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RESEARCH ARTICLES

1, Zhang X., Zheng N and Rosania GR (2007)  Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic mnobasic amines. Journal of Computer Aided Molecular Design (submitted).

2. Trapp, S; Rosania GR, Horobin R. and Kornhuber J.. (2007) Quantitative modeling of selective lysosomal. targeting by passive diffusion of xenobiotic compounds: model development and simulations for single cells. Journal of Medicinal Chemistry (submitted).

3. Park, J., Rosania, G., Shedden, K., Nguyen, M., Lyu, N., Saitou, K.,(2007)  "Automated Extraction of Chemical Structure Information from Digital Raster Images," Cheminformatics, submitted.

4. Rosania, GR; Crippen G, States D, Woolf P and Shedden K (2007) A Cheminformatic toolkit for mining biomedical knowledge.  Pharmaceutical  Research Oct;24(10):1791-802. [PubMed]

5. Chen, VY, Posada, MM, Zhao, L, and Rosania GR (2007).  Rapid doxorubicin efflux from the nucleus of drug resistant cancer cells following extracellular drug clearance. Pharmaceutical Research Nov;24(11):2156-67.[PubMed]

6. Maria M Posada, Kerby Shedden, Young Tae Chang, Qian Li and Gus R. Rosania  (2007). Prospecting for live cell bioimaging probes with cheminformatic assisted image arrays (CAIA).  Proceedings of the 4th IEEE International Symposium on Biomedical Imaging: from Nano to Macro.  Pp. 1108-1111. [article]

7. Xinyuan Zhang, Kerby Shedden, Gus Rosania. (2006). A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration.  Molecular Pharmaceutics; 3(6) pp 704 - 716. [PubMed]

8. Zhang X. and Rosania GR.  (2006) A virtual cell-based simulator for pharmaceutical project management, risk assessment and decision making.  Proceedings of the 4th International Conference on Computer Science and its Applications, pp. 58-65. US Education Service, San Diego, CA.

9. Vivien Y. Chen, Maria M. Posada, Levi L. Blazer, Tong Zhao, and Gus R. Rosania (2006)  The role of the Vps4a-exosome pathway in the intrinsic egress route of DNA-binding anticancer drug.   Pharmaceutical  Research. 23(8): 1687-1695. [PubMed]

10. Vivien Y. Chen and Gus R. Rosania (2006) The great multidrug resistance paradox. ACS Chem. & Biol. 1(5):271-273 click here for web edition.

11.. Qian Li, Yunkyung Kim, Joshua Namm, Amita Kulkarni, Gus R. Rosania, Young-Hoon Ahn, Young-Tae Chang (2006) RNA-selective, Live Cell Imaging Probes for Studying Nuclear Structure and Function.  Chemistry and Biology Jun;13(6):615-23. [PubMed]   Previewed in “Styryl molecules light-up RNAs, Dirks, R. W.; Tanke, H. J. Chem. Biol. 2006, 13, 560-561.”; Highlighted in Styryl dyes image RNA in living cells, C&En News, 2006 (July 3), 84 (27), 30 ; RNA dyes for life, Rothman, S. The Scientist, 2006, 20, 67; Illuminating cellular RNA, Sheppard, T. L. Nat. Chem. Biol. 2006, 2, 405 ; Live and let dye, Biotechniques 2006, 41, 231

12.. Chen, V.Y., Khersonsky, S.M., Shedden, K., Chang, Y.T., and Rosania, G.R. (2004) System Dynamics of Subcellular Transport. Molecular Pharmaceutics.  1(6): 414-425.[PubMed]

13. Shedden K, Rosania GR. (2004)  Exploratory chemoinformatic analysis of cell type selective anticancer drug targeting.  Molecular Pharmaceutics.  1(4): 267-280. [PubMed]

14. Kim S., Rosania, GR, and Chang YT. (2004) Dediifferentiation? What's next?  Molecular Interventions. Apr;4(2):83-5. [PubMed]

15. Rosania GR (2004) Mitochondria give cells a tan.  Chem Biol. 12(4) 412-413. [PubMed]

16. Shedden K, Brumer J, Chang YT and Rosania GR (2003) Chemoinformatic analysis of a supertargeted library of styryl molecules.  J. Chem. Info and Comp. Sci.  43(6):2068-80. [PubMed]

17. Shedden K, Xie XT, Chandaroy P, Chang YT, Rosania GR. (2003) Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles. Cancer Research. 2003 Aug 1;63(15):4331-7 [PubMed]

18. Lee, J. W.; Jung, M.; Rosania, G. R.; Chang, Y. T. (2003) Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell based screening,  ChemComm 2003, 1852-1853 [PubMed]

19. Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL, 2003  Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.  Biochem Biophys Res Commun. Aug 1;307(3):696-703 [PubMed]

20. Rosania G. R. (2003)  Supertargeted Chemistry: Identifying Relationships Between Molecular Structures and Their Sub-Cellular Distribution. Curr. Top. Med. Chem. 3(6):659-685. [PubMed] 

21.  Shedden K, Drach JC, Towsend L, and Rosania GR (2003)  A Rational Approach to Personalized Anticancer Therapy: Chemoinformatic analysis reveals mechanistic gene-drug associations.  Pharmaceutical  Research 20(6):843-847[PubMed]

22. Rosania, GR, Ding, L, Yoon, H-S, and Chang, YT (2003) Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold. J Am Chem Soc. Feb 5;125(5):1130-1 [PubMed]

23. Moon HS, Jacobson EM, Khersonsky SM, Luzung MR, Walsh DP, Xiong W, Lee JW, Parikh PB, Lam JC, Kang TW, Rosania GR, Schier AF, Chang YT. (2002) A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.  J Am Chem Soc. Oct 2;124(39):11608-9. [PubMed]

24. Perez,OD, Chang, YT, Rosania,G, Sutherlin,D and Schultz, PG (2002) Inhibition and Reversal of Myogenic Differentiation by Purine-Based Microtubule Assembly Inhibitors. Chemistry and Biology  9(4): 475-483 [PubMed].  **Cover article

25. Chang, Y.T., Wignall, S.M., Rosania, G.R., Gray, N.S., Hanson, S.R., Su, A.I., Merlie, J Jr., Moon, H.S. Sangankar, S.B., Perez, O., Heald, R., and Schultz, P.G. (2001) Synthesis and Biological Evaluation of Myoseverin Derivatives: Microtubule Assembly Inhibitors.   J Med Chem  Dec   20;44(26):4497-4500. [PubMed]

26. Chang, Y.T., Rosania, G.R., and Chung, S.K. (2001) Inositol phospholipid pathway inhibitors and regulators.  Expert Opin. Therap. Patents. 11(1):45-58.

27. Rosania, GR and Chang YT (2000) Targeting hyperproliferative disorders with cyclin dependent kinase inhibitors.  Expert Opin. Therap. Patents   10:215-230.

28. Rosania GR, Chang YT, Perez O, Sutherlin DS, Dong H, Lockhart DJ, and Schultz PG. (2000)  Myoseverin: a microtubule binding molecule with novel cellular effects.  Nature Biotechnol.  18: 304-308 [PubMed].  **Cover article, plus commentaries.