
13.
 Athey, B.D., F. Bookstein, A. Ade, M.W. Meixner, and A. Wetzel. 1999. "High Performance Landmark Driven Navigation of the Visible Human", Vol. 3905, SPIE Proceedings, invited paper.
 
14.
 Ade, A.S., F.L. Bookstein, and B.D. Athey, 2000. "The University of Michigan Next Generation Internet Implementation to Serve Visible Human Datasets." The 3rd National Library of Medicine (NLM) Conference on the Visible Human. http://vhp.med.umich.edu/ADE.HTM
(peer-reviewed electronic publication).
 
15.
 Wetzel, A.W., Ade, A., Bookstein, F.L., Green, W., B.D. Athey, 2000. "Representation and Performance Issues in Navigating Visible Human Datasets". The 3rd National Library of Medicine (NLM) Conference on the Visible Human. (peer-reviewed electronic publication).
 
16.
 Bookstein, F.L., B.D. Athey, W.D. Green, A.W. Wetzel. 2000. "Navigating Solid Medical Images by Pencils of Sectioning Planes." Proceedings of SPIE Vol. 4121 pp. 117-127.
 
17.
 Hacker, T.J., B.D. Athey. "Account Allocations on the Grid." First Global Grid Forum & European Datagrid Conference, Account Models Research Group. 2001. pp. 1-14.
 
18.
 G. Higgins, B.D. Athey, Bassingthwaighte J., Burgess J., Champion H., Cleary K., Dev P., Duncan J., Hopmeier M., Jenkins D., Johnson C., Kelly H., Leitch R., Lorensen W., Metaxas D., Spitzer V., Vaidehi N., Vosburgh K., Winslow R. "Modeling & Simulation in Medicine: Towards an Integrated Framework." Comput. Aided Surg. 2001;6(1):32-9.
 
19.
 Mills, K.D., L. Deslaurier, D.S. Dilworth, S.M. Grannell, B.G. Hoover, B.D. Athey, E.N. Leith. 2001. "Investigation of Ultrafast Time Gating by Spatial Filtering." Applied Optics 40, 2282-2289.
 
20.
 Leith, E.N., K.D. Mills, L. Deslaurier, S.M. Grannell, B.G. Hoover, S.S. Dilworth, H. Chen, M. Shih, J Lopez, and B.D. Athey. 2001. "Information Optics Concept Applied to Image Formation in Highly Scattering Media." SPIE Lohman Memorial Paper.
 
21.
 Hacker, T.J., B.D. Athey, "Observation Based External Assessments for Grid Computing Environments," Global Grid Forum Accounting Models Research Group working draft. Presented at 3rd Global Grid Forum Accounting Models Research Group, October, 10, 2001, Frascati, Italy.
 
22.
 Hacker, T.J., B.D. Athey, "A Methodology for Account Management in Grid Computing Environments," Proceedings of the 2nd International Workshop on Grid Computing, November 2001, Denver Colorado, Lecture Notes in Computer Science, pp. 133-144. Springer Verlag Press.
 
23.
 Hacker, T.J., B.D. Athey, "The End-to-End Performance Effects of Parallel TCP Sockets on a Lossy Wide-Area Network," IEEE-CS/ACM International Parallel and Distributed Processing Symposium (IPDPS) April 2002.
 
24.
 Inhan Lee, B.D. Athey, J.R. Baker, et al. 2002. "Structural Molecular Dynamic Studies on Therapeutically-Applied Polyamidoamine Dendrimers: The Effects of pH and Surface Derivatization Group," Macromolecules, 35(11), 4510-4520.
 
25.
 Hoover BG, Deslauriers L, Grannell SM, Ahmed RE, Dilworth DS, Athey B.D., Leith EN. "Correlations Among Angular Wave Component Amplitudes in Elastic Multiple-scattering Random Media." Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Feb;65(2 Pt 2):026614.
 
26.
 Leith EN, Mills KD, Grannell S, Dilworth DS, Athey B.D., Lopez J. "Analysis of Time-gated Imaging through Scattering Media by a Fourier Optics Approach." J. Opt. Soc. Am. A, Opt Image Sci Vis. March 2002.
19(3):532-6.
 
