Index | Caspase | CARD/DED/BIR | Bcl-2 | DD | TNF/TNFR | Kinases | ILs | Viral | Lipid | Engulf | TF | RING | Toll | Other Apop | Other NFkB | Alphabet |
Further impact factors for apoptosis and NF-kB.
(NOTE: This is NOT a main index home page. ).
Family | Name | specices | apoptosis | NF-kB | KO | structure | 3D | locus | upstream regulators | binding factors | memos |
WNT | Wnt1 | human | inhibit | induce | Wnt | 12q12-q13 | PEA3, NF-kB, CD9 | targets | |||
Wnt2 | human | Wnt | 7q31 | ||||||||
Wnt2b, Wnt13 | human | Wnt | 1p13 | Nef,
CD9 |
|||||||
Wnt3 | human | Wnt | 17q21 | ||||||||
Wnt3a, Wnt14 | human | related? | L | Wnt | 1q42 | RA | targets | ||||
Wnt4 | human | Wnt | 1p36.23-p35.1 | A2aR,
Pg |
|||||||
Wnt5a | human | Wnt | 3p21-p14 | estrogen,
LPS,
UVB,
CD9,
IL13 |
|||||||
Wnt5b | human | Wnt | 12p13.3 | Subst.P | |||||||
Wnt6 | human | Wnt | 2q35 | ||||||||
Wnt7a | human | Wnt | 3p25 | TNFa, TTF-1, GATA6, Foxa2, Subst.P, estrogen | |||||||
Wnt7b | human | Wnt | 22q13 | TNFa,
ARNT2
|
|||||||
Wnt8a | human | 5q31 | |||||||||
Wnt8b | human | Wnt | 10q24 | ||||||||
Wnt10a | human | Wnt | 2q35 | Subst.P | |||||||
Wnt10b | human | Wnt | 12q13 | ||||||||
Wnt11 | human | Wnt | 11q13.5 | ||||||||
Wnt15, Wnt9b | human | Wnt | 17q21 | |
|||||||
Wnt16 | human | Wnt | 7q31 | ||||||||
Dickkopf | DKK-1(Dickkopf-1) | human | enhance | DKK | 10q11.2 | Bmp4,
EWS/FLI-1,
p53,
UV,
c-Jun,
Ye |
LRP5, LRP6, Kremen1, Kremen2 | anti-Wnt | |||
DKK-2 | human | DKK | 4q25 | CREB | LRP5, LRP6, | ||||||
DKK-3 | human | DKK | 11p15.3 | EWS/FLI-1 | |||||||
DKK-4 | human | DKK | 8p11.2-11.1 | ||||||||
LRP | LRP5 | human | 1 | (LDLRbx5/EGF)x4/LDLRax3/TM | 11q13.4 | ||||||
LRP6 | human | 1 | (LDLRbx5/EGF)x4/LDLRax3/TM | 12p11-p13 | DKK1,DKK2 | ||||||
Kremen | Kremen1 | human | kringle/WSC/CUB/TM | 22q12.1 | DKK | ||||||
Kremen2 | human | kringle/WSC/CUB/TM | 16p13.3 | DKK | |||||||
Frizzled | Fzd1 | human |
|
Fz/7TM | 7q21 | estrogen | anti-Wnt | ||||
Fzd2 | human |
|
Fz/7TM | 17q21.1 | Hoxc8, Wnt-1, RA | ||||||
Fzd3 | human | Fz/7TM | 1 | 8p21 | |||||||
Fzd4 | human | Fz/7TM | 11q14-q21 | PTH | |||||||
Fzd5 | human | Fz/7TM | 2q33-q34 | ||||||||
Fzd6 | human | Fz/7TM | 8q22.3-q23.1 | ||||||||
Fzd7 | human | Fz/7TM | 2q33 | IL10,
Stat4b,
b-catenin |
|||||||
Fzd8 | human | Fz/7TM | 1 | 10p11.21 | AdV | ||||||
Fzd9 | human | Fz/7TM | 7q11.23 | Subst.P, LPS | |||||||
Fzdz10 | human | Fz/7TM | 12q24.33 | ||||||||
SARP1, SFRP2 | human, mouse | protect | Fz/NTR | 4q31.3 | estrogen | ||||||
SARP2, FRP, SFRP1 | human | sensitize | Fz/NTR | 8p12-p11.1 | DAC/TSA,
PRX2 |
||||||
SFRP3, FRP3, FRZB | human, mouse | related? | Fz/NTR | 2qter | PRX2 | ||||||
SARP3/SFRP5 | human | related? | Fz/NTR | 10q24.1 | |||||||
SFRP4/frpHE | human | Fz/NTR | 7p14.1 | ||||||||
MFRP | human | TM/CUB/LDLa/CUB/LDLa/Fz | 11q23 | ||||||||
carboxypepdase Z, CPZ | human | Fz/carboxypeptidase | 4p16.1 | ||||||||
armadillo | APC | human, mouse, rat, Xenopus, D.m., Urechis, C.e.(K04G2.8) |
|
L | cc/cc/Ser-rich/DE-rich armadillox8/SAMP rpt |
L | 5q21-q22 | c-Myc, p53, USF1, USF2 | casp | ||
APC2, APCL | human, Dm | 19p13.3 | |||||||||
beta-catenin | human, mouse, rat, Xenopus, sea urchin, |
|
1 | armadillox12 | L | 3p21 | NF-IL6,
TGFb,
FSH |
APC, a-cat., Tcf, Lef | casp,in
bcl-2
KO, targets |
||
gamma-catenin, junction plakoglobin, JUP | human | armadillox11 | 1 | 17q21 | |||||||
delta2-catenin | human | cc/armadillox9 | 5p15.2 | Erbin | |||||||
ARVCF | human | cc/armadillox7 | 22q11 | Erbin | |||||||
plakophilin | human | 2q23-q31 | |||||||||
armadillo | D.m., house fly, spoonworm | ||||||||||
RGS | axin 1 | human, mouse, rat, chicken |
|
RGS/cc/GSKBD-bBD/dishevelled | L | 16p13.3 | E2F1 | PIASs | SUMO | ||
axin 2/axil,/conductin | human, mouse, rat | RGS/cc/DAX/dishevelled | 17q23-q24 | TNFa, TCF, b-cat, estrogen | |||||||
RGS1, IER1 |
human, mouse | RGS | 1q31 | IL2, PMA | |||||||
RGS2 | human, mouse | RGS | L | 1q31 | AIRE, TNFa, PTH, CRF, LPS, Lm, YopP, A2aR, Blimp1 | Galpha | accelerate GTPase/inhibit signaling | ||||
RGS3 | human, mouse | induce(T) | PDZ/PH/RGS | 9q31-q33 | IL1,
TNFa,
IL13 |
||||||
RGS4 | human, mouse, rat | inhibit | 1 |
RGS | L | 1q23.1 | AP1, Brn3a, HCV | inhibit
MAPKs |
|||
RGS5 | human, mouse | RGS | 1q23.1 | PDGF,
