NIH Post-doctoral Training Grant in Cardiovascular Disease
The purpose of this NIH sponsored training grant is to provide an intensive research training experience in basic or translational cardiovascular research. The program is designed for postdoctoral MD's or PhD's in preparation for independent investigative careers related to cardiovascular disease. Cardiovascular fellowship applicants will find this an especially valuable opportunity to focus on an area of research interest under the guidance of established mentors in the field. A diverse array of training opportunities are available ranging from basic mechanisms of vascular disease to applied translational research. The University of Michigan Cardiovascular Center, Department of Internal Medicine, comprises the central foundation of this grant, although multiple links to other Divisions and Departments within the University of Michigan Medical School have been established to facilitate collaborations and novel pursuits in this rapidly expanding field. In addition to a multitude of basic research opportunities available through this grant, a translational scientific program has been developed to meet the needs of trainees interested in clinical investigation. This translational research program also provides an opportunity to complete a Masters of Science program in research design and statistical analysis within the University of Michigan School of Public Health.
A core curriculum of didactic seminars designed specifically for trainees, interdisciplinary symposia and journal clubs have been established. Funding through this grant is available for 2-3 years.
Current research opportunities include:
Signaling pathways in ischemia-reperfusion injury
CD39 ectonucleotidase in coagulation and inflammation
PAI-1 in atherosclerosis and thrombosis
Leptin in thrombosis and atherosclerosis
Genetic modifiers of obesity
Glycophingolipids in vascular disease
Molecular mechanisms of cardiomyocyte differentiation from embryonic precursors
Role of troponin I in the adult cardiac myocyte contractile response to PKC
Molecular mechanisms regulating smooth muscle proliferation
Role of cardiac renin-angiotension system in myocyte hypertrophy
Novel genetic modifiers of thrombosis
Structure and function of voltage-gated sodium channels
Mechanisms involved in obesity-induced hypertension
Regulation of protein folding
Protein-protein interaction domains in cell signaling
Basic mechanisms of hypertrophic cardiomyopathy
G-protein mediated pathways in cardiovascular disease
The kallikrein/kinin system in vascular disease
Mechanisms involved in pulmonary fibrosis
Sympathetic nervous system and adrenergic responsiveness in aging
Inflammation in venous thrombosis
Genetic modifiers of hypertension
Matrix metalloproteinases in vascular disease
Tools for measuring cardiovascular complications of diabetes
Cardiovascular outcomes
Current list of participating investigators:
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Bernstein, Steven, MD, MPH Associate Professor of Internal Medicine Associate Research Scientist of Health Management & Policy |
Duan, Cunming, PhD Associate Professor of Molecular, Cellular, and Developmental Biology |
Eagle, Kim A., MD, FACC Albion Walter Hewlett Professor, Internal Medicine Clinical Director of Cardiovascular Center |
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Associate Professor of Internal Medicine Division of Cardiovascular Medicine Director & Principal Investigator of Cardiovascular Research Training Grant |
Ginsburg, David, MD James V. Neel Distinguished University Professor Professor of Internal Medicine and Human Genetics Investigator of Howard Hughes Medical Institute |
Gordon, David, MD Associate Dean for Diversity & Career Development Professor of Pathology |
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Grekin, Roger J., MD Professor of Internal Medicine, Division of Endocrinology VA Associate Chief of Staff, Research & Development |
Hayward, Rodney A., MD Director, VA Center for Practice Mgmt. & Outcome Research Professor of Internal Medicine & Public Health Mgmt. & Policy Director, Measurement Core, MI Diabetes Research & Training Center |
Isom, Lori L., PhD Associate Professor of Pharmacology |
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Katz, Steven J., MD, MPH Associate Professor of Internal Medicine and Dept. of Health Mgmt. & Policy, School of Public Health Director of Health Services Research, Comprehensive Cancer Center |
Kaufman, Randal J., PhD Professor of Internal Medicine & Biological Chemistry Research Investigator, Howard Hughes Medical Institute |
Lucchesi, Benedict R., MD, PhD, FAHA Professor of Pharmacology |
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Margolis, Benjamin, MD Professor of Internal Medicine and Biological Chemistry Associate Investigator of Howard Hughes Medical Institute |
Metzger, Joseph, PhD Professor of Internal Medicine & Physiology Director, Center for Integrative Genomics Research Professor of Gerontology |
Mortensen, Richard, MD. PhD Associate Professor of Molecular & Integrative Physiology Associate Professor of Pharmacology, Metabolism, Endocrinology, & Diabetes |
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Neubig, Richard, MD, PhD Professor of Internal Medicine & Pharmacology |
Omenn, Gilbert, MD, PhD Professor of Internal Medicine, Human Genetics & Public Health |
Pinsky, David J., MD J. Griswold Ruth M.D.& Mary Hopkins Ruth Professor of Internal Medicine Chief of Cardiovascular Medicine Professor, Molecular & Integrative Physiology Scientific Director, Cardiovascular Center |
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Schmaier, Alvin H. MD Professor of Internal Medicine & Pathology Division of Hematology Director, Coagulation Laboratory |
Shayman, James A., MD Professor of Internal Medicine & Pharmacology Division of Nephrology Associate Chair, Research Program
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Simon, Richard H., MD Professor of Internal Medicine Division of Pulmonary and Critical Care Medicine |
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Supiano, Mark A., MD Professor of Internal Medicine Division of Geriatrics Director, VA Ann Arbor Geriatric Research, Education Clinic Center Research Professor of Institute of Gerontology |
Upchurch, Gilbert, MD Associate Professor of Vascular Surgery |
Wakefield, Thomas, MD Professor of Vascular Medicine Chief, Vascular Surgery Department
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Weder, Alan B., MD Professor of Internal Medicine Co-Director, Vascular Medicine, Division of Cardiology |
Weiss, Stephen J., MD Chief, Molecular Medicine & Genetics Upjohn Professor of Oncology |
Westfall, Margaret V., PhD Assistant Professor of Surgery & Physiology |
Current Research Fellows:
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Chan, Paul, M.D School of Public Health, Cardiology |
Herron, Todd J., Ph.D. Molecular & Integrative Physiology |
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Huang, Xinyan, M.D. Pharmacology |
Koenig, Gerald, M.D., Ph.D Molecular Medicine & Genetics |
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Nieman, Marvin, Ph.D. Hematology/Oncology |
Ohman, Miina, M.D., Ph.D. Cardiology |
For questions about this NIH Training Grant Program, contact John Burnett, Internal Medicine, Division of Cardiology, Cardiovascular Training Grant Coordinator. dual@umich.edu