27.
 Walker, D.S., W.Y. Lee, N. Skov, C. Berger, and B.D. Athey. 2002. "Investigating User Requirements: Computer-based Anatomy Learning Modules for Multiple User Test-beds." Submitted to the Journal of the American Medical Informatics Association (JAMIA).
(accepted for July 2002 issue)
 
28.
 Thigpen, B., Hacker, T., McGinnis, L., Athey, B.D. "Distributed Accounting on the Grid." Proceedings of the 6th Joint Conference on Information Sciences (JCIS), 2002.
 
29.
 Hacker, T.J., B. Noble and B.D. Athey. “The Effects of Systemic Packet Loss on Aggregate TCP Flows.” Proceedings of Supercomputing 2002, November 2002.
 
30.
 Leith, E.N., W.C. Chien, K.D. Mills, B.D. Athey and D.S. Dilworth. 2003. “Optical Sectioning by Holographic Coherence Imaging: A Generalized Analysis.” Optical Society of America, 20(2):380-387.
 
31.
 Singh, G.B., H. Song, D. Liu, D. Wildman, M. Goodman, C. Bliton, G. Kostov, B. D. Athey.
2003. “ A Non-Homology Method for Sensitive Information Retrieval from Biological
Databases.” Proceedings of the 7th Joint Conference on Information Sciences.
 
32.
 Boyd, A.D., DiFranco, D.J., B.D. Athey. 2004. “Challenges of HIPAA Regulations in
Academic Biomedical Research.” MEDINFO 2004.
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  Abstracts and Preliminary Communications  
 
1.
 Athey, B.D. and J.P. Langmore. 1984. "Simplified Transfer of
Frozen-Hydrated Specimens into a Commercially Available Cooling Holder." 42th Ann. Proc. EMSA, G.W. Bailey, editor. 170-171.
 
2.
 Athey, B.D., S.P. Williams, and J.P. Langmore. 1985. "Chromatin Fibers are Left-Handed Helices with Mass per Unit Length Dependent on Linker Length." J. Cell. Biol. 101:2a. (First publication and description of the double helical crossed-linker model).
 
3.
 Williams, S.P., B.D. Athey and J.P. Langmore. 1985. "Chromatin Fiber Diameter is Proportional to Linker Length." J. Cell. Biol. 101:755a.
 
4.
 Williams, S.P., B.D. Athey and J.P. Langmore. 1985. "The Crossed-Linker Double Helical Model for Chromatin." Biophys. J. 49:224a.
 
5.
 Athey, B.D., S.P. Williams and J.P. Langmore. 1986. "The Crossed-Linker Double Helical Model for Chromatin." Invited Paper, Regional Meeting of the ACS, Bowling Green, OH, June 1986.
 
6.
 Langmore, J.P. and B.D. Athey. 1987. "Removal of Inelastically Scattered Electrons Substantially Increases Phase Contrast on Frozen-Hydrated Molecules." 45th Ann. Proc. EMSA, G.W. Bailey, editor. 652-653.
 
7.
 Athey, B.D., J.P. Langmore, S.P. Williams, M.F. Smith, R. Grant and W. Chiu. 1987. "Cryo-Electron Microscopy of Chromosome Fibers is Consistent with the Crossed-Linker Model for Chromatin Structure." 45th Ann. Proc. EMSA, G.W. Bailey, editor. 648-649.
 
8.
 Athey, B.D., A.L. Stout, M.F. Smith and J.P. Langmore. 1988. "Quantitative Diameter Measurements of Chromatin and TMV Fibers in the Freeze-Dried State." 46th Ann. Proc. EMSA, G.W. Bailey, editor. 170-171.
 
9.
 Langmore, J.P., M.F. Smith, D.A. Rankert, S.P. Williams and B.D. Athey. 1988. "Cryo-Electron Microscopy of Chromosome Fibers." J. Cell Biol. 107:313a.
 
10.
 Kim, D., L. Wu, M. Su, B.D. Athey and P. B. Kaufman. 1992. "pH Plays a Role in the Gravitropic Response of Leaf Shoot Pulvini of Oats." In Proceedings of the International Conference Gravitropic Response, Tucson, AZ. Mark Tischler, Editor.
 