VEGF,
IL1 |
|||||||
RGS6 | human, mouse | DEP/GGL/RGS | 14q24.3 | ||||||||
RGS7 | human, mouse | DEP/GGL/RGS | 1q43 | ||||||||
RGS8 | human, mouse, rat | RGS | 1q25 | ||||||||
RGS9 | human, mouse | 1 | GGL/RGS | L | 17q23-q24 | ||||||
RGS10 | human, mouse | GGL | 10q25 | Brn3a, ARNT2 | |||||||
RGS11 | human | DEP/GGL/RGS | 16p13.3 | ||||||||
RGS12 | human | PDZ/PTB/RGS/RBDx2/GoLoco | 4p16.3 | Cdx2 |
|||||||
RGS13 | human, mouse | RGS | 1q25.3 | ||||||||
RGS14 |
human |
5q35.3 |
TNFa | ||||||||
RGS16 | human | RGS | 1q25-q31 | NF-kB,
TNFa,
IKKs,
LPS,
IL10 |
|||||||
RGS17 | human | RGS | 6q25-q26 | ||||||||
RGS18 | human | RGS | 1q31.2 | ||||||||
RGS19, GAIP | human | RGS | 20q13.3 | ||||||||
RGS20, RGSZ1 | human | RGS | 8q12.1 | ||||||||
other RGS | F16H9.1(C.e.) etc | Dishevelled | |||||||||
NKD | naked cuticle, NKD1 | human, Dm | EF | 16q12 | Wingless | ||||||
Dishevelled | Dishevelled 1, DVL1 | human, rat,Dm., Xl, Ce (yk10b11.5, yk35a4.5, yk134c11.5, T05C12.6) |
|
N domain/DHR | L | 1p36 | Ld | MusK, Nkd, mtSOD1, NEDL1 | Ub | ||
Dishevelled 2, DVL2 | human, mouse, Xl, | 1 | 17p13.2 | ||||||||
Dishevelled 3, DVL3 | human, mouse, zebrafish, | 3q27 | |||||||||
DAAM1 | DAAM1 | human | cc/FH2 | 14q22.3 | FKHR | ||||||
DAAM2 | human | cc/FH2 | 6p21.1 | ||||||||
diaphanous 1, DIAPH1 | human | M/cc/FH2 | 5q31 | ||||||||
GSK | GSKbeta3 | see kinases | |||||||||
LEF-TCF | LEF-TCF | see TFs | |||||||||
CCN | WISP1 | human |
|
IB/VWC/TSP1/CT | 8q24.1-q24.3 | CREB,
Wnt1,
b-catenin,
CD9 |
binds to decorin, biglycan | ||||
WISP2 | human | IB/VWC/TSP1 | 20q12-q13.1 | Wnt1 | |||||||
WISP3 | human | IB/VWC/TSP1/CT | 6q22-q23 | CD9 | |||||||
CTGF | human | IB/VWC/TSP1/CT | 6q23.1 | SCF,
TGFb,
TNFa,
CSBG,
IL1,
BMPs,
FKHR,
Akt,
DIM,
WT1,
Egr1,
Lm, Pg Ye , MVA |
|||||||
NOV | human | IB/VWC/TSP1/CT | 8q24.1 |
Review of Wnt signaling by Polakis (Genes Dev. 2000), Peifer & Polakis (Science 2000), van de Wetering et al. (Cell 2002)
Microarray of APC by Lin et al. (Cancer
Res. 2001)
Microarray of RA & Wnt-1 by Tice et al. (J.
Biol. Chem. 2002)
Microarray & Proteomics analyses of
TGFbeta (by Verrecchia 2001)On-line review of
TGFb by Derynck & Zhang (Nature 2003), by Gorelik & Flavell (Nat Rev Immunol 2002)
TGFR family and TGF-associated
proteins
group | Protein | Species | KO | locus | 3D | upstream regulators | memo |
ActR-I, SKR1, ALK2 | human | 2q23-q24 | Ld, Subst.P | ||||
ActR-IB, SKR2, ALK4 | human | 1 | 12q13 | ||||
ActR-IC, ALK7, ACVR1C |
human |
2q24.2 |
induce
apoptosis |
||||
ActR-II | human | 1 | 2q22.2-q23.3 | ||||
ActR-IIB | human | 3p22-p21.3 | MTF1, HPV31, Ct, HHT | ||||
ALK1, SKR3 | human | 1 | 12q11-q14 | ALK1, | targets | ||
TGFR-1, SKR4, ALK5 | human | 1 | 9q33-q34 | 1 | Ma, insulin, cantharidin | targets | |
TGFR-2 | human | L | 3p22 | Sp1, FLI1, c-Myc, TNFa, CD3/28, WT1, IGFBP2, PPARa, TIMP1 | |||
BMPR-IA, SKR5, ALK3 | human | 1 |
10q22.3 | RA | |||
BMPR-IB, ALK6 | human | L | 4q23-q24 | cumulus expansion | |||
BMPR-II | human | 2q33 | ALK1 | ||||
AMHR | human | 1 | 12q13 | Hp | |||
TGFRbR III | human | 1 | 1p33-p32 | This is TGFR family but ZP | |||
CD105 | endoglin, ENG, CD105 | human | L | 9q33-q34.1 | HCV | TGFbR accessory | |
LTBP | LTBP1 | human | 2p12-q22 | assembly/secretion of TGFb1 | |||
LTBP2 | human | 14q24 | TNFa |
||||
LTBP3 | human | L | 11q12 | (EGF/TB)x2/EGFx14/TB/EGFx2/TB/EGFx2 | Stat4 | ||
LTBP4 | human | 19q13.1-q13.2 |
protein | Species | apoptosis | upstream regulators | KO | 3D | casp | memo | |
STAT1 | human, rat, mouse, Xl, zebrafish | inhibit/mediate | TRADD, Runx2 | TRAIL, Fas, IFNa, IFNg, IFNb, IL1b/IFNg, IFNk, CIITA, PMA, CD3&IL2, ZBP89, LPS, PGN, Mt, Pg, Sp, CpG, HCV, IGFBP3, ALK1, ischaemia, PIAS1, Cbl, Bcl6, ER, Ets1, A2aR, TIMP1, ribavirin | L | 1 | for IFNa,b,g, IL2,6,11,9,21,22,27,NNT |
|
STAT2 | human, mouse | IFNaR1 | IFNa/b,
UVA,
LTA,
Lm, TIMP1 |
1 | for IFNa,b, IL28A, 28B, 29 |
|||
STAT3 | human, mouse, rat, zebrafish |
|
ILRs, PKCd, NF-kB, caveolin-1, GRIM19, Hsp90 | IGF1,
IL6,
LPS,
Bm,
Ld,
Lm,
Mt,
Tg,
irrad,
Tyk2,
MEKK1,
TIMP1 |
L | 1 | IL2,6,7,9,10,11,21,22,27, IL28A, 28B,29,NNT, OSM,LIF, targets | |
STAT4 | human, mouse, zebrafish | IL1, IL2, AgII, PMA, PGN, Ld, Mt, Tg, phenytoin, UVA | L | IL12, 23,27, targets | ||||
STAT5 | human (A, B), mouse (A, B), rat (A, B), pig(A, B), bovine(A,B), sheep(A), chicken, Xl, trout, zebrafish |
|
CBP, NMI, HDAC1, SMRT | LPS,
PMA,CsA/FK506,
TNFa,
IL1b/TNFa,
IL5,
DEX,Cbl,
ER,
camptothecin,
methotrexate,
SCF;
adenosine |
L | IFNg, IL2,9,7,15,21,22,27, Epo, OSM,LIF | ||
STAT6 | human, mouse | NCoA-1, p100 | SCF, c-Myc | L | IL4,13 |
|||
Other | D.disc., C.e, ,D.m.. |
Protein | Species | binding partner | apoptosis | locus | memo |
Sara | human, mouse, Xl, Dm | Smad2 | 1p32.3 | Sara-N/FYVE/SBD/Sara-C | |
Endofin, ZFYVE16 | human, mouse | 5p15.2-q14.3 | KI-N/FYVE/Sara-C | ||
Kap-1 | C.elegans,AC004564.4(D.m.). | A-kinase RI | Kap-N/FYVE/Sara-C |
Microarray analysis of IFNa,
b and g targets
Interferon
Stimulated Gene Database
Protein | Species | KO | apoptosis | locus | structure | upstream regulators |
JAK1 | human, mouse,D.m. (HOPSCOTCH) | 1 | 1p32.3-p31.3 | ERMSH2/kinasex2 | FKHRL1, IFNa, FSH, Pa, Yp, Mt, TCPTP, BRCA1, methamphetamine | |
JAK2 | human, mouse | L |
inhibit/
mediate |
9p24 | ERM/SH2/kinasex2 | CD3&IL2,
ARNT2
|
JAK3/L-JAK | human, mouse | L | 19p13.1 | ERM/SH2/kinasex2 | Tprim, LPS, CSBG, Nef, TCPTP, PTH, androgen | |
Tyk2 | human, mouse | L | 19p13.2 | ERM/SH2/kinasex2 | PTP1B, PAF |
For interferon, interferon receptor, see ILs.
SOCS moved to E3.
name | Species | apoptosis | NF-kB | memo |
CGRP | human, mouse | enhance | inhibit |
CTGF family, ECM-associated
na,eas | Species | locus | KO | apoptosis | NF-kB | structure | regulator | memo |
CTGF, Fisp12, Hcs24 | human | 6q23.1 | 1 | induce/inhibit | IB/VWC/TSP1/CT | WT1, TGFb, TNFa, TGFb1, TGFb2, bFGF, EGF, VEGF(-), Lm, Thrombin, Src, PKC, Akt, PI3K, Flt1, KDR | ||
Nov | human | 8q24.1 | IB/VWC/TSP1/CT | |||||
CyR61, IGFBP10 | human | 1p22.3 | (inhibit) | IB/VWC/TSP1/CT | PDGF, serum, TGFb, PMA, v-src | angiogenesis | ||
WISP1 | human | 8q24.1-q24.3 | IB/VWC/TSP1/CT | Wnt1, CREB | ||||
WISP2 | human | 20q12-q13 | IB/VWC/TSP1/CT | estrogen, serum | ||||
WISP3 | human | 6q22-q23 | IB/VWC/TSP1/CT | Wnt1 |
family | name | species | KO |
structure | apoptosis | locus | regulator | memo |
Pleiotrophin | midkine/NEGF2 | human, mouse, X. laevis | Pro/R1/R2 |
|
11p11.2 | RARb2, androgen, TTF1, phenytoin | nucleolin | |
pleiotrophin/NEGF1/HBGF8 | human, mouse, zebrafish(1,2) | L |
Pro/R1/R2 |
|
||||
miple1 | fly (1) | Pro/R1/R2 | ||||||
miple2 | fly (2) | Pro/proDDPCD/R1/R2 | 3L; 61A1 |
family | name | species | memo |
NEP1 | NEP1 | Fusarium oxysporum, Pythium aphanidermatum | |
family | name | species | structure | apoptosis | NF-kB | locus | KO | TFs | regulator | memo |
PDGF | PDGFA | human | PDGF | inhibit/ induce | induce | 7p22 | WT1, Sp1, Egr1,Stat3, GCF2EGR1 | NRF2, KLF5, TGFb, IL1, RANKL, PMA, PKR, Erks, Nef, IL10/LPS, Hi, Ma, SCF, RA, ErbB4, D3 | targets | |
PDGFB/SIS | human | PDGF | 22q12.3-q13.1 | NF-kB,
Elk-1,
Smads,
Sp1 |
AII, RA, TGFb, TRH, TNFa, IL1, Pg, Ma, PKCzeta, hypoxia | p202, targets | ||||
PAP1, HASPP28, PDAP1 | human | PDGF | 7q22.1-7q31.33 | IGF1 | ||||||
VEGF | human | PDGF |
|
activate | 6p12 | Sp1 | NF-kB, IL-1, IL6, bFGF, HGF, ET-1, CD3, LPS, CSBG, Ct, Mt, Nc, HHV8, LMP1, TNFa, Fas, M-CSF, IFNa, Subst.P, IGF1, FSH, D3,Egr1, UV, irrad, HIF1, hypoxia, NO, Nef, sIL6R, Rac2, hypoxia, camptothecin, genistein, CD9 | targets | ||
VEGF B | human | PDGF |
|
11q13 | L | Sp1 | PDGF, PKC, PKCa, PKCzeta, PGE2, IL-1, GM-CSF, AII, IL-5PTH, hypoxia, Hp, E2F1, phenytoin, Blimp1 | |||
VRP, VEGF C | human | PDGF | 4q34.1-q34.3 | NF-kB, Stat4a, EWS/FLI-1, TNFa, IFNa, g, C5a, irrad, b-glucan, Ct, HHV8, HPV16, heregulin-beta1, TNFa, IL1b, p38, ribavirin | ||||||
FIGF/VEGF D | human | PDGF | Xp22.31 | c-fos | ||||||
PGF | human | PDGF | 14q24-q31 | MTF-1 | hypoxia, A2aR | |||||
SCDGF-B | human | CUB/PDGF | 11q22 | |||||||
PDGF C, SCDGF, fallotein | human | CUB/PDGF | 4q32 | c-Myb,
B-Myb,
LPS,
IL13 |
||||||
C11orf15 |
human |
induce |
11p15.3 |
|||||||
FLT3L | human |
|
19q13.3 | IL2, IL6, IL7, IL15, b-glucan, LMP1 | ||||||
MSP, HGFL, MST1 | human | 3p21 | 1 | RON | ||||||
Ephrin |
EFNA1, B61, EFL1, ECKLG, EPLG1,
LERK1 |
human | 1q21-q22 |
TNFa, PDX1 | ||||||
EFNA2, ELF-1, EPLG6, LERK6,
HEK7-L |
human |
19p13.3 |
||||||||
EFNA3, EFL2, EPLG3, LERK3 |
human |
1q21-q22 |
|
|||||||
EFNA4, EFL4, EPLG4, LERK4 |
human | 1q21-q22 |