11.
 Raphael, Y.R., B.D. Athey, Y. Wang and J.E. Hawkins. 1992. "Reticular Lamina Structure and Repair after Noise Injury." Revue de Laryngologie Otologie Rhinologie. Veronique Lombard, Editor. Presented, Oct. 1992.
 
12.
 Avinash, G., B.D. Athey, D-Y. Shieu, M.W. Meixner, D.J. Anderson, R.A. Altschuler and A.L. Nuttal. 1992. "The Use of Computational Deblurring Techniques to Enhance the Resolution of Confocal Data Sets from Organ of Corti Surface Preparations." Sixteenth Midwinter Meeting ARO: 117.
 
13.
 Athey, B. D., Y. Raphael, W. M. Meixner, D-Y. Shieu, Y. Wang, D. J. Anderson and R. A. Altschuler. 1993. "Three-Dimensional Visualization of F-actin in the Lateral Wall of Outer Hair Cells Using Confocal Microscopy." Sixteenth Midwinter Meeting ARO: 117.
 
14.
 Viguie, C.A. and B.D. Athey. 1993. "Three-Dimensional Visualization of Single Muscle Fibers: An Application of Laser Scanning Confocal Microscopy (LSCM)." The Anatomical Record: Supplement 1, ABS 337.
 
15.
 Athey, B.D., D.-Y. Shieu, C.A. Viguie, D.J. Anderson. 1994. "Efficient Surface Rendering Technique Utilizing Fourier Descriptors to Visualize 3-D Biomedical Image Data Sets." IS&T/SPIE Electronic Imaging Science and Technology, Conference #2184-26.
 
16.
 Brakenhoff, G.J., J. Squire, T. Norris, C. Bliton and B.D. Athey. 1994. "Realtime 2-Photon Confocal Microscopy Using a Femtosecond, Amplified Ti:Sapphire System." International Conferences on Confocal and Nearfield Microscopy: Munchen, Germany.
 
17.
 Squier, J., T. Norris, C. Bliton, G.J. Brakenhoff and B.D. Athey. 1994. "Realtime 2-Photon Confocal Microscopy Using a Femtosecond, Amplified Ti:Sapphire System." Ultrafast Phenomena IX, edited by P. F. Barbara, W. H. Knox, G. A. Mourou, and A. H. Zewail (Springer-Verlag, New York, 1994), pp. 136-138.
 
18.
 Warner, A.J., B.D. Athey, M. Pao, W.B. Panko and J. Holden. 1994. "A Network-Based Image Repository for Biomedical Researchers." 18th Annual Symposium on Computer Applications in Medical Care (SCAMC).
 
19.
 Fogel, H., B.D. Athey, W.M. Meixner, A.S. Ade, J.C. Laby, J. Glick. 1997. "Three-Dimensional Visualization of the Dorsal Vessel of Drosophila Melanogaster." First International Symposium on Molecular Control of Organogenesis, October 1996.
 
20.
 Warner, A.J., B.D. Athey, J. Chung, J.P. Williams. "Experiential Learning in Specific Applications: The Applications Area Component at the University of Michigan." ALISE, 1997.
 
21.
 Eichman Jonathan D., Kukowska-Latallo Jolanta F., Chen Chunling, Meixner Walter, Athey Brian D., and Baker James R., Jr. "Effects of a Non-Ionic Surfactant on Polymer Mediated Transfection." AAPS national meeting, San Francisco, CA, November 1998.
 
22.
 A.S. Ade, W. Meixner, and B.D. Athey. 1999. "A Virtual Reality System for Human Gross Anatomy Instruction." Medicine Meets Virtual Reality (MMVR) 7.
 
23.
 A Wetzel and B.D. Athey. 2000. "Networked Delivery of Visible Human Datasets." NLAR/Internet2 Techs Meeting. http://www.healthtech.com/conference/00mem/.
 