||||||||
EFNA5, AF1, EFL5, RAGS, EPLG7, LERK7 | human | (-) |
5q21 |
1 | ||||||
EFNB1, EFL3, EPLG2, LERK2 | human | Xq12 |
||||||||
EFNB2, HTKL, EPLG5, Htk-L, LERK5 |
human | 13q33 |
1 |
|||||||
EFNB3, EFL6, EPLG8, LERK8 |
human | 17p13.1-p11.2 |
||||||||
SCF | SCF, KITLG, MGF, Steel | human, mouse, Xl |
|
12q22 | Sl(d) | IFNg,
IL1b,
IL6,
cAMP,
glucocorticoids,
b-catenin |
||||
EGF | epiregulin , EREG |
human |
4q21.2 |
EWS/FLI-1 |
||||||
NGF | BDNF | human |
|
11p13 | Brn3a/(-), VEGF, CREB, BMPs | |||||
NGFB | human | TNFa |
||||||||
neurotrophin-3, NTF3 | human | 12p13 | 1 | |||||||
neurotrophin 4/5, NTF5 | human | 19q13.3 | 1 | |||||||
ANP | ANP, atriopeptin, ANF, PND, NPPA | human |
|
|
1p36.2 | L | dHAND,
MEF2C,
endothelins, vasopressin, NO, adrenomedullin, PGs, hypoxia,
CRF, CGRP,
PAF, relaxin, cAMP, quabain, Tc |
corin | ||
BNP, NPPB | human | 1p36.2 | 1 | AIRE | ||||||
CNP, NPPC | human | 2q24-qter | D3 | |||||||
insulin | insulin, INS | human |
|
induce | 11p15.5 | Glc, PTHrP,
AIRE,
|
||||
INS2 |
mouse, rat |
AIRE | ||||||||
IGF2, somatomedin A | human |
11p15.5 | L |
AP1, AP2, C/EBPs, Egr1, HNF3b, p53, Sp1, WT1, GH, HBV-X, HCV, glucose, DEX, AIRE | ||||||
IGF1 | human |
|
induce | 12q22-q24.1 | L | AP1, Brn3a, C/EBPs, E2F, FOXA2, HNF1a, NRF2, p53, Sp1, STAT5s, STAT6, VDR, WT1, IL4, IL13, EGF, GH, PDGF, LPS, Mt, PTH, TGFb, serum, A2aR, IFNg, estrogen/ER, DEX, PGE2, PGA2, cAMP/PKA, ATM, | targets | |||
PDGFR | see kinases |
subgroup | name | species | structure | apoptosis | NF-kB | JNK/p38/AP1/Erks | locus | KO | regulators | expression |
memo |
Ligand | Angiotensinogen, AGT (AgI, AgII) | human | signal peptide/AgI/AgII/Serpin |
|
|
|
1q42-q43 | L | angiotensin, TNFa, NF-kB, TTF1, PRX2, RA, NPR1 | liver |
targets |
calcitonin, CALCA | human |
|
11p15.2-p15.1 | dorsal root ganglion | |||||||
CALCA, CT, KC, CGRP, CALC1, CGRP1, CGRP-I | human |
enhance |
inhibit |
(-)? | thyroid |
||||||
CGRP2, CALC2, CALCB | human | 11p15.2-p15.1 | dorsal root ganglion |
||||||||
corticotropin releasing hormone, CRH | human |
|
|
|
8q13 | L | placenta |
||||
Endothelin-1, EDN1, ET1 | human | endothelinx2 | inhibit/ induce |
|
|
6p24.1 | 1 | NF-kB, AP1, GATA2, HIF1, PPARa, CREB, p300/CBP, TNF, IL1, thrombin, TRH, Resistin, Bm, Cp, Ld, Lm, Mt, Tc, Tg, NO, leptin, shear stress, hypoxia, LPA, estrogen, D3, glucose,GATA2, PIASy | lung, cardiac |
||
Endothelin-2, EDN2 | human |
|
1p34 | LMP1 | |||||||
Endothelin-3, EDN3 | human | 20q13.2-q13.3 | 1 | Subst.P, LPS | |||||||
enkephalin, Penk | human |
8q23-q24 |
D3 |
||||||||
GIP | human | 17q21.3-q22 | small intestine |
||||||||
glucagon, GCG, GLP1, GLP2 | human |
|
|
2q36-q37 | L | panceratic islets |
|||||
gonadotropin-releasing hormone, LHRH, GNRH1, PIF | human |
|
|
8p21-p11.2 | hpg | IGF1 |
|||||
bombesin, gastrin-releasing polypeptide, GRP | human |
|
|
18q21 | Ret |
brain, lung |
|||||
oxytocin, OXT | human |
|
20p13 | L | hypothalamus |
social memory | |||||
vasopressin, neurophysin II, AVP | human |
|
|
20p13 | DI | c-Myc | hypothalamus |
||||
galanin, GAL | human |
|
11q13.1 | L | c-Myc | ||||||
gastrin, GAS | human |
|
|
|
17q21 | L | TNFa, IL1 | ||||
kininogen, KNG1 |
human | Cystatinx3/bradykinin |
|
|
3q27 | liver, kidney |
|||||
cholecystokinin, CCK | human |
|
|
|
3p22-p21.3 | bFGF, CREB, TNFa | brain |
||||
MSH, POMC | human | 2p23.3 | pituitary |
||||||||
neuropeptide Y, NPY | human |
|
7p15.1 | L | AP1,
AP2,
NF-kB,
Sp1,
Stat3/JAKs,
leptin,
NGF,
RA,
ER,
vaccinia
virus, CaMK |
||||||
pancreatic polypeptide, PP, PPY | human | 17q12-q21 | pacreatic islets |
||||||||
Peptide YY, PYY |
human |
17q21.1 |
1 |
||||||||
VIP | human | GLUCAx2 |
|
|
6q26-q27 | Smad3,
Smad4,
AP1,
STATs,
CNTF,
leptin,
TGFb, MVA |
|||||
PACAP, ADCYAP1 | human | GLUCAx2 |
|
18p11 | 1 | Brn3a | hypothalamus |
||||
parathyroid hormone, PTH | human |
|
11p15.3-p15.1 | 1 | Sp1, Sp3, VDR, D3, DEX | thyroid |
|||||
PTHrP, PTHLH | human |
|
12p12.1-p11.2 | 1 | Ets1, Ets2, Sp1, Smad3, TGFb, EGF, androgen, D3, E1A, PKCe | epithelial |
|||||
relaxin H1, RLN1 | human | IGF |
|
|
|
9p24.1 | 1 | ||||
relaxin H2, RLN2 | human | IGF | 9p24.1 | ||||||||
relaxin H3, RLN3 | human | IGF | 19p13.2 | ||||||||
secretin, SCT | human | GLUCA | 11p15.5 | placenta, B, epithelial |
|||||||
tachykinin, TAC1 (Substance K, P, neurokinin 1,2, L) | human |
|
induce(P) |
|
7q21-q22 | L | brain |
Subst.P targets | |||
thyrotropin-releasing hormone, TRH | human | 3q13.3-q21 | ErbB4 | hypothalamus |
|||||||
somatostatin, SST | human |
|
|
3q28 | panceatic isletes |
||||||
adrenomedullin, ADM | human |
|
|
11p15.4 | 1 | TNFa,
hypoxia,
D3 |
placenta, lung, adipocytes |
||||
adrenomedullin 2, ADM2 | human |
subgroup | name | species | structure | apoptosis | NF-kB | JNK/p38/AP1 | locus | KO | regulators | expression |
memo |
adrenergic alpha R |
ADRA1A, alpha 1 A | human | 7TM | 8p21-p11.2 | |||||||
ADRA1B, alpha 1 B | human | 7TM | 5q23-q32 | 1 | |||||||
ADRA1D, alpha 1 D | human | 7TM | 20p13 | ||||||||
ADRA2A, alpha 2 A | human | 7TM | 10q24-q26 | L | progesterone | ||||||
ADRA2B, alpha 2 B | human | 7TM | 2p13-q136 | 1 | |||||||
ADRA2C, alpha 2 C | human | 7TM | 4p16 | 1 | |||||||
angiotensin II R | AT2R1, AGTR1 | human | 7TM | 3q21-q25 | L | placenta, liver, adrenal, adipocyte | |||||
AT2R2, AGTR2 | human | 7TM |
|
Xq22-q23 | L | IRF1, | |||||
APJ, AGTRL1 | human | 7TM | 11q12 | 1 |
spinal cord |
||||||
ATR2L1, AGTRL2 | human | 7TM | 22q12.2 | ||||||||
PAF-R, PTAFR | human | 7TM |
|
induce | 1p35-p34.3 | GM-CSF | preB, APCs |
||||
adenosine R |
ADORA2A |
MVA | |||||||||
ADORA2B | human | 7TM | 17p12-p11.2 | VEGF,
IFNg |
|||||||
bradykinin R | BDKRB1 | human | 7TM | 14q32.1-q32.2 | FSH, IL1, TNFa, LPS | ||||||
BDKRB2 | human | 7TM | 14q32.1-q32.2 | L | p53, IGFBP2 | targets | |||||
bombesin R | bombesin-like receptor 3, BRS3 | human | 7TM | Xq26-q28 | 1 | ||||||
calcitonin R | calcitonin receptor, CALCR | human | Hrm/7TM | 7q21.3 | |||||||
CGRP R, CALCRL | human | Hrm/7TM | 2q32.2 | lung |
|||||||
cannabinoid R | CB1, CNR1 | human | 7TM | induce | 6q14-q15 | 1 | |||||
CB2, CNR2 | human | 7TM | 1p36.11 | ||||||||
endothelin R-like | EBI2 | human | 7TM | 13q32.2 | LPS, Ld, Lm,Mt, Tg, MDP, LTA, PMA, IL4, TGFb | APCs, B, T, NK |
|||||
ETRB, ETB, endothelin receptor B, EDNRB | human | 7TM |
|
induce |
|
13q22 | 1 | SCF,
PDTC,
relaxin,
AP1,
C/EBP,
TNFa |
|||
ETA, EDNRa, endothelin receptor a | human | 7TM |
|
|
|
4q31.21 | AgII | ||||
PAELR, GPR37 | human | 7TM | 7q31 | 1 |
brain, spinal cord |
||||||
lysophosphatidic acid R | GPR23 | human | 7TM | Xq13-q21.1 | cysteinyl leukotriene | ||||||
PAELR, GPR37 | human | 7TM | 7q31 | brain, spinal cord | |||||||
EDG2, LPA1, LPAR1, edg-2, vzg-1,
Gpcr26 |
human |
7TM | induce |
9q32 |
brain, spinal cord | ||||||
cholecystokinin R | CCK-A R, CCKAR | human | 7TM |
|
4p15.1-p15.2 | ||||||
gastrin R, CCKBR | human | 7TM | 11p15.4 | L | c-Myc | brain |
|||||
GRP R | GRPR | human | 7TM | Xp22.2-p22.13 | Rb2 | ||||||
dopamine R | D1, DRD1 | human | 7TM |
|
inhibit | 5q35.1 | 1 | brain |
|||
D2, DRD2 | human | 7TM |
|
induce | 11q23 | L | Ye | ||||
FY | FY, DARC, GPD | human | 7TM | 1q21-q2 | erythroid |
||||||
glucagon R | GCGR | human | Hrm/7TM | inhibit | 17q25 | 1 | liver, kidney |
||||
GLP1R | human | Hrm/7TM | inhibit | induce | 6p21 | ||||||
GLP2R | human | Hrm/7TM | inhibit | 17p13.3 | |||||||
glutamate R, metabolic | GRM7 | human | 7TM | 3p26.1-p25.2 | HCV | brain |
|||||
thrombin R | F2R | human | 7TM | induce | 5q13 | 1 | ALA |
||||
GPR7 | human | 7TM | 10q11.2-q21.1 | ||||||||
GPR8 | human | 7TM | 20q13.3 | ||||||||
GPR11, F2RL1, PAR2 | human | 7TM | 5q13 | ||||||||
GPR17 | human | 7TM | 2q21 | brain, spinal cord |
|||||||
GPR32 | human | 7TM | 19q13.3 | ||||||||
TG1019, OXER1, oxoeicosanoid R |
human | 7TM | 2p21 | liver, lung |
|||||||
GPR81 | human | 7TM | 12q | ||||||||
GPR20 | human | 7TM | 8q24.2-q24.3 | ||||||||
GPR31 | human | 7TM | 6q27 | ||||||||
GPR34 | human | 7TM | Xp11.4 | ||||||||
GPR35 | human | 7TM | 2q37.3 | ||||||||
GPR64, HE6 |
human |
7TM | Xp22.22 |
Brn3a,
androgen |
|||||||
GPR74 | human | 7TM | 4q21 | ||||||||
GPR87 | human | 7TM | 3q24 | epithelial |
|||||||
GPR89 |
human |
7TM |
1p36.13-q31.3 |
ALA |
|||||||
GPR92 | human | 7TM | 12p13 | ||||||||
H963 | human | 7TM | 3q25 | T, NK |
|||||||
GPR65, TDAG8 |
human |
7TM |
promote |
14q31-q32.1 | IL8 | ||||||
KiSS-1 receptor |
GPR54, AXOR12; HOT7T175 |
human |
7TM | 19p13.3 |
(puberty) |
targets | |||||
sphingosylphosphorylcholine R | OGR1, GPR68 | human | 7TM | 14q31 | SPC R | ||||||