24.
 I. Lee, B.D. Athey, A. W. Wetzel, A. Kar, J. Eichman, W. Meixner, and James R. Baker, Jr. 2000. "Directed Nanomolecular Modeling and Simulation
of Targeting, Sensing, and Therapeutic Functionalities has Enabled Rapid Demonstration and Prototyping." Principal Investigators Meeting, NCI Unconventional Innovations Program, June 28-29, 2000. Presenter: B.D. Athey.
http://otir.nci.nih.gov/cgi-%20">http://otir.nci.nih.gov/cgi-
 
25.
 Bookstein F.L., B.D. Athey, W. D. K. Green, University of Michigan, A. Wetzel, Pittsburgh Supercomputing Center. "Navigating Solid Medical Images by Pencils of sectioning Planes." Mathematical Methods of Medical Imaging, SPIE Annual Meeting, San Diego, CA. August 2000.
 
26.
 Athey, B.D., 2000. "Directed Nano-Dendrimeric Modeling and Simulation". BioMEMS and Biomedical Nanotechnology 2000 Conference, Columbus, OH.
Oct. 2000. http://www.healthtech.com/conference/00mem/
 
27.
 I. Lee, I. Majoros, B. D. Athey, D.A. Tomalia, J.R. Baker, Jr., 2000. "Structural Characterization of an Amine-terminated Hybrid Dendrimer: Molecular Dynamics Studies". Eighth Foresight Conference on Molecular Nanotechnology. http://www.foresight.org/Conferences/MNT8/Abstracts/Baker/index.html
 
28.
 Athey, B.D., "How to Move from Static to Something Moving End-to-End or The How? And Why? Of Infrastructure." Western MultiConference Proceedings. The Society for Computer Simulation International. January 2001. http://www.cs.umd.edu/~cal/VWsim/schedule-vwsim01.html
 
29.
 Durka-Pelok, G., S. Pomerantz, C. Gadd, T. Weymouth, T. Gest, J. Huang, D. Nave, A. Wetzel, W.Y. Lee and B.D. Athey 2002. “Evaluation of a Volume Browser: PSC-VB.” 4th Visible Human Conference, Keystone, CO.
 
30.
 Durka-Pelok, G., T. Gest, G. Nieder, T. Weymouth, J. Huang, A. Wetzel, S. Pomerantz, D. Nave and B.D. Athey. 2002. “Creation of an Educational Visual Module: Integration of QTVR and the Visible Human Data Set.” 4th Visible Human Conference, Keystone, CO.
 
31.
 Durka-Pelok, G., T. Weymouth, T. Gest, S. Pomerantz, D. Nave, A. Wetzel, W.Y. Lee and B.D. Athey. 2002. “Bookmarking the Visible Human Dataset.” 4th Visible Human Conference, Keystone, CO.
 
32.
 Weymouth, T., G. Durka-Pelok, T. Gest, J. Huang, S. Pomerantz, A. Wetzel, C. Berger and B.D. Athey. 2002. “Using a Knowledge Base: The University of Michigan Visible Human Project.” 4th Visible Human Conference, Keystone, CO.
 
33.
 Walker, D., W.Y. Lee, N. Skov, C. Berger and B.D. Athey. 2002. “Investigating User Requirements: Design of Computer-based Anatomy Learning Modules for Multiple User Groups.” 4th Visible Human Conference, Keystone, CO.
 
34.
 Hacker, T.J., B.D. Athey and J. Sommerfield. 2002. “Experiences Using Web100 for End- To-End Network Performance Tuning.” 4th Visible Human Conference, Keystone, CO.
 
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  Other Support
  Active  
   

2 R01 AI 37141 (Baker, James R. Jr.)                         05/01/04 - 04/30/09                   0.00 calendar
NIH / NIAID
Apoptosis in Thyroiditis. Role: Co-I

The major goal of this effort is to provide bioinformatics support for Dr. Baker’s project.
Role: Co-I

     
   

1 U54 DA021519-01A1 (Athey, Brian D.)                         09/25/05 - 08/31/10           4.20 calendar
NIH
National Center for Integrative Biomedical Informatics (NCIBI)

This is one of the seven NIH National Centers for Biomedical Computing (NCBC). Focus is biomedical informatics data integration and modeling, including advanced biomedical Information Retrieval (IR).
Role: PI
     
   

1 UL1 RR024986 (D. Clauw PI)                         9/17/07 – 5/31/12                          2.4 calendar mo
NIH / NCRR                                                                                     &n