GPR4 | human | 7TM | 10q11.2-q21.1 | c-Myc | SPC & LPC R | ||||||
tachykinin
R |
TACR1, NK1R |
human |
7TM |
2p12 |
1 |
TNFa |
|||||
TACR2, NK2R, NKNAR |
human |
7TM |
10q11-q21 |
||||||||
TACR3, NK3R | human |
7TM | 4q25 |
||||||||
histamine R |
H1, HRH1 | human | 7TM | induce | 3p25 | L | IL4, IL12 | ||||
H2, HRH2 | human | 7TM | 3p25 | L | |||||||
H3, HRH3 | human | 7TM |
|
20q13.33 | L | androgen |
|||||
H4, HRH4 | human | 7TM | 18q11.2 | ||||||||
melanocortin R | MC2R, ACTH R, adrenocorticotropic hormone R | human | 7TM | 18p11.2 | pituitary |
||||||
MC5R | human | 7TM | 18p11.2 | 1 | |||||||
MC1R, MSH R | human | 7TM | 16q24.3 | 1 | |||||||
MC3R | human | 7TM | 20q13.2-q13.3 | 1 | |||||||
MC4R, MCR R | human | 7TM | 18q22 | 1 | |||||||
muscarinic acetylcholine R | CHRM1 | human | 7TM | 11q13 | 1 | ||||||
CHRM2 | human | 7TM | 7`q31-q35 | ||||||||
CHRM3 | human | 7TM | 1q41-q44 | 1 | |||||||
CHRM4 | human | 7TM | 11p12-p11.2 | 1 | |||||||
CHRM5 | human | 7TM | 15q26 | 1 | |||||||
nicotinic acid R | HM74, PUMA-G, GPR109A |
human | 7TM | 12q24.31 | 1 | LPS,CpG, dsRNA, OX-CA, TNFa, IFNg | myeloid |
||||
chemokine-like receptor 1 |
CMKLR1, DEZ, ChemR23 |
human |
7TM | 12q24.1 |
ARNT2 | ||||||
adenosine R | adenosine A1 receptor, ADORA1, RDC7 | human | 7TM | 1q32.1 | L | RANKL, IFNa | brain, spinal cord |
||||
ADORA2A, A2a R | human | 7TM | 22q11.23 | L | targets | ||||||
ADORA2B, A2b | human | 7TM | 17p12-p11.2 | sm. muscle, cardiac, epithelial |
|||||||
ADORA3, A3 | human | 7TM | 1p21-p13 | 1 | |||||||
P2Y (&P2X) | P2Y1, P2RY1 | human | 7TM |
|
|
3q25 | L | ATP, ADP | |||
P2RY12 | human | 7TM | 3q24-q25 | brain, spinal crd |
ADP | ||||||
P2X1, P2RX1 | human | P2X |
|
17p13.3 | 1 | DEX | APCs |
||||
P2X3 | human | P2X | 11q12 | L | |||||||
P2X7, P2Z, P2RX7 | human | P2X |
|
|
|
12q24 | L | EMP1,2,3, PMP22 | |||
P2RX5, P2X5R | human | P2X | 17p13.3 | AdV | B |
||||||
P2Y2, P2RY2 | human | 7TM |
|
11q13.5 | 1 | TCR,
estrogen |
epithlial APCs |
ATP, targets |
|||
P2Y6 | human | 7TM | 11q13.5 | HIV Vpr | |||||||
P2RY4 | human | 7TM | Xq13 | UTP, UDP | |||||||
FKSG79 | human | 7TM | Xq13.2 | ||||||||
P2RY5 | human | 7TM | 13q14 | APCs, T, NK |
|||||||
P2RY10, P2Y10 | human | 7TM | Xq21.1 | PU.1,
Spi-B,
MIP3 |
B |
||||||
P2RY11 | human | 7TM | 19p13.2 | ||||||||
P2Y14, GPR105 | human | 7TM | 3q21-q25 | uterus, ovary |
UDP-Glc, targets |
subgroup | name | species | structure | apoptosis | NF-kB | JNK/p38/AP1 | locus | KO | regulators | expression |
memo |
oxytocin R | oxytocin receptor, OXTR | human | 7TM | 3p25 | VEGF, LPS | ||||||
corticotropin releasing hormone R | CRHR1 | human | Hrm/7TM | 17q12-q22 | 1 | Targets | |||||
CRFR2 | human | Hrm/7TM | 7p15.1 | L | |||||||
gonadotropin-releasing hormone R | GNRHR | human | 7TM | 4q21.2 | pituitary |
||||||
GNRHR2 | human | 7TM | 1q12 | ||||||||
growth hormone releasing hormone R | GHRHR | human | Hrm/7TM | 7p14 | pituitary |
||||||
somatostatin R | Somatostatin receptor 1, SSTR1 | human | 7TM | 14q13 | |||||||
SSTR2 | human | 7TM | 17q24 | CREB | |||||||
SS4R, SSTR4 | human | 7TM | 20p11.2 | P2Y2 | |||||||
SSTR5 | human | 7TM | induce | 16p13.3 | erythroid |
||||||
SSTR2 | human | 7TM |
|
17q24 | 1 | ||||||
SSTR3 | human | 7TM |
|
22q13.1 | |||||||
MCHR1, SLC1, GPR24 | human | 7TM | 22q13.2 | 1 | MCH | ||||||
galanin R | galanin receptor 1, GALR1 | human | 7TM | 18q23 | L | Subst.P, NF-kB, LPS, Ec | |||||
galanin receptor 2, GALR2 | human | 7TM |
|
17q25.3 | |||||||
galanin receptor 3, GALR3 | human | 7TM | 22q13.1 | ||||||||
GIPR | human | Hrm/7TM | 19q13.3 | 1 | |||||||
leukotriene R | leukotriene B4 R, LTB4 R, P2RY7, BLTR, GPR16, BLT1 |
human | 7TM | 14q11.2-q12 | L | Sp1, IL13, DEX | APCs, T, NK |
T cell recruitment | |||
LTB4 R2, BLTR2 | human | 7TM | 14q11.2-q12 | ||||||||
LTC4 R1, CYSLTR1 | human | 7TM | induce | induce | Xq13.2-21.1 | 1 | |||||
LTC4 R2, CYSLTR2 | human | 7TM | 13q14.12-q21.1 | ||||||||
GABA B R | GABBR1 | human | 7TM | 6p21.31 | 1 | brain |
|||||
metabotropic glutamate R | GRM1, mGluR1 | human | 7TM | 6q24 | L | brain |
|||||
GRM2, mGluR2 | human | 7TM | 3p21.31 | 1 | heart |
||||||
GRM3, mGluR3 | human | 7TM | 7q21.1-q21.2 | brain |
|||||||
GRM4, mGluR4 | human | 7TM | 6p21.3 | 1 | cerebellum |
||||||
GRM5, mGluR5 | human | 7TM | 11q14.1 | 1 | brain |
||||||
GRM6, mGluR6 | human | 7TM | 5q35 | 1 | |||||||
GRM7 | human | 7TM | 3p26.1-p25.1 | brain |
|||||||
GRM8 | human | 7TM | 7q31.3-q32.1 | ||||||||
neurokinin R | TACR1, NK1R (substance P receptor) | human | 7TM |
|
|
2p12 | 1 | NF-kB, IL1b, IL4, IL18, IL12, SCF | |||
TACR2, NK2R | human | 7TM |
|
|
10q11-q21 | ||||||
TACR3, NK3R | human | 7TM |
|
|
4q25 | ||||||
neuropeptide Y R | Y1, NPYR, NPY1R | human | 7TM | 4q31.3-q32 | L | Brn3a, FSH | fetal brain |
||||
Y2, NPY2R | human | 7TM | 4q31 | L | |||||||
Y5, NPY5R | human | 7TM | 4q31-q32 | ||||||||
Y2B, Y6, PP2, NPY6R | human | 7TM | 5q31 | ||||||||
neurotenin receptor 2 | NTSR2 | human | 7TM | 2p25.1 | CLOCK | hypothalamus |
|||||
Serotonin R | HTR1A | human | 7TM |
|
5q11.2-q13 | 1 | liver |
||||
HTR2B | human | Hrm/7TM |
|
induce |
2q36.3-q37.1 | uterus |
|||||
PACAP R | PACAP R (type I), ADCYAP1R1 | human | 7TM |
|
7p14 | p53, Zac | |||||
opioid | opioid receptor kappa 1, OPRK1 | human | 7TM | 8q11.2 | 1 | ||||||
OPRL1, LC132 R, nociceptin R, NOCIR | human | 7TM | 20q13.33 | nociceptin | |||||||
OPRD1, delta 1 | human | 7TM | 1p36.1-p34.3 | ||||||||
OPRM1, mu 1 | human | 7TM | 6q24-q25 | ||||||||
pancreatic polypeptide R | Y4, PP1, NPY4R, PPYR1 | human | 7TM | 10q11.2-q21.2 | 1 | D3 | |||||
prostaglandin R | EP1, prostaglandin E receptor 1, PTGER1 | human | 7TM | 19p13.1 | L | ||||||
EP2, prostaglandin E receptor 2, PTGER2 | human | 7TM | 14q22 | L | ribavirin, c-Myc | NK |
|||||
EP3, prostaglandin E receptor 3 , PTGER3 | human | 7TM | 1p31.2 | L | PDX1, AIRE | ||||||
EP4, prostaglandin E receptor 4, PTGER4 | human | 7TM | 5p13.1 | L | HSV1 |
NK, myeloid |
targets |
||||
FP, PTGFR | human | 7TM | 1p31.1 | 1 | calcineurin | uterus |
|||||
formyl peptide R | FPR1 | human | 7TM | 19q13.4 | LPS,
hsp65,
IL8 |
myeloid |
|||||
lipotoxin A4 R |
HM63, FPRH1, LXA4R, FPRL1 | human | 7TM | 19q13.3-q13.4 | neutrophil |
||||||
FPRL2, FPRH2 | human | 7TM | 19q13.3-q13.4 | LPS, IL4 | |||||||
melatonin R | melatonin receptor 1A, MTNR1A | human | 7TM |
|
4q35.1 | VEGF, GnRH, VDR, IGFBP2 | |||||
RDC1 | RDC1, GPR159 |
human | 7TM | 2q37.3 | PRX2 |
HIV coR | |||||
vasopressin R | AVPR1A | human | 7TM |
|
12q14-q15 | ||||||
AVPR1B, AVPR3 | human | 7TM | 1q32 | ||||||||
AVPR2, V2R, ADHR | human | 7TM | induce | Xq28 | |||||||
adrenomedullin R | ADMR | human | 7TM | 12q13.13 | |||||||
TRH R | TRHR | human | 7TM | 8q23 | CREB | hemato. |
|||||
orphan | TPRA40 | human | 7TM | 3q21.2 | Ye | ||||||
RAIG2, GPRC5B |
7TM | 16p12 |
RA,
TNFa |
brain |
|||||||
RAMP | RAMP3 | human | RAMP | 7p13-p12 | PDGF | bind to ADMR |
subgroup | name | species | structure | apoptosis | NF-kB | JNK/p38/AP1 | locus | KO | regulators | expression |
memo |
brain-specific angiogenesis inhibitor | BAI1 | human | TSP1s/GPS/7TM | 8q24 | |||||||
BAI2 | human | TSP1s/GPS/7TM | 1p35 | brain |
|||||||
BAI3 | human | TSP1s/GPS/7TM | 6q12 | brain |
|||||||
other GPS | GPR56 | human | ?/GPS/7TM | 16q13 | HCV | NK |
|||||
GPR126, VIGR |
human |
CUB/GPS/7TM |
6q24.1 |
TNFa | placenta |
||||||
GPR133 | human | GPS/7TM | 12q24.33 | ||||||||
TSH R | TSHR | human | LRRs/7TM | 14q31 | 1 | thyroid |
|||||
LGR5, GPR49 |
human |
LRRs/7TM |
12q22-q23 |
HNF4a | orfactory bulb |
||||||
relaxin R | LGR7 | human | LRRs/7TM | 4q32 | 1 | LPS |
|||||
CD97 | CD97 | human | EGFx5/GPS/7TM | 19p13.2-p13.12 | Yp,
BMP2,
TGFb |
NK, leukocytes | CD55 receptor | ||||
EMR1 | human | EGFx6/GPS/7TM | 19p13.3 | G-CSF | NK, leukocytes | ||||||
EMR2 | human | EGFx6/GPS/7TM | 19p13.1 | NK, leukocytes | |||||||
Other Hrm | parathyroid hormone (PTH)/ PTHrP R, PTHR1 | human | HRM/7TM | mediate | 3p22-p21.1 | 1 | Sp1, MAZ, PTH, D3 | kidney |
|||
PTHR2 | human | HRM/7TM | 2q33 | ||||||||
secretin R | human | HRM/7TM | 2q14.1 | ||||||||
VIP R, VIPR1, RDC1, PACAP R | human | HRM/7TM | 3p22 | progesterone | |||||||
VIPR2 | human | HRM/7TM | 7q36.3 | LPS | |||||||
flamingo | CELSR1, FMI2 | human, mouse | CAx9/EGFx3/LaminG/EGF/LaminG/EGFx3/HRM/GPS/7TM | 22q13.3 | fmi | ||||||
CELSR2, EGFL2, MEGF3 | human, mouse | 1p21 | brain |
||||||||
CELSR3, FMI1, MEGF2 | human, mouse, rat | Cadx9/EGFx3/LamineG/EGF/LaminG/EGFx3/HRM/GPS/7TM | 3p24.1-p21.2 | brain |
|||||||
MASS1 | MASS1, VLGR1 | human | Calx-betax22/GPS/7TM | 5q13 | m | ||||||
calcium-sensing R | CASR, PCAR1 | human | ANFR/7TM | 3q21-q24 | 1 | ||||||
renin | renin, REN | human | Asp protease | 1q32 | CREB, Pit1, AP1, NF-Y, Sp1, Sp3, Ear2, T3, D3, TNFa, AgII, cAMP, PKA, Ref1, P2Y11 | ||||||
ACE | ACE1, ACE, DCP1, kininase II, CD143 | human | ACE or M2x2/TM | inhibit? | 17q23 | L | c-Myc,
pleiotrophin,
Ma |
cleave angiotensin I, bradykinin | |||
ACE2 | human | ACE | Xp22 | ||||||||
RAMP |
RAMP1 |
human |
RAMP |
D3 |
|||||||
RAMP3 |
human |
RAMP |
|||||||||
See lists of chemokine
receptor for chemokine receptors, C3aR & C5R1, lipid
metabolism, prostaglandin, leukotriene synthesis |
Endothelin by Kedzierski & Yanagisawa (Annu Rev Pharmacol Toxicol 2001)GPCRDB: Information system for G protein-coupled receptors (GPCRs)
Protein | species | apoptosis | NF-kB | KO | locus | structure | upstream regulators | 3D | casp | memo | ||
Notch | Notch1, TAN1 | human, mouse, rat, Xl, zebrafish, sea urchin |
|
inhibit | L | 9q34.3 | Delta1 | EGFx36/NLx2/TM/Ank6 | Mad1, Notch, LMP1, cortisol, HHV8 | targets | ||
Notch2 | human, mouse, rat, chicken, fugu, fly |
|
L | 1p13-p11 | Delta1, Jagged1, Jagged2 | EGFx36/NLx2/TM/Ank6 | cortisol, RA | |||||
Notch3 | human, mouse, rat |
|
activate | 1 | 19p13.2-p13.1 | EGFx34//NLx3/TM/Ank6 | BMP2,
Egr1,
Cdx2,
TNFa,
Pg |
|||||
Notch4 | human, mouse, |
|
6p21.3 | UVB, c-Myc | ||||||||
Delta-1 | Delta1, DLL1 | human, mouse, rat, zebrafish | L | 6q27 | EGFx10/TM | ARNT2 | ||||||
DLK1, PREF1, FA1, pG2 | human, mouse, rat, bovine | 14q32 | ||||||||||
DLL3 | human, mouse | 19q13 | ||||||||||
DLL4 | human, mouse | 15q14 | ||||||||||
Jagged-1, JAG1 | human | 20p12 | EGFx18/VWC/TM | TNFa, IL1, IL13, LPS,MDP, AgII, PTH, IGFBP2 | ||||||||
Jagged-2, JAG2 | human | 14q32 | LMP1, Stat4 | |||||||||
Deltex |
Deltex 1 , DTX1 |
human |
12q24.21 |
Grb2 |
Cdx2, Notch | |||||||
Deltex 2, DTX2 |
human | 7q11.23 |
AIRE | |||||||||
Deltex 3, DTX3 |
human | 12q13.2 |
||||||||||
Deltex 4, DTX4 |
human | 11q12.2 |
||||||||||
CBF1 | CBF1, RBPJK, IGKJRB1,LAG2, RBPSUH | human | 9p13-p12 | Notch | TIG | |||||||
RBP-L, RBPSUHL | human | 20q12-q13.1 | ||||||||||
nicastrin | nicastrin | human, mouse, Dm, Ce | 1q22-q23 | PSs, BACE1 | aminopeptidase/TM | |||||||
presenilin | see other apoptosis regulators | |||||||||||
BACE | human | L | 11q23.2-q23.3 | Hp | ||||||||
HEY |
for
hairy enhancer-of-split, see TFs |
Review by
Darnell (Science 1997 )
Other factors
EGF
family | name | species | apoptosis | locus | upstream regulators | memo |
EGF | amphiregulin | human | 4q13-q21 | PTH, Hp |
family | name | species | apoptosis | locus | upstream regulators | memo |
FGF | see ILs | anti-BMP4 function | ||||
SHIP | SHIP | human | induce | |||
SPARC | human | 5q31.3-q32 | EDA |
family | name | species | apoptosis | upstream regulators | memo |
FSH | FSH | human | inhibit | targets | |
FSHR | FSHR | human | USFs, SF1, PKA |
GDNF targets
Reelin/Disabled
Group | Protein | Species | KO | apoptosis | locus | structure | bound | upstream regulators |
Disabled | Disabled-1, DAB1 | human | 1 | 1p32-p31 | PTB | Pcdh18 | ||
Disabled-2, DAB2 | human | 5p13 | PTB | ICSBP,
TGFb |
||||
Reelin | Reelin, RELN | human | 1 | 7q22 | Reelin/[BNR/EGF/BNR]x7 | BDNF, AIRE | ||
ApoE R | ApoE R2 , LRP8 | human | 1p34 | LDLx7/EGFx2/LYx6/EGF/TM/(pY) | Disabled |
Group | Protein | Species | KO | apoptosis | locus | structure | bound | upstream regulators |
LECT2 |
LECT2, leukocyte cell-derived chemotaxin 2,
chondromodulin-II, mim-1 |
human,
mouse,
rat,
bovine,
chicken,
fugu,
Ce, |
1 | 5q31.1-q32 | LECT2 |
Review of JAK by
Mathey-Prevot & Perrimon
Review
[General]
Dimerization as a regulatory mechanism by Klemm et al. (Annu. Rev. Immunol. 1998)
Lafmid BA
pBluescript II SK(-), Stratagene original homepage of Bluescript series
pBK-CMV
pCMV-SPORT
pCMVSPORT6
pECFP-C1
pEYFP-C1 (strong F)
pET30a(+) (Map)
pME18S-FL3
pOT2 (Chloramphenicol 12.5 mg/l)
pOTB7
pSPORT1
pT7T3D-PAC
Other from IMAGE
pMSCV-puro
pMSV-neo
pMSV-hygro
Other Clontech (BD) vectors
Cytokines Online Pathfinder Encyclopaedia
Cell Signaling Networks Database
The Promoter Database of Saccharomyces cerevisiae
List of E. coli Transcription Factors
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